Cochrane · systematic review · CD010239
Lower versus higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth
Lui, K, Jones, LJ, Foster, JP, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 6 · 85.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Lower versus higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth
Population: preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality, near term corrected age or discharge Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth | RR 1.05 [0.68, 1.63] | 10 studies · 914 participants | Low Downgraded: imprecision |
Neurodevelopmental disability Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth | RR 0.82 [0.49, 1.35] | 2 studies · 208 participants | Low Downgraded: imprecision, inconsistency |
Intubation in the delivery room Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth | RR 0.98 [0.82, 1.18] | 9 studies · 875 participants | Low Downgraded: imprecision |
Severe retinopathy of prematurity (≥ stage 3) Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth | RR 0.57 [0.24, 1.36] | 4 studies · 453 participants | Low Downgraded: imprecision |
Severe intraventricular haemorrhage (grade 3 or 4) Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth | RR 0.93 [0.51, 1.71] | 6 studies · 596 participants | Low Downgraded: imprecision |
Necrotising enterocolitis Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth | RR 0.98 [0.51, 1.87] | 8 studies · 807 participants | Low Downgraded: imprecision |
Chronic lung disease (36 weeks' corrected age) Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth | RR 0.91 [0.72, 1.14] | 9 studies · 862 participants | Very low Downgraded: imprecision, inconsistency |