Non-Cochrane · aetiology · PM36995692
Malocclusions and quality of life among adolescents: a systematic review and meta-analysis.
Göranson Emma, Sonesson Mikael, Naimi-Akbar Aron, et al. · European journal of orthodontics · 2023 · PubMed · doi:10.1093/ejo/cjad009
Full textEvery question was extracted from the full text, figures and supplements by two independent LLM extractors, disagreements adjudicated. Rows cite where in the review the value comes from.
Questions
2
current version
GRADE rated
2
No studies
0
Included studies
14
linked below
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 100%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adolescents aged 10-19 years with and without malocclusion | Adolescents 10-19 years (13 studies, n=13,864; meta-analysis subset 11-14 years, n=3,672) |
| Intervention | Malocclusion (any index), assessed as an exposure | Malocclusion; DAI the most common index (10/13 studies); meta-analysis used DAI>25 |
| Comparison | No malocclusion | No malocclusion (DAI <= 25 in the meta-analysis) |
| Outcomes | Oral health-related quality of life (OHRQoL) | OHRQoL; CPQ the most common instrument (10/13 studies); meta-analysis used CPQ 11-14-ISF:16 (4 studies) |
| Study designs | Studies controlling for confounders (non-randomized/observational studies); RCTs eligible for baseline data | 13 cross-sectional non-randomized studies (6 low, 7 moderate risk of bias); 4 pooled in meta-analysis |
| Timing | Not specified | Cross-sectional (single timepoint) |
Search date: 15 June 2022 (complementary Google Scholar search 26 January 2023). Databases: PubMed, Cochrane Library, CINAHL, Scopus, Web of Science (plus PROSPERO, ClinicalTrials.gov, Google Scholar, and reference lists)
Questions and results
Malocclusion vs No malocclusion
Population: Adolescents aged 10-19 years
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Impaired OHRQoL measured with CPQ 11-14 (quantitative synthesis / meta-analysis) Malocclusion (DAI) probably increases the prevalence of impaired OHRQoL (CPQ 11-14) by about 15% in adolescents (RR/PR 1.15, 95% CI 1.12-1.18; moderate certainty). Source: Figure 3 (forest plot); Table 2 (GRADE summary of findings); Results - quantitative synthesis (meta-analysis) · same question in other reviews | Rate/prevalence ratio (RR/PR) 1.15 [1.12, 1.18] | 4 studies · 3672 participants | Moderate Downgraded: indirectness |
Oral health-related quality of life (OHRQoL), impaired (qualitative synthesis) Malocclusions probably have a negative effect on OHRQoL in adolescents, after adjustment for confounders (moderate certainty). Source: Table 2 (GRADE summary of findings); Results - Certainty of evidence · same question in other reviews | Impaired OHRQoL, qualitative synthesis: relative effect not estimable across the 13 studies (13,864 participants); moderate quality of evidence (GRADE). | 13 studies · 13864 participants | Moderate Downgraded: indirectness |
Included primary studies 14
Open as a trial list| Study | Also included by | Outcomes it informs here | Trial PICO | Results |
|---|---|---|---|---|
| Paula 2012 matched by author and year (probable) | 2 other reviews | not stated | not extracted yet | not extracted yet |
| Mohamed 2018 Oral clinical status and oral health-related quality of life: is socioeconomic position a mediator or a moderator? PMID:30152041 | 1 other review | Oral health-related quality of life (OHRQoL), impaired (qualitative synthesis) | not extracted yet | not extracted yet |
| Bernabe 2009 Comparison of the discriminative ability of the generic and condition‐specific forms of the Child‐OIDP index: a study on children with… DOI:10.1111/j.1600-0528.2008.00456.x | this review only | Oral health-related quality of life (OHRQoL), impaired (qualitative synthesis) | not extracted yet | not extracted yet |
| Bittencourt 2017 Negative effect of malocclusion on the emotional and social well-being of Brazilian adolescents: a population-based study DOI:10.1093/ejo/cjx020 | this review only | Impaired OHRQoL measured with CPQ 11-14 (quantitative synthesis / meta-analysis) | not extracted yet | not extracted yet |
| da Rosa 2016 Association of malocclusion, happiness, and oral health–related quality of life (<scp>OHRQoL</scp>) in schoolchildren DOI:10.1111/jphd.12111 | this review only | Impaired OHRQoL measured with CPQ 11-14 (quantitative synthesis / meta-analysis) | not extracted yet | not extracted yet |
| Dalla Nora 2022 matched by author and year (probable) | this review only | Oral health-related quality of life (OHRQoL), impaired (qualitative synthesis) | not extracted yet | not extracted yet |
| Dimberg 2016 DOI:10.3109/00016357.2015.1059485 | this review only | Oral health-related quality of life (OHRQoL), impaired (qualitative synthesis) | not extracted yet | not extracted yet |
| Feldens 2016 Clarifying the Impact of Untreated and Treated Dental Caries on Oral Health-Related Quality of Life among Adolescents DOI:10.1159/000447095 | this review only | Impaired OHRQoL measured with CPQ 11-14 (quantitative synthesis / meta-analysis) | not extracted yet | not extracted yet |
| Foster Page 2012 Factors influencing adolescents' oral health‐related quality of life (<scp>OHRQ</scp>o<scp>L</scp>) DOI:10.1111/ipd.12011 | this review only | Oral health-related quality of life (OHRQoL), impaired (qualitative synthesis) | not extracted yet | not extracted yet |
| Kavaliauskiene 2020 Relationships of Dental Caries and Malocclusion with Oral Health-Related Quality of Life in Lithuanian Adolescents Aged 15 to 18 Years: A… PMID:32521600 | this review only | Oral health-related quality of life (OHRQoL), impaired (qualitative synthesis) | not extracted yet | not extracted yet |
| Paula 2012 Cerebral blood flow velocity in healthy term infants. PMID:2012106 | this review only | Oral health-related quality of life (OHRQoL), impaired (qualitative synthesis) | not extracted yet | not extracted yet |
| Roque 2021 matched by author and year (probable) | this review only | Oral health-related quality of life (OHRQoL), impaired (qualitative synthesis) | not extracted yet | not extracted yet |
| Simoes 2017 Impact of Malocclusion on Oral Health-Related Quality of Life of 8-12 Years Old Schoolchildren in Southern Brazil DOI:10.1590/0103-6440201701278 | this review only | Impaired OHRQoL measured with CPQ 11-14 (quantitative synthesis / meta-analysis) | not extracted yet | not extracted yet |
| Sun 2017 The factors that influence the oral health-related quality of life in 12-year-old children: baseline study of a longitudinal research. PMID:28784126 | this review only | Oral health-related quality of life (OHRQoL), impaired (qualitative synthesis) | not extracted yet | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match).