Cochrane · systematic review · CD013171
Lipid emulsions for parenterally fed term and late preterm infants
Kapoor, V, Malviya, MN, Soll, R · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
17
current version
GRADE rated
13
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 4 · 23.5%Very low 9 · 52.9%Low 4 · 23.5%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Fish oil LE compared to non‐fish oil LE in infants with surgical conditions for parenterally fed term and late preterm infants
Population: parenterally fed term and late preterm infants with surgical conditions
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) Pure F‐LE vs S‐LE Fish oil LE vs non‐fish oil LE | RR 1.11 [0.08, 15.28] | 1 study · 19 participants | Very low Downgraded: imprecision |
PNALD/cholestasis (any definition) Fish oil LE vs non‐fish oil LE | RR 1.2 [0.38, 3.76] | 2 studies · 68 participants | Low Downgraded: imprecision |
Culture‐positive sepsis Fish oil LE vs non‐fish oil LE | RR 1.05 [0.47, 2.34] | 2 studies · 51 participants | Very low Downgraded: imprecision |
Hypertriglyceridaemia (definitions varied from > 250 mg/dL to > 300 mg/dL) Fish oil LE vs non‐fish oil LE | no estimate extracted | 2 studies · 68 participants | Ungraded |
Conjugated bilirubin levels Fish oil LE vs non‐fish oil LE | no estimate extracted | 2 studies · 38 participants | Ungraded |
ALP levels Fish oil LE vs non‐fish oil LE | no estimate extracted | 2 studies · 38 participants | Low Downgraded: risk of bias, imprecision |
Death before discharge Fish oil LE vs non‐fish oil LE | no estimate extracted | 2 studies · 68 participants | Ungraded |
Neurodevelopmental outcome (6 and 24 months) Fish oil LE vs non‐fish oil LE | no estimate extracted | 1 study · 10 participants | Ungraded |
Fish oil LE compared to non‐fish oil LE in infants with cholestasis for parenterally fed term and late preterm infants
Population: parenterally fed term and late preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
PNALD/cholestasis (any definition) MOFS‐LE vs S‐LE Pure F‐LE vs S‐LE Fish oil LE vs non‐fish oil LE | RR 0.54 [0.32, 0.91] | 2 studies · 40 participants | Very low Downgraded: imprecision |
Resolution of PNALD/cholestasis (conjugated bilirubin less than2 mg/dL) Pure F‐LE vs S‐LE Fish oil LE vs non‐fish oil LE | RR 5.6 [0.34, 93.35] | 1 study · 16 participants | Very low Downgraded: imprecision |
Growth rate (g/week) Pure F‐LE vs S‐LE Fish oil LE vs non‐fish oil LE | no estimate extracted | 1 study · 16 participants | Very low Downgraded: imprecision |
Any sepsis (clinical or culture positive (or both)) MOFS‐LE vs S‐LE Pure F‐LE vs S‐LE Fish oil LE vs non‐fish oil LE | RR 1.21 [0.5, 2.92] | 2 studies · 40 participants | Very low Downgraded: imprecision |
Hypertriglyceridaemia Fish oil LE vs non‐fish oil LE | RR 0.79 [0.3, 2.09] | 1 study · 24 participants | Very low Downgraded: imprecision |
Conjugated bilirubin levels Fish oil LE vs non‐fish oil LE | no estimate extracted | 1 study · 24 participants | Low Downgraded: imprecision |
ALP levels (IU/L) Fish oil LE vs non‐fish oil LE | no estimate extracted | 1 study · 24 participants | Low Downgraded: imprecision |
Rate of change of conjugated bilirubin Fish oil LE vs non‐fish oil LE | no estimate extracted | 1 study · 16 participants | Very low Downgraded: imprecision |
Death before discharge Fish oil LE vs non‐fish oil LE | RR 0.24 [0.03, 1.87] | 2 studies · 40 participants | Very low Downgraded: imprecision |