Cochrane Review Group

Stroke

108 systematic reviews in Stroke ask 1,248 questions. 22% have no studies to answer them, 21.6% rest on very low certainty evidence and 24% reach moderate or high certainty.

Reviews

108

Questions

1,248

current versions

No studies

22%

Moderate or high

24%

No studies 275 · 22%Ungraded 56 · 4.5%Very low 269 · 21.6%Low 349 · 28%Moderate 216 · 17.3%High 83 · 6.7%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Search questions in Stroke

Thinnest evidence

All no studies and very low questions

Question	Effect	Evidence	Status / GRADE
Pharmacological interventions vs placebo Depression: meeting study criteria for depression at end of treatment (primary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.7 [0.55, 0.88]	8 studies · 1025 participants	Very low
Non‐invasive brain stimulation vs sham non‐invasive brain stimulation and/or usual care Depression: mean scores at end of treatment (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	no estimate extracted	8 studies · 505 participants	Very low
Psychological therapy vs usual care and/or attention control Depression: meeting study criteria for depression at end of treatment (primary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.77 [0.62, 0.95]	6 studies · 521 participants	Very low
Psychological therapy vs usual care and/or attention control Depression: meeting study criteria for depression at end of · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.85 [0.59, 1.21]	3 studies · 201 participants	Very low
Psychological therapy vs usual care and/or attention control Adverse events: death ‐ at end of treatment (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.65 [0.26, 1.66]	9 studies · 889 participants	Very low
Pharmacological interventions vs placebo Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.48 [0.32, 0.7]	6 studies · 511 participants	Very low
Psychological therapy vs usual care and/or attention control Adverse events: all ‐ central nervous system events (e.g. suicidal intentions) (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.87 [0.2, 3.9]	2 studies · 126 participants	Very low
Psychological therapy vs usual care and/or attention control Adverse events: all ‐ other events ‐ not listed above (e.g. fall, too ill) (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.62 [0.13, 3.09]	3 studies · 254 participants	Very low
Pharmacological intervention and psychological therapy (combination) vs a pharmacological intervention and usual care or attention control (single) Depression: mean scores at end of treatment (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	no estimate extracted	3 studies · 278 participants	Very low
Pharmacological intervention and non‐invasive brain stimulation (combination) vs a pharmacological intervention and sham stimulation or usual care (single) Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.95 [0.69, 1.3]	3 studies · 392 participants	Very low
Pharmacological intervention and non‐invasive brain stimulation (combination) vs a pharmacological intervention and sham stimulation or usual care (single) Depression: mean scores at end of treatment (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	no estimate extracted	12 studies · 1055 participants	Very low
Pharmacological intervention and non‐invasive brain stimulation (combination) vs a pharmacological intervention and sham stimulation or usual care (single) Adverse events: death (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 1.06 [0.27, 4.16]	5 studies · 487 participants	Very low

Reviews 108

Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for treating depression after stroke

Allida, SM, Hsieh, C-F, et al. · Cochrane Database of Systematic Reviews · 2023

Stroke

Thinnest evidence

Reviews 108

Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for treating depression after stroke

Haemostatic therapies for stroke due to acute, spontaneous intracerebral haemorrhage

Cerebrolysin for acute ischaemic stroke

Peroxisome proliferator‐activated receptor gamma agonists for preventing recurrent stroke and other vascular events in people with stroke or transient ischaemic attack

Antithrombotic treatment after stroke due to intracerebral haemorrhage

Endovascular therapy versus medical treatment for symptomatic intracranial artery stenosis

Pharmacological interventions for asymptomatic carotid stenosis

Trunk training following stroke

Different types of percutaneous endovascular interventions for acute ischemic stroke

Head impulse, nystagmus, and test of skew examination for diagnosing central causes of acute vestibular syndrome

Oral antiplatelet therapy for acute ischaemic stroke

Patch angioplasty versus primary closure for carotid endarterectomy

Routine or selective carotid artery shunting for carotid endarterectomy (and different methods of monitoring in selective shunting)

Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage

Pharmaceutical interventions for emotionalism after stroke

Occupational therapy for cognitive impairment in stroke patients

Interventions for perceptual disorders following stroke

Action observation for upper limb rehabilitation after stroke

Repetitive peripheral magnetic stimulation for impairment and disability in people after stroke

Marine‐derived n‐3 fatty acids therapy for stroke

Type of anaesthesia for acute ischaemic stroke endovascular treatment

Percutaneous transluminal angioplasty and stenting for vertebral artery stenosis

Surgical decompression for malignant cerebral oedema after ischaemic stroke

Anticoagulants for acute ischaemic stroke

Patches of different types for carotid patch angioplasty