Cochrane · systematic review · CD009280
Iron chelators for acute stroke
Van der Loo, LE, Aquarius, R, Teernstra, O, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
StrokeAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
2
Included studies
NR
No studies 2 · 28.6%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 71.4%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Iron chelator versus placebo for adults with acute stroke
Population: adults with acute stroke
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death from all causes at end of scheduled Iron chelator vs placebo | no estimate extracted | 1 study · 291 participants | Low Downgraded: imprecision |
Good neurological outcome (mRS 0 to 2) ( Iron chelator vs placebo | no estimate extracted | 2 studies · 333 participants | Low Downgraded: imprecision |
Serious adverse events (SAE) Iron chelator vs placebo | RR 0.81 [0.57, 1.16] | 1 study · 291 participants | Low Downgraded: imprecision |
Any deaths within the treatment period Iron chelator vs placebo | no estimate extracted | NR | No studies |
Neurologic impairment scale at baseline and at the end of Iron chelator vs placebo | no estimate extracted | 2 studies · 333 participants | Low Downgraded: imprecision |
Relative oedema volume Iron chelator vs placebo | no estimate extracted | 2 studies · 333 participants | Low Downgraded: imprecision |
Quality of life Iron chelator vs placebo | no estimate extracted | NR | No studies |