Cochrane Review Group
Oral Health
430 systematic reviews in Oral Health ask 10,375 questions. 13% have no studies to answer them, 11.8% rest on very low certainty evidence and 3.5% reach moderate or high certainty.
Reviews
430
Questions
10,375
current versions
No studies
13%
Moderate or high
3.5%
No studies 1,344 · 13%Ungraded 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Topics
Dental caries264 reviews
5,762 questionsNo studies 5.6% · High 0.7%
Oral and maxillofacial surgery43 reviews
866 questionsNo studies 21.7% · High 0.5%
Orthodontics43 reviews
830 questionsNo studies 22.4% · High 0.4%
Oral medicine and oral cancer34 reviews
1,325 questionsNo studies 12.4% · High 0.1%
Periodontology32 reviews
793 questionsNo studies 18.7% · High 1.5%
Endodontics and dental trauma25 reviews
664 questionsNo studies 16.7% · High 0.2%
Implants and prosthodontics23 reviews
581 questionsNo studies 15% · High 0%
Dental public health and special care13 reviews
288 questionsNo studies 25.3% · High 0%
Pain control and patient management11 reviews
342 questionsNo studies 46.2% · High 1.2%
Temporomandibular disorders and sleep11 reviews
271 questionsNo studies 25.8% · High 0%
Other oral health10 reviews
264 questionsNo studies 17% · High 3.4%
Esthetic dentistry6 reviews
141 questionsNo studies 11.3% · High 0%
Thinnest evidence
All no studies and very low questions| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Partial pulpotomy vs Full (complete) pulpotomy Patient- and clinical-reported outcomes (tooth survival, clinical/radiographic success, pain) · Asymptomatic permanent teeth with deep caries (no symptoms) The effectiveness of partial pulpotomy compared with full pulpotomy in managing deep caries in vital… (2025) | no estimate extracted | 0 studies | No studies |
Calcium vs Control Immediate (24 h) resin-dentin bond strength (MPa) · permanent human teeth with artificial caries-affected dentin · 24 h, Etch-and-Rinse; chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD -0.508 [-8.207, 7.191] | 3 studies | Very low |
Children with dental caries vs Children without dental caries (caries-free) Mean corpuscular volume (MCV) · Children and adolescents (0-18 years; most included reviews focused on <6 years) Association Between Iron Deficiency Anemia and Dental Caries in Children: A Systematic Umbrella Meta-Analysis. (2025) | MD -1.96 [-4.02, 0.10] | 3 studies | Very low |
HIV infection with antiretroviral therapy (ART/HAART) vs HIV-negative individuals Dental caries (presence/absence) · Children and adolescents under 18 years with HIV · Not specified (cross-sectional), Cross-sectional studies Association between antiretroviral therapy and dental caries in children and adolescents with HIV: a… (2025) | OR 2.04 [1.21, 3.42] | 6 studies · 2206 participants | Very low |
HIV infection with antiretroviral therapy (ART/HAART) vs HIV-negative individuals Dental caries severity (dmft index, primary dentition) · Children and adolescents under 18 years with HIV · Not specified (cross-sectional), Cross-sectional studies; dmft index Association between antiretroviral therapy and dental caries in children and adolescents with HIV: a… (2025) | MD 0.92 [-0.09, 1.93] | 5 studies · 1502 participants | Very low |
Cavity liner (calcium hydroxide, glass-ionomer cement, resin-modified calcium silicate/TheraCal LC, hydraulic calcium silicate/MTA or Biodentine, flowable composite, or other liner material) vs No cavity liner or a different liner material Treatment failure · Patients with deep caries lesions in mature or immature permanent (posterior) teeth, with no symptoms or reversible… · >=12 months Efficacy of different cavity liners compared to no cavity lining in managing deep caries in vital permanent… (2025) | No significant difference; 96.5% of treated teeth remained vital | 12 studies · 1184 participants | Very low |
Cavity liner (calcium hydroxide, glass-ionomer cement, resin-modified calcium silicate/TheraCal LC, hydraulic calcium silicate/MTA or Biodentine, flowable composite, or other liner material) vs No cavity liner or a different liner material Postoperative hypersensitivity · Patients with deep caries lesions in mature or immature permanent (posterior) teeth, with no symptoms or reversible… · 7 days to 3 months Efficacy of different cavity liners compared to no cavity lining in managing deep caries in vital permanent… (2025) | No significant difference; minimal pain reported | 9 studies · 1000 participants | Very low |
Secondary (passive/secondhand) smoking exposure during childhood vs No secondary smoking exposure Caries prevalence (early childhood caries) · Preschool children aged <=71 months (caries outcome assessed at 3-6 years) · Caries prevalence at 3-6 years, Overall Secondary Smoking and Early Childhood Caries: A Systematic Review and Meta-Analysis. (2025) | OR 1.77 [1.57, 2.01] | 11 studies · 14,794 participants | Very low |
Cavity liner (calcium hydroxide, glass-ionomer cement, resin-modified calcium silicate/TheraCal LC, hydraulic calcium silicate/MTA or Biodentine, flowable composite, or other liner material) vs No cavity liner or a different liner material Oral health-related quality of life (OHRQoL) · Patients with deep caries lesions in mature or immature permanent (posterior) teeth, with no symptoms or reversible… · >=6 months Efficacy of different cavity liners compared to no cavity lining in managing deep caries in vital permanent… (2025) | no estimate extracted | 0 studies | No studies |
quantitative light-induced fluorescence (QLF) vs reference standard detection of proximal caries · primary teeth with proximal caries · primary dentition Diagnostic accuracy of quantitative light-induced fluorescence in detecting caries of various types and… (2025) | no estimate extracted | 0 studies | No studies |
HIV infection with antiretroviral therapy (ART/HAART) vs HIV-negative individuals Dental caries severity (DMFT index, permanent dentition) · Children and adolescents under 18 years with HIV · Not specified (cross-sectional), Cross-sectional studies; DMFT index Association between antiretroviral therapy and dental caries in children and adolescents with HIV: a… (2025) | MD 0.60 [-0.53, 1.72] | 4 studies · 1390 participants | Very low |
Intervention NR Tooth survival · - The effectiveness of partial pulpotomy compared with full pulpotomy in managing deep caries in vital… (2025) | no estimate extracted | 0 studies | No studies |
Reviews 430
Shear bond strength of metallic brackets bonded to enamel pretreated with CPP-ACP: a systematic review and meta-analysis of in vitro studies.
Non-Cochranefull textintervention15 included studies
3 questions
Strategies to integrate oral health into primary care: a systematic review.
Non-Cochranefull textintervention75 included studies
8 questions
Oral-health-related quality of life in adolescents: umbrella review.
Non-Cochranefull textaetiology22 included studies
42 questions
White spot lesions, plaque accumulation and salivary caries-associated bacteria in clear aligners compared to fixed orthodontic treatment. A systematic review and meta- analysis.
Non-Cochranefull textintervention14 included studies
9 questions
Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and Meta-analysis.
Non-Cochranefull textaetiology41 included studies
32 questions
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis.
Non-Cochranefull textprognostic23 included studies
12 questions
Comparative efficacy of materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth: A systematic review and meta-analysis.
Non-Cochranefull textintervention21 included studies
19 questions
The effectiveness and safety of botulinum toxin injections for the treatment of sialorrhea with Parkinson's disease: a systematic review and meta-analysis.
Non-Cochranefull textintervention8 included studies
6 questions
Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review and meta-analysis.
Non-Cochranefull textaetiology13 included studies
8 questions
Multivariable prediction models of caries increment: a systematic review and critical appraisal.
Non-Cochranefull textprognostic22 included studies
203 questions
Is there an association between periodontal disease and root caries? A systematic review and meta-analysis.
Non-Cochranefull textaetiology4 included studies
1 questions
Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo studies.
Non-Cochranefull textaetiology18 included studies
38 questions
The bi-directional relationship between growth stunting and early childhood caries: a rapid review.
Non-Cochranefull textaetiology9 included studies
13 questions
Antibiotic prophylaxis for preventing bacterial endocarditis following dental procedures
Cochranefull textintervention
5 questions
Full‐mouth treatment modalities (within 24 hours) for periodontitis in adults
Cochranefull textintervention
16 questions
Treatment of periodontitis for glycaemic control in people with diabetes mellitus
Cochranefull textintervention
10 questions
Single versus multiple visits for endodontic treatment of permanent teeth
Cochranefull textintervention
12 questions
Local interventions for the management of alveolar osteitis (dry socket)
Cochranefull textintervention
52 questions
Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis
Cochranefull textintervention
11 questions
Oral care measures for preventing nursing home‐acquired pneumonia
Cochranefull textintervention
9 questions
Interventions for managing medication‐related osteonecrosis of the jaw
Cochranefull textintervention
19 questions
School dental screening programmes for oral health
Cochranefull textintervention
21 questions
Sealants for preventing dental caries in primary teeth
Cochranefull textintervention
28 questions
Psychological therapies for temporomandibular disorders (TMDs)
Cochranefull textintervention
28 questions
Preprocedural mouth rinses for preventing transmission of infectious diseases through aerosols in dental healthcare providers
Cochranefull textintervention
56 questions