evidence/gaps
Cochrane · systematic review · CD012181

Antibiotics at the time of removal of central venous catheter to reduce morbidity and mortality in newborn infants

McMullan, RL, Gordon, A · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library

NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 100%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Antibiotics on removal of central venous catheter compared with no antibiotics

Population: newborn infants undergoing removal of central venous catheter
5 questions
OutcomeEffectEvidenceStatus / GRADE
Late‐onset blood steam infection
Antibiotics on removal of central venous catheter vs no antibiotics
RR 0.09 [0.01, 1.6]1 study · 88 participantsLow
Downgraded: risk of bias, imprecision
Neonatal mortality
Antibiotics on removal of central venous catheter vs no antibiotics
no estimate extracted1 study · 88 participantsLow
Downgraded: risk of bias
All‐cause mortality before hospital discharge
Antibiotics on removal of central venous catheter vs no antibiotics
no estimate extracted1 study · 88 participantsLow
Downgraded: risk of bias
Infection‐related mortality before hospital discharge
Antibiotics on removal of central venous catheter vs no antibiotics
no estimate extracted1 study · 88 participantsLow
Downgraded: risk of bias
Central line‐associated blood stream infection
Antibiotics on removal of central venous catheter vs no antibiotics
RR 0.09 [0.01, 1.6]1 study · 88 participantsLow
Downgraded: risk of bias, imprecision