Cochrane · systematic review · CD003313
Immunoglobulin for alloimmune hemolytic disease in neonates
Zwiers, C, Scheffer‐Rath, MEA, Lopriore, E, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 57.1%Low 1 · 14.3%Moderate 2 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Intravenous immunoglobulin plus phototherapy compared to phototherapy alone for alloimmune hemolytic disease in neonates
Population: neonates with alloimmune hemolytic disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Use of ET (≥ 1); all studies Intravenous immunoglobulin plus phototherapy vs phototherapy alone | RR 0.35 [0.25, 0.49] | 9 studies · 658 participants | Very low Downgraded: risk of bias, imprecision |
Use of ET (≥ 1); placebo‐controlled studies Intravenous immunoglobulin plus phototherapy vs phototherapy alone | RR 0.98 [0.48, 1.98] | 2 studies · 172 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
ETs performed per infant; all studies Intravenous immunoglobulin plus phototherapy vs phototherapy alone | no estimate extracted | 9 studies · 658 participants | Very low Downgraded: risk of bias, imprecision |
ETs performed per infant; placebo‐controlled studies Intravenous immunoglobulin plus phototherapy vs phototherapy alone | no estimate extracted | 2 studies · 172 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Use of top‐up transfusion in 1st week of life; all studies Intravenous immunoglobulin plus phototherapy vs phototherapy alone | RR 1.05 [0.65, 1.69] | 4 studies · 378 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Use of top‐up transfusion after 1st week of life; all studies Intravenous immunoglobulin plus phototherapy vs phototherapy alone | RR 1.16 [0.97, 1.38] | 7 studies · 507 participants | Very low Downgraded: risk of bias, imprecision |
Maximum total serum bilirubin (µmol/L); all studies Intravenous immunoglobulin plus phototherapy vs phototherapy alone | no estimate extracted | 6 studies · 451 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |