Cochrane · systematic review · CD011921
Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants
Nasuf, AWA, Ojha, S, Dorling, J · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 6 · 85.7%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Oropharyngeal colostrum (OPC) compared to control (water, saline, or no intervention) in preterm infants
Population: preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of necrotising enterocolitis (NEC) Oropharyngeal colostrum (OPC) vs control (water, saline, or no intervention) | RR 1.42 [0.5, 4.02] | 6 studies · 335 participants | Very low Downgraded: risk of bias |
Incidence of late‐onset sepsis Oropharyngeal colostrum (OPC) vs control (water, saline, or no intervention) | RR 0.86 [0.56, 1.33] | 6 studies · 335 participants | Very low Downgraded: risk of bias |
Death before discharge to home Oropharyngeal colostrum (OPC) vs control (water, saline, or no intervention) | RR 0.76 [0.34, 1.71] | 6 studies · 335 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Days to full enteral feed Oropharyngeal colostrum (OPC) vs control (water, saline, or no intervention) | no estimate extracted | 6 studies · 335 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Length of hospital stay (days) Oropharyngeal colostrum (OPC) vs control (water, saline, or no intervention) | no estimate extracted | 4 studies · 293 participants | Very low Downgraded: risk of bias |
Pneumonia Oropharyngeal colostrum (OPC) vs control (water, saline, or no intervention) | RR 2.08 [0.54, 8.06] | 3 studies · 57 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Reported adverse effects Oropharyngeal colostrum (OPC) vs control (water, saline, or no intervention) | no estimate extracted | 6 studies · 335 participants | Very low Downgraded: risk of bias |