Cochrane · systematic review · CD003690
Pharmaceutical interventions for emotionalism after stroke
Allida, S, House, A, Hackett, ML · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 33.3%Low 3 · 50%Moderate 1 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyPharmaceutical interventions compared to placebo for emotionalism after stroke
Population: emotionalism after stroke
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Emotionalism (primary outcome) Pharmaceutical interventions vs placebo | RR 0.26 [0.09, 0.77] | 1 study · 19 participants | Very low Downgraded: imprecision |
Emotionalism: mean scores at end of treatment ‐ Pathological Laughter and Crying Scale Pharmaceutical interventions vs placebo | no estimate extracted | 1 study · 28 participants | Low Downgraded: imprecision |
Depression: Mean scores at end of treatment Pharmaceutical interventions vs placebo | no estimate extracted | 2 studies · 72 participants | Very low Downgraded: imprecision, inconsistency |
Cognitive functioning: Mean scores at end of treatment Pharmaceutical interventions vs placebo | no estimate extracted | 1 study · 28 participants | Low Downgraded: risk of bias, imprecision |
Activities of daily living: 1. Mean scores at end of treatment Pharmaceutical interventions vs placebo | no estimate extracted | 1 study · 28 participants | Low Downgraded: risk of bias, imprecision |
Adverse events: 1. death: at end of treatment Pharmaceutical interventions vs placebo | RR 0.59 [0.08, 4.5] | 6 studies · 172 participants | Moderate Downgraded: imprecision |
Pharmaceutical interventions compared to placebo for emotionalism after stroke
Population: emotionalism after stroke
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Emotionalism: 50% reduction in emotionalism Pharmaceutical interventions vs placebo | RR 16.5 [1.07, 253.4] | 1 study · 19 participants | Very low Downgraded: imprecision |
Emotionalism: improved score on Center for Neurologic Study ‐ Lability Scale (CNS‐LS) Pharmaceutical interventions vs placebo | RR 1.44 [0.95, 2.19] | 1 study · 28 participants | Low Downgraded: imprecision |
Emotionalism: clinician interview‐based impression of change ‐ improved score Pharmaceutical interventions vs placebo | RR 1.44 [0.95, 2.19] | 1 study · 28 participants | Low Downgraded: imprecision |
Emotionalism: diminished tearfulness Pharmaceutical interventions vs placebo | RR 2.18 [1.29, 3.71] | 3 studies · 164 participants | Moderate Downgraded: risk of bias |
Emotionalism: mean scores at end of treatment ‐ Pathological Laughter and Crying Scale (high score = worse emotionalism) Pharmaceutical interventions vs placebo | no estimate extracted | 1 study · 28 participants | Low Downgraded: imprecision |
Adverse events: 1. death: at end of treatment Pharmaceutical interventions vs placebo | RR 0.59 [0.08, 4.5] | 6 studies · 172 participants | Moderate Downgraded: imprecision |