Topic in Oral Health

Orthodontics

Malocclusion, fixed and removable appliances, and tooth movement.

43 systematic reviews in Orthodontics ask 830 questions. 22.4% have no studies to answer them, 14.7% rest on very low certainty evidence and 4% reach moderate or high certainty.

Reviews
43
Questions
830
current versions
No studies
22.4%
Moderate or high
4%
No studies 186 · 22.4%Ungraded 410 · 49.4%Very low 122 · 14.7%Low 79 · 9.5%Moderate 30 · 3.6%High 3 · 0.4%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Superelastic NiTi arch wire vs Multistrand stainless steel arch wire
Root resorption · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
Initial arch wires used in orthodontic treatment with fixed appliances (2024) · Cochrane
Root resorption: not reported0 studiesNo studies
Facemask (RME) or modified facemask vs Other non-surgical orthodontic treatments (mini maxillary protractor, Pushing Splints, modified tandem, Reverse Forsus, reverse Twin Block, reverse chin cup, tongue appliance, Frankel III)
Perceived need for surgery in adulthood · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children (2024) · Cochrane
SoF3: Perceived need for surgery in adulthood - Not measured.0 studiesNo studies
Fixed orthodontic treatment with fixed (multibracket) appliances (exposure) vs None (single-group prevalence/incidence estimate)
Incidence of new ICLs (mean number of new lesions per subject) · Patients undergoing fixed orthodontic treatment with fixed (multibracket) appliances, followed for development of new… · During fixed orthodontic treatment (development of new lesions), Overall (random-effects model)
Distribution of initial caries lesions in relation to fixed orthodontic therapy. A systematic review and… (2024)
MEAN 2.29 [1.12, 3.46]5 studies · 208 participantsVery low
Fixed orthodontic treatment with fixed (multibracket) appliances (exposure) vs None (single-group prevalence/incidence estimate)
Prevalence of ICLs (mean number of lesions per subject) · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances · During or after fixed orthodontic treatment (cross-sectional/at debonding), Overall (random-effects model)
Distribution of initial caries lesions in relation to fixed orthodontic therapy. A systematic review and… (2024)
MEAN 2.24 [1.79, 2.70]6 studies · 484 participantsVery low
Fixed orthodontic treatment with fixed (multibracket) appliances (exposure) vs None (single-group prevalence/incidence estimate)
Incidence of new ICLs (proportion of tooth surfaces developing new lesions) · Patients undergoing fixed orthodontic treatment with fixed (multibracket) appliances, followed for development of new… · During fixed orthodontic treatment (development of new lesions), Overall (random-effects model)
Distribution of initial caries lesions in relation to fixed orthodontic therapy. A systematic review and… (2024)
Proportion 0.15 [0.08, 0.26]4 studies · 1890 participantsVery low
Superelastic NiTi arch wire vs Conventional (stabilised) NiTi arch wire
Root resorption · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
Initial arch wires used in orthodontic treatment with fixed appliances (2024) · Cochrane
Root resorption: not reported0 studiesNo studies
Thermoelastic copper NiTi (CuNiTi) arch wire vs Conventional NiTi arch wire
Pain · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
Initial arch wires used in orthodontic treatment with fixed appliances (2024) · Cochrane
Pain: not reported0 studiesNo studies
Superelastic NiTi arch wire vs Conventional (stabilised) NiTi arch wire
Time to alignment · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
Initial arch wires used in orthodontic treatment with fixed appliances (2024) · Cochrane
Time to alignment: not reported0 studiesNo studies
Facemask (RME) or modified facemask vs Other non-surgical orthodontic treatments (mini maxillary protractor, Pushing Splints, modified tandem, Reverse Forsus, reverse Twin Block, reverse chin cup, tongue appliance, Frankel III)
ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment
Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children (2024) · Cochrane
MD 0.11 [-0.54, 0.77]8 studies · 285 participantsVery low
Facemask (RME) or modified facemask vs Surgically-anchored appliance (miniscrews or miniplates)
Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment
Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children (2024) · Cochrane
MD -0.40 [-1.30, 0.50]1 study · 43 participantsVery low
Facemask with rapid maxillary expansion (RME) vs Facemask with alternating rapid maxillary expansion and constriction (Alt-RAMEC)
Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children (2024) · Cochrane
SoF5 (Facemask (Alt-RAMEC) vs facemask (RME)): Overjet - Not measured.0 studiesNo studies
NiTi arch wire of one cross-sectional size vs NiTi arch wire of a different cross-sectional size
Root resorption · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
Initial arch wires used in orthodontic treatment with fixed appliances (2024) · Cochrane
Root resorption: not reported0 studiesNo studies

Reviews 43

The influence of anorexia nervosa on oral health and related parameters potentially relevant to orthodontic treatment: a systematic review and meta-analysis.

Niederau Christian, Alman Eda, et al. · Clinical oral investigations · 2025
Non-Cochranefull textaetiology19 included studies
9 questions

Fluoride mouthrinses for prevention of initial caries in orthodontic patients - a systematic review and meta-analysis.

Sonesson Mikael, Twetman Svante · BMC oral health · 2025
Non-Cochranefull textintervention9 included studies
4 questions

Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children

Owens, D, Watkinson, S, et al. · Cochrane Database of Systematic Reviews · 2024
Cochranefull textintervention
78 questions

Initial arch wires used in orthodontic treatment with fixed appliances

Liu, C, Wei, Z, et al. · Cochrane Database of Systematic Reviews · 2024
Cochranefull textintervention
34 questions

Distribution of initial caries lesions in relation to fixed orthodontic therapy. A systematic review and meta-analysis.

Salerno Claudia, Grazia Cagetti Maria, et al. · European journal of orthodontics · 2024
Non-Cochranefull textaetiology33 included studies
9 questions

Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed Orthodontic Treatment? A Systematic Review.

El Helou Marwan, Chakar Sandra, et al. · The journal of adhesive dentistry · 2024
Non-Cochranefull textintervention12 included studies
33 questions

Remineralization and anti-demineralization effect of orthodontic adhesives on enamel surrounding orthodontic brackets: a systematic review of in vitro studies.

Hamdi Kareem, Elsebaai Ahmed, et al. · BMC oral health · 2024
Non-Cochranefull textintervention25 included studies
12 questions

Retention procedures for stabilising tooth position after treatment with orthodontic braces

Martin, C, Littlewood, SJ, et al. · Cochrane Database of Systematic Reviews · 2023
Cochranefull textintervention
33 questions

Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment

El-Angbawi, A, McIntyre, G, et al. · Cochrane Database of Systematic Reviews · 2023
Cochranefull textintervention
33 questions

Malocclusions and quality of life among adolescents: a systematic review and meta-analysis.

Göranson Emma, Sonesson Mikael, et al. · European journal of orthodontics · 2023
Non-Cochranefull textaetiology14 included studies
2 questions

The efficacy of mouthwashes on oral microorganisms and gingivitis in patients undergoing orthodontic treatment: a systematic review and meta-analysis.

Ren Xiaolin, Zhang Yuhan, et al. · BMC oral health · 2023
Non-Cochranefull textintervention47 included studies
23 questions

Prevention of white spot lesions with fluoride varnish during orthodontic treatment with fixed appliances: a systematic review.

Sonesson Mikael, Twetman Svante · European journal of orthodontics · 2023
Non-Cochranefull textintervention12 included studies
2 questions

White spot lesions, plaque accumulation and salivary caries-associated bacteria in clear aligners compared to fixed orthodontic treatment. A systematic review and meta- analysis.

Raghavan Shailaja, Abu Alhaija Elham S, et al. · BMC oral health · 2023
Non-Cochranefull textintervention14 included studies
9 questions

Changes in the Color and Brightness of White Spots Associated with Orthodontic Treatment 6 Months after the Application of Infiltrative Resins: Systematic Review and Meta-Analysis.

Baptista-Sánchez Hugo, Antonio-Zancajo Laura, et al. · International journal of environmental research and public health · 2022
Non-Cochranefull textintervention4 included studies
9 questions

Orthodontic treatment for posterior crossbites

Ugolini, A, Agostino, P, et al. · Cochrane Database of Systematic Reviews · 2021
Cochranefull textintervention
55 questions

Orthodontic treatment for crowded teeth in children

Turner, S, Harrison, JE, et al. · Cochrane Database of Systematic Reviews · 2021
Cochranefull textintervention
44 questions

Interventions for promoting the eruption of palatally displaced permanent canine teeth, without the need for surgical exposure, in children aged 9 to 14 years

Benson, PE, Atwal, A, et al. · Cochrane Database of Systematic Reviews · 2021
Cochranefull textintervention
27 questions

Efficacy of resin infiltration to mask post-orthodontic or non-post-orthodontic white spot lesions or fluorosis - a systematic review and meta-analysis.

Bourouni S, Dritsas K, et al. · Clinical oral investigations · 2021
Non-Cochranefull textintervention11 included studies
11 questions

Efficacy of sealants and bonding materials during fixed orthodontic treatment to prevent enamel demineralization: a systematic review and meta-analysis.

Kamber R, Meyer-Lueckel H, et al. · Scientific reports · 2021
Non-Cochranefull textintervention24 included studies
19 questions

Impact of Aligners and Fixed Appliances on Oral Health during Orthodontic Treatment: A Systematic Review and Meta-Analysis.

Oikonomou Elissaios, Foros Petros, et al. · Oral health & preventive dentistry · 2021
Non-Cochranefull textintervention21 included studies
20 questions

Is Bleaching Effective in Managing Post-orthodontic White-spot Lesions? A Systematic Review.

Gizani Sotiria, Kloukos Dimitrios, et al. · Oral health & preventive dentistry · 2020
Non-Cochranefull textintervention15 included studies
9 questions

Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment

Benson, PE, Parkin, N, et al. · Cochrane Database of Systematic Reviews · 2019
Cochranefull textintervention
26 questions

Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted

Day, PF, Duggal, M, et al. · Cochrane Database of Systematic Reviews · 2019
Cochranefull textintervention
18 questions

Adhesives for fixed orthodontic brackets

Mandall, NA, Hickman, J, et al. · Cochrane Database of Systematic Reviews · 2018
Cochranefull textintervention
6 questions

Orthodontic treatment for prominent upper front teeth (Class II malocclusion) in children and adolescents

Batista, KBSL, Thiruvenkatachari, B, et al. · Cochrane Database of Systematic Reviews · 2018
Cochranefull textintervention
49 questions