Cochrane Review Group

Stroke

108 systematic reviews in Stroke ask 1,248 questions. 22% have no studies to answer them, 21.6% rest on very low certainty evidence and 24% reach moderate or high certainty.

Reviews

108

Questions

1,248

current versions

No studies

22%

Moderate or high

24%

No studies 275 · 22%Ungraded 56 · 4.5%Very low 269 · 21.6%Low 349 · 28%Moderate 216 · 17.3%High 83 · 6.7%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Search questions in Stroke

Thinnest evidence

All no studies and very low questions

Question	Effect	Evidence	Status / GRADE
Pharmacological interventions vs placebo Depression: meeting study criteria for depression at end of treatment (primary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.7 [0.55, 0.88]	8 studies · 1025 participants	Very low
Non‐invasive brain stimulation vs sham non‐invasive brain stimulation and/or usual care Depression: mean scores at end of treatment (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	no estimate extracted	8 studies · 505 participants	Very low
Psychological therapy vs usual care and/or attention control Depression: meeting study criteria for depression at end of treatment (primary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.77 [0.62, 0.95]	6 studies · 521 participants	Very low
Psychological therapy vs usual care and/or attention control Depression: meeting study criteria for depression at end of · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.85 [0.59, 1.21]	3 studies · 201 participants	Very low
Psychological therapy vs usual care and/or attention control Adverse events: death ‐ at end of treatment (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.65 [0.26, 1.66]	9 studies · 889 participants	Very low
Pharmacological interventions vs placebo Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.48 [0.32, 0.7]	6 studies · 511 participants	Very low
Psychological therapy vs usual care and/or attention control Adverse events: all ‐ central nervous system events (e.g. suicidal intentions) (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.87 [0.2, 3.9]	2 studies · 126 participants	Very low
Psychological therapy vs usual care and/or attention control Adverse events: all ‐ other events ‐ not listed above (e.g. fall, too ill) (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.62 [0.13, 3.09]	3 studies · 254 participants	Very low
Pharmacological intervention and psychological therapy (combination) vs a pharmacological intervention and usual care or attention control (single) Depression: mean scores at end of treatment (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	no estimate extracted	3 studies · 278 participants	Very low
Pharmacological intervention and non‐invasive brain stimulation (combination) vs a pharmacological intervention and sham stimulation or usual care (single) Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 0.95 [0.69, 1.3]	3 studies · 392 participants	Very low
Pharmacological intervention and non‐invasive brain stimulation (combination) vs a pharmacological intervention and sham stimulation or usual care (single) Depression: mean scores at end of treatment (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	no estimate extracted	12 studies · 1055 participants	Very low
Pharmacological intervention and non‐invasive brain stimulation (combination) vs a pharmacological intervention and sham stimulation or usual care (single) Adverse events: death (secondary outcome) · people with depression after stroke Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for… (2023) · Cochrane	RR 1.06 [0.27, 4.16]	5 studies · 487 participants	Very low

Reviews 108

Local versus general anaesthesia for carotid endarterectomy

Rerkasem, A, Orrapin, S, et al. · Cochrane Database of Systematic Reviews · 2021

Stroke

Thinnest evidence

Reviews 108

Local versus general anaesthesia for carotid endarterectomy

Information provision for stroke survivors and their carers

Non‐pharmacological interventions for spatial neglect or inattention following stroke and other non‐progressive brain injury

Endovascular thrombectomy and intra‐arterial interventions for acute ischaemic stroke

Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery

Intravenous thrombolytic treatment and endovascular thrombectomy for ischaemic wake‐up stroke

Environmental enrichment for stroke and other non‐progressive brain injury

The effect of time spent in rehabilitation on activity limitation and impairment after stroke

Interventions for reducing sedentary behaviour in people with stroke

Interventions for altering blood pressure in people with acute subarachnoid haemorrhage

Treatments for unruptured intracranial aneurysms

Dipeptidyl peptidase‐4 inhibitors, glucagon‐like peptide 1 receptor agonists and sodium‐glucose co‐transporter‐2 inhibitors for people with cardiovascular disease: a network meta‐analysis

Organised inpatient (stroke unit) care for stroke: network meta‐analysis

Carotid artery stenting versus endarterectomy for treatment of carotid artery stenosis

Carotid endarterectomy for symptomatic carotid stenosis

Physical fitness training for stroke patients

Pharmacological, psychological and non‐invasive brain stimulation interventions for preventing depression after stroke

Interventions for improving oral health in people after stroke

Mental practice for treating upper extremity deficits in individuals with hemiparesis after stroke

Electromechanical‐assisted training for walking after stroke

Iron chelators for acute stroke

Transcranial direct current stimulation (tDCS) for improving activities of daily living, and physical and cognitive functioning, in people after stroke

Multiple versus fewer antiplatelet agents for preventing early recurrence after ischaemic stroke or transient ischaemic attack

Telerehabilitation services for stroke

Interventions for sexual dysfunction following stroke