Cochrane Review Group

Stroke

108 systematic reviews in Stroke ask 1,248 questions. 22% have no studies to answer them, 21.6% rest on very low certainty evidence and 24% reach moderate or high certainty.

Reviews

108

Questions

1,248

current versions

No studies

22%

Moderate or high

24%

No studies 275 · 22%Ungraded 56 · 4.5%Very low 269 · 21.6%Low 349 · 28%Moderate 216 · 17.3%High 83 · 6.7%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Search questions in Stroke

Thinnest evidence

All no studies and very low questions

Question	Effect	Evidence	Status / GRADE
Pharmacological interventions vs placebo Depression: meeting study criteria for depression at end of treatment (primary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.7 [0.55, 0.88]	8 studies · 1025 participants	Very low
Non‐invasive brain stimulation vs sham non‐invasive brain stimulation and/or usual care Depression: mean scores at end of treatment (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	no estimate extracted	8 studies · 505 participants	Very low
Psychological therapy vs usual care and/or attention control Depression: meeting study criteria for depression at end of treatment (primary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.77 [0.62, 0.95]	6 studies · 521 participants	Very low
Psychological therapy vs usual care and/or attention control Depression: meeting study criteria for depression at end of · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.85 [0.59, 1.21]	3 studies · 201 participants	Very low
Psychological therapy vs usual care and/or attention control Adverse events: death ‐ at end of treatment (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.65 [0.26, 1.66]	9 studies · 889 participants	Very low
Pharmacological interventions vs placebo Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.48 [0.32, 0.7]	6 studies · 511 participants	Very low
Psychological therapy vs usual care and/or attention control Adverse events: all ‐ central nervous system events (e.g. suicidal intentions) (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.87 [0.2, 3.9]	2 studies · 126 participants	Very low
Psychological therapy vs usual care and/or attention control Adverse events: all ‐ other events ‐ not listed above (e.g. fall, too ill) (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.62 [0.13, 3.09]	3 studies · 254 participants	Very low
Pharmacological intervention and psychological therapy (combination) vs a pharmacological intervention and usual care or attention control (single) Depression: mean scores at end of treatment (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	no estimate extracted	3 studies · 278 participants	Very low
Pharmacological intervention and non‐invasive brain stimulation (combination) vs a pharmacological intervention and sham stimulation or usual care (single) Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.95 [0.69, 1.3]	3 studies · 392 participants	Very low
Pharmacological intervention and non‐invasive brain stimulation (combination) vs a pharmacological intervention and sham stimulation or usual care (single) Depression: mean scores at end of treatment (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	no estimate extracted	12 studies · 1055 participants	Very low
Pharmacological intervention and non‐invasive brain stimulation (combination) vs a pharmacological intervention and sham stimulation or usual care (single) Adverse events: death (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 1.06 [0.27, 4.16]	5 studies · 487 participants	Very low