Cochrane · systematic review · CD001969
Early administration of inhaled corticosteroids for preventing chronic lung disease in very low birth weight preterm neonates
Shah, VS, Ohlsson, A, Halliday, HL, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
3
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 3 · 100%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Early inhaled steroids (< 2 weeks) compared to placebo (among all randomised) for preventing chronic lung disease in very low birth weight preterm neonates
Population: very low birth weight preterm neonates
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
CLD at 36 weeks' PMA oxygen dependency at 36 weeks' PMA Early inhaled steroids (< 2 weeks) vs placebo (among all randomised) | RR 0.97 [0.62, 1.52] | 5 studies · 429 participants | Moderate Downgraded: risk of bias |
Death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36 weeks' PMA Early inhaled steroids (< 2 weeks) vs placebo (among all randomised) | RR 0.86 [0.75, 0.99] | 6 studies · 1285 participants | Moderate Downgraded: risk of bias |
Early inhaled steroid (< 2 weeks) compared to placebo (among survivors) for preventing chronic lung disease in very low birth weight preterm neonates
Population: Very low birth weight preterm neonates
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
CLD at 36 weeks' PMA Early inhaled steroid (< 2 weeks) vs placebo (among survivors) | RR 0.76 [0.63, 0.93] | 6 studies · 1088 participants | Moderate |