Cochrane · systematic review · CD003689
Pharmacological, psychological and non‐invasive brain stimulation interventions for preventing depression after stroke
Allida, S, Cox, KL, Hsieh, C-F, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
StrokeAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 7 · 46.7%Very low 8 · 53.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Pharmacological interventions (antidepressants) compared to placebo for preventing depression after stroke
Population: people with stroke
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Depression: meeting study criteria for depression at end treatment (Analysis 1.1) Pharmacological interventions (antidepressants) vs placebo | RR 0.5 [0.37, 0.68] | 9 studies · 734 participants | Very low Downgraded: risk of bias |
Scoring above cut‐off points for a depressive disorder at end of treatment (Analysis 1.2) Pharmacological interventions (antidepressants) vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Depression: mean scores at end of treatment (Analysis 1.4) Pharmacological interventions (antidepressants) vs placebo | no estimate extracted | 4 studies · 100 participants | Very low Downgraded: risk of bias |
Cognition: mean scores at end of treatment (Analysis 1.6) Pharmacological interventions (antidepressants) vs placebo | no estimate extracted | 2 studies · 48 participants | Very low Downgraded: risk of bias |
Activities of daily living: mean scores at end of treatment (Analysis 1.8) Pharmacological interventions (antidepressants) vs placebo | no estimate extracted | 3 studies · 116 participants | Very low Downgraded: risk of bias |
Disability: mean scores at end of treatment (Analysis 1.10) Pharmacological interventions (antidepressants) vs placebo | no estimate extracted | 4 studies · 204 participants | Ungraded |
Adverse events: death ‐ at end of treatment Analysis 1.12 Pharmacological interventions (antidepressants) vs placebo | RR 1.25 [0.32, 4.91] | 9 studies · 496 participants | Very low Downgraded: risk of bias |
Psychological therapy compared to usual care and/or attention control for preventing depression after stroke
Population: people with stroke
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Depression: meeting study criteria for depression at end of treatment (Analysis 2.1) Psychological therapy vs usual care and/or attention control | RR 0.68 [0.49, 0.94] | 2 studies · 607 participants | Very low Downgraded: risk of bias |
Scoring above cut‐off points for a depressive disorder at end of treatment (Analysis 2.2) Psychological therapy vs usual care and/or attention control | no estimate extracted | 0 studies · 0 participants | Ungraded |
Depression: mean scores at end of treatment (Analysis 2.3) Psychological therapy vs usual care and/or attention control | no estimate extracted | 2 studies · 132 participants | Ungraded |
Psychological distress: mean scores at end of treatment (Analysis 2.6) Psychological therapy vs usual care and/or attention control | no estimate extracted | 1 study · 450 participants | Ungraded |
General Health: mean scores at end of treatment (Analysis 2.8) Psychological therapy vs usual care and/or attention control | no estimate extracted | 1 study · 240 participants | Ungraded |
Social activities: mean scores at end of treatment (Analysis 2.10) Psychological therapy vs usual care and/or attention control | no estimate extracted | 2 studies · 690 participants | Very low Downgraded: risk of bias |
Activities of daily living: mean scores at end of treatment (Analysis 2.12) Psychological therapy vs usual care and/or attention control | no estimate extracted | 4 studies · 879 participants | Ungraded |
Adverse events: death ‐ at end of treatment (Analysis 2.16) Psychological therapy vs usual care and/or attention control | RR 1.18 [0.73, 1.91] | 5 studies · 975 participants | Very low Downgraded: risk of bias |