Cochrane · systematic review · CD011893
Beta‐blockers for prevention and treatment of retinopathy of prematurity in preterm infants
Kaempfen, S, Neumann, RP, Jost, K, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 3 · 42.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Systemic administration of beta‐blockers compared to placebo or no treatment for prevention of retinopathy of prematurity in preterm infants
Population: Prevention of retinopathy of prematurity in preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Severe visual impairment or blindness at 6 to 12 months' corrected age Systemic administration of beta‐blockers vs placebo or no treatment | no estimate extracted | NR | No studies |
Rescue treatment with anti‐VEGF agents Systemic administration of beta‐blockers vs placebo or no treatment | RR 0.32 [0.12, 0.86] | 3 studies · 366 participants | Low |
Treatment with laser photocoagulation or cryotherapy Systemic administration of beta‐blockers vs placebo or no treatment | RR 0.54 [0.32, 0.89] | 3 studies · 366 participants | Low |
Progression to stage 2 with plus disease Systemic administration of beta‐blockers vs placebo or no treatment | RR 0.25 [0.03, 2.16] | 2 studies · 161 participants | Moderate |
Progression to stage 3 ROP Systemic administration of beta‐blockers vs placebo or no treatment | RR 0.6 [0.37, 0.96] | 2 studies · 161 participants | Moderate |
Progression to stage 4 or 5 ROP Systemic administration of beta‐blockers vs placebo or no treatment | RR 0.11 [0.01, 1.96] | 2 studies · 161 participants | Moderate |
Arterial hypotension and/or bradycardia requiring treatment Systemic administration of beta‐blockers vs placebo or no treatment | RR 24.35 [1.32, 448.5] | 3 studies · 366 participants | Low |