Cochrane · systematic review · CD013145

Human milk‐derived fortifier versus bovine milk‐derived fortifier for prevention of mortality and morbidity in preterm neonates

Premkumar, MH, Pammi, M, Suresh, G · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library

NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 7 · 100%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Comparison

Population: Preterm neonates (< 37 0/7 weeks' gestation) fed exclusively with breast milk
7 questions
OutcomeEffectEvidenceStatus / GRADE
Necrotizing enterocolitis
RR 0.95 [0.2, 4.54]1 study · 125 participantsLow
Downgraded: imprecision
Death
RR 0.711 study · 121 participantsLow
Downgraded: imprecision
Weight (change during intervention) (mean ± SD)
no estimate extracted1 study · 118 participantsLow
Downgraded: imprecision
Length (change during intervention) (mean ± SD)
no estimate extracted1 study · 118 participantsLow
Downgraded: imprecision
Head circumference (change during intervention) (mean ± SD)
no estimate extracted1 study · 118 participantsLow
Downgraded: imprecision
Feeding interruption requiring parenteral nutrition
RR 2.861 study · 125 participantsLow
Downgraded: imprecision
Late‐onset sepsis
RR 0.541 study · 125 participantsLow
Downgraded: imprecision