Non-Cochrane · intervention · PM37393280
Shear bond strength of metallic brackets bonded to enamel pretreated with CPP-ACP: a systematic review and meta-analysis of in vitro studies.
Yacout Yomna M, Nabawy Yomna A, El-Harouni Nadia M, et al. · BMC oral health · 2023 · PubMed · doi:10.1186/s12903-023-03103-x
Full textEvery question was extracted from the full text, figures and supplements by two independent LLM extractors, disagreements adjudicated. Rows cite where in the review the value comes from.
Questions
3
current version
GRADE rated
0
No studies
0
Included studies
15
linked below
No studies 0 · 0%Ungraded 3 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Enamel of extracted permanent human teeth | Extracted permanent human teeth (15 studies; 365 CPP-ACP test and 1014 control tooth specimens) |
| Intervention | Enamel pre-treatment with CPP-ACP before bonding metallic orthodontic brackets | CPP-ACP enamel pre-treatment before bonding (paste in 12 studies; solution in 3 studies) |
| Comparison | No enamel pre-treatment before bonding, or treatment with another material | No pre-treatment, or another material (e.g., fluoride varnish/gel, resin infiltration, microabrasion) |
| Outcomes | Shear bond strength (SBS) of metallic orthodontic brackets | Shear bond strength in MPa (reported by all 15 studies) |
| Study designs | In vitro experimental studies on extracted permanent human teeth | In vitro experimental studies (n=15) |
| Timing | Not specified | Not specified (in vitro; thermocycling/aging applied in some studies) |
Search date: 29 March 2023 (from inception of each database to 29 March 2023). Databases: MEDLINE (via PubMed); Scopus; Cochrane Library; Web of Science; Google Scholar (grey literature)
Questions and results
Enamel pre-treatment with CPP-ACP before bonding metallic orthodontic brackets vs No enamel pre-treatment before bonding, or treatment with another material
Population: Extracted permanent human teeth (enamel); sound or demineralized
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Shear bond strength (SBS) of metallic orthodontic brackets Before bonding CPP-ACP enamel pre-treatment before bonding did not significantly affect the shear bond strength of metallic orthodontic brackets (MD 1.163 MPa, 95% CI -0.321 to 2.648; ungraded). Source: Abstract; Results (Results of individual studies and Synthesis of results); Fig. 2 · same question in other reviews | MD 1.163 [-0.321, 2.648] | 15 studies · 1379 participants | Ungraded |
CPP-ACP enamel pre-treatment for prevention of white spot lesions before bonding metallic orthodontic brackets vs No enamel pre-treatment before bonding, or treatment with another material
Population: Sound enamel of extracted permanent human teeth
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Shear bond strength (SBS) of metallic orthodontic brackets Before bonding · Prevention of WSLs (sound enamel) When used to prevent white spot lesions on sound enamel, CPP-ACP pre-treatment did not significantly affect shear bond strength (MD 1.009, 95% CI -0.723 to 2.740; ungraded). Source: Abstract; Results (Results of individual studies and Synthesis of results); Fig. 3 · same question in other reviews | MD 1.009 [-0.723, 2.740] | 7 studies | Ungraded |
CPP-ACP enamel pre-treatment for remineralization of white spot lesions before bonding metallic orthodontic brackets vs No enamel pre-treatment before bonding, or treatment with another material
Population: Demineralized enamel of extracted permanent human teeth
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Shear bond strength (SBS) of metallic orthodontic brackets Before bonding · Remineralization of WSLs (demineralized enamel) When used to remineralize white spot lesions on demineralized enamel, CPP-ACP pre-treatment did not significantly affect shear bond strength (MD 1.501, 95% CI -0.630 to 3.632; ungraded). Source: Abstract; Results (Results of individual studies and Synthesis of results); Fig. 4 · same question in other reviews | MD 1.501 [-0.630, 3.632] | 9 studies | Ungraded |
AMSTAR 2 appraisal
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | No | No | yes |
| 3Choice of study designs explained | Yes | Yes | yes |
| 4Comprehensive literature searchcritical | Yes | Yes | yes |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | Yes | Yes | yes |
| 7List of excluded studies with reasonscritical | Yes | No | no |
| 8Included studies described in detail | Yes | Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | RCT: N/A · NRSI: Partial Yes | NRSI: Partial Yes · RCT: N/A | no |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | RCT: N/A · NRSI: Yes | NRSI: Yes · RCT: N/A | no |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | Yes | Yes | yes |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | No | No | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Critically Low | yes |
Included primary studies 15
Open as a trial list| Study | Also included by | Outcomes it informs here | Trial PICO | Results |
|---|---|---|---|---|
| Al-Kawari and Al-Jobair 2014 Effect of different preventive agents on bracket shear bond strength: in vitro study. PMID:24678892 | this review only | not stated | not extracted yet | not extracted yet |
| Baka et al. 2016 Effects of remineralization procedures on shear bond strengths of brackets bonded to demineralized enamel surfaces with self-etch systems. PMID:26524389 | this review only | not stated | not extracted yet | not extracted yet |
| Baysal and Uysal 2012 Do enamel microabrasion and casein phosphopeptide-amorphous calcium phosphate affect shear bond strength of orthodontic brackets bonded to… PMID:21787200 | this review only | not stated | not extracted yet | not extracted yet |
| Cehreli et al. 2012 Effects of a fluoride-containing casein phosphopeptide-amorphous calcium phosphate complex on the shear bond strength of orthodontic… PMID:21317209 | this review only | not stated | not extracted yet | not extracted yet |
| Daneshkazemi et al. 2021 Shear bond strength of orthodontic brackets on intact and demineralized enamel after application of resin infiltrant, fluoride varnish and… PMID:33775598 | this review only | not stated | not extracted yet | not extracted yet |
| Farhadian et al. 2017 Effect of CPP-ACP paste with and without CO2 laser irradiation on demineralized enamel microhardness and bracket shear bond strength. PMID:28902250 | this review only | not stated | not extracted yet | not extracted yet |
| Gulec and Goymen 2019 Assessment of the resin infiltration and CPP-ACP applications before orthodontic brackets bonding. PMID:31434834 | this review only | not stated | not extracted yet | not extracted yet |
| Ladhe et al. 2014 Effect of remineralizing agents on bond strength of orthodontic brackets: an in vitro study. PMID:24935482 | this review only | not stated | not extracted yet | not extracted yet |
| Park et al. 2013 The effect of casein phosphopeptide amorphous calcium phosphate on the in vitro shear bond strength of orthodontic brackets. PMID:23504444 | this review only | not stated | not extracted yet | not extracted yet |
| Tabrizi and Cakirer 2011 A comparative evaluation of casein phosphopeptide-amorphous calcium phosphate and fluoride on the shear bond strength of orthodontic… PMID:20651043 | this review only | not stated | not extracted yet | not extracted yet |
| Topsakal and Amuk 2019 Effects of Different Remineralisation Agents and Adhesives Around Orthodontic Brackets: Is There a Relationship Between Remineralisation… PMID:31631193 | this review only | not stated | not extracted yet | not extracted yet |
| Uy et al. 2019 Remineralization Potential of Calcium and Phosphate-based Agents and Their Effects on Bonding of Orthodontic Brackets. PMID:31165104 | this review only | not stated | not extracted yet | not extracted yet |
| Uysal et al. 2011 Do fluoride and casein phosphopeptide-amorphous calcium phosphate affect shear bond strength of orthodontic brackets bonded to a… PMID:21261484 | this review only | not stated | not extracted yet | not extracted yet |
| Veli et al. 2016 Effects of different pre-treatment methods on the shear bond strength of orthodontic brackets to demineralized enamel. PMID:25892478 | this review only | not stated | not extracted yet | not extracted yet |
| Xiaojun et al. 2009 Effects of CPP-ACP paste on the shear bond strength of orthodontic brackets. PMID:19705946 | this review only | not stated | not extracted yet | not extracted yet |