Cochrane · systematic review · CD000126
Local versus general anaesthesia for carotid endarterectomy
Rerkasem, A, Orrapin, S, Howard, DPJ, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
StrokeAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 57.1%Moderate 3 · 42.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Local anaesthesia compared with general anaesthesia for carotid endarterectomy
Population: people with symptomatic or asymptomatic carotid disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Any stroke within 30 days of operation (primary outcome) Local anaesthesia vs general anaesthesia | 0.91 [0.66, 1.26] | 13 studies · 4663 participants | Moderate Downgraded: risk of bias |
Death within 30 days of operation Local anaesthesia vs general anaesthesia | OR 0.61 [0.35, 1.06] | 12 studies · 4421 participants | Low Downgraded: risk of bias, imprecision |
Ipsilateral stroke within 30 days of operation Local anaesthesia vs general anaesthesia | OR 1.03 [0.71, 1.48] | 2 studies · 3733 participants | Low Downgraded: risk of bias, imprecision |
Stroke or death within 30 days of operation Local anaesthesia vs general anaesthesia | OR 0.85 [0.62, 1.16] | 11 studies · 4391 participants | Moderate Downgraded: risk of bias |
Myocardial infarction within 30 days of operation Local anaesthesia vs general anaesthesia | OR 1.53 [0.67, 3.47] | 12 studies · 4567 participants | Low Downgraded: risk of bias, imprecision |
Local haemorrhage Local anaesthesia vs general anaesthesia | OR 0.99 [0.79, 1.25] | 6 studies · 4186 participants | Moderate Downgraded: risk of bias |
Arteries shunted Local anaesthesia vs general anaesthesia | OR 0.25 [0.22, 0.29] | 8 studies · 4133 participants | Low Downgraded: risk of bias, imprecision |