Same question across reviews · CL0071
aetiology :: Unclassified intervention -> Quality of life
ProposalThis cluster groups questions by review type, intervention category and outcome domain. It is a proposal pending human validation, so questions in it may differ in population, comparator or timing.
Reviews
7
Questions
79
current versions
GRADE rated
17
Review overlap (CCA)
0.001
over all included studies of these reviews, not this question only
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Low edentulism prevalence vs Not applicable OHRQoL sum score transformed to 0-100 · Community-dwelling adults aged 60 years or older · Baseline for longitudinal studies, Low edentulism prevalence Association between oral health-related quality of life and structural determinants of health among elderly… (2025) | There were no statistically significant differences reported in the OHRQoL sum scores based on prevalence of edentulism. | NR | Ungraded |
High edentulism prevalence vs Not applicable OHRQoL sum score transformed to 0-100 · Community-dwelling adults aged 60 years or older · Baseline for longitudinal studies, High edentulism prevalence Association between oral health-related quality of life and structural determinants of health among elderly… (2025) | There were no statistically significant differences reported in the OHRQoL sum scores based on prevalence of edentulism. | NR | Ungraded |
Country-level periodontal disease prevalence (Global Burden of Disease) vs Low vs high periodontal disease prevalence Oral health-related quality of life (OHRQoL sum score, transformed 0-100) · Community-dwelling elderly persons aged ≥60 years · Across periodontal disease prevalence categories Association between oral health-related quality of life and structural determinants of health among elderly… (2025) | No statistically significant difference in OHRQoL based on periodontal disease prevalence (Fig. 4b). | NR | Ungraded |
Human Development Index (HDI) vs Higher vs lower HDI categories Oral health-related quality of life (OHRQoL sum score, transformed 0-100) · Community-dwelling elderly persons aged ≥60 years · High HDI Association between oral health-related quality of life and structural determinants of health among elderly… (2025) | MEAN 79.9 [74.4, 85.5] | NR | Ungraded |
High periodontal-disease prevalence vs Not applicable OHRQoL sum score transformed to 0-100 · Community-dwelling adults aged 60 years or older · Baseline for longitudinal studies, High periodontal-disease prevalence Association between oral health-related quality of life and structural determinants of health among elderly… (2025) | There were no statistically significant differences reported in the OHRQoL sum scores based on periodontal disease prevalence. | NR | Ungraded |
Country-level unemployment rate vs Higher vs lower unemployment-rate categories Oral health-related quality of life (OHRQoL sum score, transformed 0-100) · Community-dwelling elderly persons aged ≥60 years · Across unemployment-rate categories Association between oral health-related quality of life and structural determinants of health among elderly… (2025) | No statistically significant difference in OHRQoL based on unemployment rate (Fig. 2c). | NR | Ungraded |
Unemployment rate vs Not applicable OHRQoL sum score transformed to 0-100 · Community-dwelling adults aged 60 years or older · Baseline for longitudinal studies Association between oral health-related quality of life and structural determinants of health among elderly… (2025) | There was no statistically significant difference in OHRQoL based on unemployment rate. | NR | Ungraded |
Health expenditure per capita vs Higher vs lower per-capita health expenditure categories Oral health-related quality of life (OHRQoL sum score, transformed 0-100) · Community-dwelling elderly persons aged ≥60 years · Across per-capita health expenditure categories Association between oral health-related quality of life and structural determinants of health among elderly… (2025) | No statistically significant difference in OHRQoL based on per-capita health expenditure (Fig. 3a). | NR | Ungraded |
Health expenditure per capita vs Not applicable OHRQoL sum score transformed to 0-100 · Community-dwelling adults aged 60 years or older · Baseline for longitudinal studies Association between oral health-related quality of life and structural determinants of health among elderly… (2025) | There was no statistically significant difference in OHRQoL based on per capita expenditure on health care. | NR | Ungraded |
Country-level edentulism prevalence (Global Burden of Disease) vs Low vs high edentulism prevalence Oral health-related quality of life (OHRQoL sum score, transformed 0-100) · Community-dwelling elderly persons aged ≥60 years · Across edentulism prevalence categories Association between oral health-related quality of life and structural determinants of health among elderly… (2025) | No statistically significant difference in OHRQoL based on edentulism prevalence (Fig. 4c). | NR | Ungraded |
Human Development Index (HDI) vs Higher vs lower HDI categories Oral health-related quality of life (OHRQoL sum score, transformed 0-100) · Community-dwelling elderly persons aged ≥60 years · Medium HDI Association between oral health-related quality of life and structural determinants of health among elderly… (2025) | MEAN 63.5 [54.3, 72.7] | NR | Ungraded |
Out-of-pocket health expenditure vs Lower vs higher out-of-pocket expenditure categories Oral health-related quality of life (OHRQoL sum score, transformed 0-100) · Community-dwelling elderly persons aged ≥60 years · Highest out-of-pocket expenditure Association between oral health-related quality of life and structural determinants of health among elderly… (2025) | MEAN 67.5 [58.5, 76.5] | NR | Ungraded |
Low periodontal-disease prevalence vs Not applicable OHRQoL sum score transformed to 0-100 · Community-dwelling adults aged 60 years or older · Baseline for longitudinal studies, Low periodontal-disease prevalence Association between oral health-related quality of life and structural determinants of health among elderly… (2025) | There were no statistically significant differences reported in the OHRQoL sum scores based on periodontal disease prevalence. | NR | Ungraded |
Out-of-pocket health expenditure vs Lower vs higher out-of-pocket expenditure categories Oral health-related quality of life (OHRQoL sum score, transformed 0-100) · Community-dwelling elderly persons aged ≥60 years · Lowest out-of-pocket expenditure Association between oral health-related quality of life and structural determinants of health among elderly… (2025) | MEAN 83.9 [75.2, 92.6] | NR | Ungraded |
Country-level dental caries prevalence (Global Burden of Disease) vs Low vs high dental caries prevalence Oral health-related quality of life (OHRQoL sum score, transformed 0-100) · Community-dwelling elderly persons aged ≥60 years · Low dental caries prevalence Association between oral health-related quality of life and structural determinants of health among elderly… (2025) | MEAN 81.5 [76.5, 86.6] | NR | Ungraded |
High dental-caries prevalence vs Not applicable OHRQoL sum score transformed to 0-100 · Community-dwelling adults aged 60 years or older · Baseline for longitudinal studies, High dental-caries prevalence Association between oral health-related quality of life and structural determinants of health among elderly… (2025) | 71.40 [64.16, 78.63] | NR | Ungraded |
Human Development Index (HDI) vs Higher vs lower HDI categories Oral health-related quality of life (OHRQoL sum score, transformed 0-100) · Community-dwelling elderly persons aged ≥60 years · Very high HDI Association between oral health-related quality of life and structural determinants of health among elderly… (2025) | MEAN 78.4 [71.1, 85.8] | NR | Ungraded |
Disability (developmental, intellectual, or sensory) vs Persons without disabilities Overall oral health-related quality of life (OHRQoL) impact (self- and proxy/caregiver-reported) · Persons with disabilities (children and adults with autism, Down syndrome, cerebral palsy, hearing impairment, or… · Cross-sectional Disabilities and Disparities in Oral Health-Related Quality of Life: A Systematic Review and Meta-Analysis… (2024) | Narrative synthesis (no pooled estimate). PWDs reported reduced functional, emotional, and social well-being and greater oral-health impact on quality of life. AlJameel 2021 (Down syndrome): 34.9% of children and 46%… | NR | Ungraded |
Edentulism (complete or partial missing teeth) vs Individuals without edentulism Oral health-related quality of life (dichotomous: poor vs not) · Indian elderly Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | Edentulism and QoL (dichotomous): edentulism did not affect OHRQoL (Shivakumar 2018). Single study, not pooled. | 1 study | Ungraded |
Safe housing / favorable household conditions vs Unsafe housing / poor household conditions Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years) Oral-health-related quality of life in adolescents: umbrella review. (2023) | having parents who can provide dental care and safe housing are positive predictors for OHRQoL. Socioeconomic factors related to the area of residence, satisfaction with oral health and dental care were shown to be… | NR | Ungraded |
Malocclusion vs No malocclusion Impaired OHRQoL measured with CPQ 11-14 (quantitative synthesis / meta-analysis) · Adolescents aged 10-19 years Malocclusions and quality of life among adolescents: a systematic review and meta-analysis. (2023) | Rate/prevalence ratio (RR/PR) 1.15 [1.12, 1.18] | 4 studies · 3672 participants | Moderate |
Malocclusion (assessed by DAI, IOTN or WHO criteria) vs Individuals without malocclusion Oral health-related quality of life (continuous), measured by GOHAI · Indian children, adolescents and adults Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | Malocclusion and QoL (continuous, GOHAI): no significant difference in OHRQoL between individuals with and without malocclusion (Appukuttan 2016). Single study, not pooled. | 1 study | Ungraded |
Bruxism vs Individuals without bruxism (non-bruxers) Oral health-related quality of life (continuous), measured by OHIP-14 · Indian children and adults Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | Bruxism and QoL (continuous, OHIP-14): bruxers have poorer OHRQoL than non-bruxers (Thetakala 2018, Suguna 2020). Two studies, 284 individuals; not pooled. | 2 studies · 284 participants | Ungraded |
Traumatic dental injury (dental trauma) vs No dental trauma Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years) Oral-health-related quality of life in adolescents: umbrella review. (2023) | The impact of dental trauma sequelae on OHRQoL in adolescents was observed in five systematic reviews [31-35]. The studies show that uncomplicated traumatic injuries do not have a negative impact on the OHRQoL of… | 5 studies | Ungraded |
Dental caries (assessed by DMFT/deft/dmft, WHO criteria or PUFA) vs Individuals without dental caries Oral health-related quality of life (dichotomous: poor vs not) · Indians across all ages (children, adolescents, adults, elderly) · Adolescents 10-19 years (dichotomous) Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | OR 3.92 [2.06, 7.48] | 5 studies · 3171 participants | Ungraded |
Older age vs Younger age Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years) Oral-health-related quality of life in adolescents: umbrella review. (2023) | Worse oral health status, older age, female sex and worse socioeconomic status were significantly associated with worse OHRQoL. [Body: the influence of religion and age on OHRQoL is unknown; Biological data such as… | NR | Ungraded |
Operative treatment of dental caries lesions vs No caries treatment Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years) Oral-health-related quality of life in adolescents: umbrella review. (2023) | the operative treatment of caries lesions has a positive effect on OHRQoL, despite the low quality of evidence [9]. There is low evidence that the OHRQoL of children and adolescents improved following caries… | NR | Ungraded |
Periodontal disease assessed by loss of attachment (LOA / clinical attachment loss) vs Individuals without periodontal disease (by LOA) Oral health-related quality of life (continuous), measured by OHIP-14 / OIDP · Indian adults and elderly (police, teachers, general and institutionalised populations) Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | SMD -0.04 [-2.01, 1.92] | 4 studies · 3414 participants | Very low |
Periodontal disease assessed by Community Periodontal Index vs No periodontal disease assessed by community periodontal index Poor oral health-related quality of life · Indians Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | no estimate extracted | 3 studies · 1345 participants | Very low |
Malocclusion vs No malocclusion Poor oral health-related quality of life · Indians Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | OR 5.44 [1.61, 18.39] | 6 studies · 3720 participants | Very low |
Periodontal disease assessed by Community Periodontal Index (CPI) vs Individuals without periodontal disease (by CPI) Oral health-related quality of life (dichotomous: poor vs not) · Indian adults and elderly (general, police, teachers, institutionalised) Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | Periodontal disease (CPI) vs none: studies show inconsistency; two studies showed poor QoL (Nagarajappa 2015, Saxena 2018), one no significant association (Shivakumar 2018); 1345 participants, 3 observational studies;… | 3 studies · 1345 participants | Very low |
Gingivitis (assessed by gingival index or WHO criteria) vs Individuals without gingivitis Oral health-related quality of life (continuous), measured by GOHAI / OHIP-14 · Indians (adolescents, adults, elderly, children) Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | Gingivitis and QoL (continuous): GOHAI - one study found poorer QoL (Appukuttan 2016, P<0.05), one no significant association (Marya 2020, P=0.08); OHIP-14 - no impact (Sreela 2020, P=0.0762). Not pooled. | 3 studies | Ungraded |
Periodontal disease assessed by Community Periodontal Index (CPI) vs Individuals without periodontal disease (by CPI) Oral health-related quality of life (continuous), measured by OHIP-14 / OIDP · Indian adults and elderly (general, police, teachers, institutionalised) Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | SMD -0.18 [-0.53, 0.18] | 4 studies · 3064 participants | Very low |
Dental caries (assessed by DMFT/deft/dmft, WHO criteria or PUFA) vs Individuals without dental caries Oral health-related quality of life (continuous), measured by GOHAI · Indians across all ages (children, adolescents, adults, elderly) Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | Dental caries and QoL (GOHAI): all three studies (Appukuttan 2016, Rekhi 2018, Rekhi 2015) found decayed teeth associated with poorer QoL (P<0.05); not pooled. | 3 studies | Ungraded |
Dental caries vs Absence/lower severity of dental caries Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years) Oral-health-related quality of life in adolescents: umbrella review. (2023) | The impact of dental caries on OHRQoL was addressed in five systematic reviews [9, 26, 34, 36, 37]. Three articles report that the greater the severity of the carious lesion, the worse the impact on OHRQoL in… | 5 studies | Ungraded |
Female sex vs Male sex Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years) Oral-health-related quality of life in adolescents: umbrella review. (2023) | Worse oral health status, older age, female sex and worse socioeconomic status were significantly associated with worse OHRQoL. [Conclusion: gender and skin color did not have their level of impact clarified.] | NR | Ungraded |
Edentulism (complete or partial missing teeth) vs Individuals without edentulism Oral health-related quality of life (continuous), measured by GOHAI / WHOQoL · Indian elderly Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | Edentulism and QoL (continuous, GOHAI/WHOQoL): one study reported edentulism negatively influenced QoL (Marina 2019), one found no effect (Appukuttan 2016). Not pooled. | 2 studies | Ungraded |
Dental caries (assessed by DMFT/deft/dmft, WHO criteria or PUFA) vs Individuals without dental caries Oral health-related quality of life (continuous), measured by ECOHIS / Michigan Oral Health QoL · Indian children aged 3-5 years · Children 3-5 years (ECOHIS/Michigan, continuous) Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | Subgroup children 3-5 years (continuous, ECOHIS/Michigan): early childhood caries significantly associated with poorer OHRQoL (Singh N 2020, Ghanghas 2019, Jaggi 2019); not pooled. | 3 studies | Ungraded |
Malocclusion (assessed by DAI, IOTN or WHO criteria) vs Individuals without malocclusion Oral health-related quality of life (dichotomous: poor vs not) · Indian children, adolescents and adults Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | OR 5.44 [1.61, 18.39] | 6 studies · 3720 participants | Very low |
Completion of orthodontic treatment vs Untreated / never received orthodontic treatment Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years) Oral-health-related quality of life in adolescents: umbrella review. (2023) | Adolescents who had never received orthodontic treatment had a greater impact on quality of life compared to patients who had already completed treatment [34, 40, 44-46]. Orthodontic treatment during childhood or… | NR | Ungraded |
Prosthetic need vs Individuals without prosthetic need Oral health-related quality of life (dichotomous: poor vs not) · Indian elderly and general-population adults Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | Prosthetic need vs none: both included studies showed a significant association with poor QoL (Nagarajappa 2015, Shivakumar 2018); 950 participants, 2 observational studies; Moderate certainty (Fig 1 GRADE SoF). No… | 2 studies · 950 participants | Moderate |
Tooth loss / edentulism vs No tooth loss Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years) Oral-health-related quality of life in adolescents: umbrella review. (2023) | Toothache, DMT and tooth loss have a high impact on OHRQoL in adolescentes [26]. | NR | Ungraded |
Edentulism (complete or partial missing teeth) vs Individuals without edentulism Oral health-related quality of life (continuous), measured by OHIP-14 · Indian elderly Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | Edentulism and QoL (continuous, OHIP-14): no significant association between individuals with and without edentulism (Ajai 2020). Single study, not pooled. | 1 study | Ungraded |
Bruxism vs No bruxism Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years) Oral-health-related quality of life in adolescents: umbrella review. (2023) | While dental erosion and bruxism have not been shown to impact the quality of life of adolescents [26]. Bruxism does not impact quality of life in children and adolescentes [33]. | NR | Ungraded |
Prosthetic need vs No prosthetic need Poor oral health-related quality of life · Indians Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | no estimate extracted | 2 studies · 950 participants | Moderate |
Dental fluorosis (assessed by TFI or WHO criteria) vs Individuals without dental fluorosis Oral health-related quality of life (continuous), measured by OIDP / CPQ11-14 · Indian children and young adults Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | Dental fluorosis and QoL (continuous, OIDP/CPQ11-14): a significant difference between individuals with and without fluorosis on OHRQoL (Nagarajappa 2015, Shyam 2020). Two studies, 3000 individuals; not pooled. | 2 studies · 3000 participants | Ungraded |
Dental erosion vs No dental erosion Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years) Oral-health-related quality of life in adolescents: umbrella review. (2023) | While dental erosion and bruxism have not been shown to impact the quality of life of adolescents [26]. | NR | Ungraded |
Temporomandibular disorder (TMD) vs No temporomandibular disorder Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years) Oral-health-related quality of life in adolescents: umbrella review. (2023) | dental caries, malocclusion [9, 26-30], TMD [9], dental trauma (TDI) [32, 34, 35], poor brushing [36], toothache [26], periodontal disease [34] and edentulism [9] negatively affect the quality of life of adolescents. | NR | Ungraded |
Malocclusion (assessed by DAI, IOTN or WHO criteria) vs Individuals without malocclusion Oral health-related quality of life (continuous), measured by OHIP-14 / ECOHIS / FIS · Indian children, adolescents and adults Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | Malocclusion and QoL (continuous, OHIP-14/ECOHIS/FIS): malocclusion had a significant negative influence on OHRQoL (Vinayagamoorthy 2020, Mary 2019). Not pooled. | 2 studies | Ungraded |
Periodontal disease assessed by Community Periodontal Index (CPI) vs Individuals without periodontal disease (by CPI) Oral health-related quality of life (continuous), measured by GOHAI · Indian adults and elderly (general, police, teachers, institutionalised) Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | Periodontal disease (CPI) and QoL (continuous, GOHAI): CPI scores negatively correlated with QoL in one study (Rekhi 2016); no significant relation in another (Marya 2020, P>0.05). Not pooled. | 2 studies | Ungraded |