Cochrane · systematic review · CD003690

Pharmaceutical interventions for emotionalism after stroke

Allida, S, House, A, Hackett, ML · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library

Stroke2 versionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 33.3%Low 3 · 50%Moderate 1 · 16.7%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

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Pharmaceutical interventions compared to placebo for emotionalism after stroke

Population: emotionalism after stroke
6 questions
OutcomeEffectEvidenceStatus / GRADE
Emotionalism (primary outcome)
Pharmaceutical interventions vs placebo
RR 0.26 [0.09, 0.77]1 study · 19 participantsVery low
Downgraded: imprecision
Emotionalism: mean scores at end of treatment ‐ Pathological Laughter and Crying Scale
Pharmaceutical interventions vs placebo
no estimate extracted1 study · 28 participantsLow
Downgraded: imprecision
Depression: Mean scores at end of treatment
Pharmaceutical interventions vs placebo
no estimate extracted2 studies · 72 participantsVery low
Downgraded: imprecision, inconsistency
Cognitive functioning: Mean scores at end of treatment
Pharmaceutical interventions vs placebo
no estimate extracted1 study · 28 participantsLow
Downgraded: risk of bias, imprecision
Activities of daily living: 1. Mean scores at end of treatment
Pharmaceutical interventions vs placebo
no estimate extracted1 study · 28 participantsLow
Downgraded: risk of bias, imprecision
Adverse events: 1. death: at end of treatment
Pharmaceutical interventions vs placebo
RR 0.59 [0.08, 4.5]6 studies · 172 participantsModerate
Downgraded: imprecision