Topic in Oral Health

Oral medicine and oral cancer

Oral cancer and potentially malignant disorders, mucosal disease, dry mouth, and taste disorders.

34 systematic reviews in Oral medicine and oral cancer ask 1,325 questions. 12.4% have no studies to answer them, 15.8% rest on very low certainty evidence and 3% reach moderate or high certainty.

Reviews

Questions

1,325

current versions

No studies

12.4%

Moderate or high

No studies 164 · 12.4%Ungraded 841 · 63.5%Very low 209 · 15.8%Low 72 · 5.4%Moderate 38 · 2.9%High 1 · 0.1%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Search questions in Oral medicine and oral cancer

Thinnest evidence

All no studies and very low questions

Question	Effect	Evidence	Status / GRADE
Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment Hospital admission (length of stay) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) Interventions for managing oral submucous fibrosis (2024) · Cochrane	The trials did not measure hospital admission.	0 studies	No studies
Physiotherapy (tongue-spatula jaw exercises) vs No active treatment Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · 3 to 6 months Interventions for managing oral submucous fibrosis (2024) · Cochrane	MD 0.50 [-7.72, 8.72]	1 study · 24 participants	Very low
Topical curcumin gel vs Topical aloe vera gel Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · Less than 3 months Interventions for managing oral submucous fibrosis (2024) · Cochrane	MD -0.64 [-3.91, 2.63]	1 study · 60 participants	Very low
Buccal fat pad pedicle plus placental extract vs Buccal fat pad pedicle alone Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · Less than 3 months Interventions for managing oral submucous fibrosis (2024) · Cochrane	MD 7.80 [4.90, 10.70]	1 study · 10 participants	Very low
Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment Participant-reported resumption of normal eating, chewing and speech · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) Interventions for managing oral submucous fibrosis (2024) · Cochrane	SoF: participant-reported resumption of normal eating, chewing and speech - outcome not reported by included studies.	0 studies	No studies
Vasodilators (isoxsuprine, xanthinol nicotinate) vs Placebo or no active treatment Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · 3 to 6 months Interventions for managing oral submucous fibrosis (2024) · Cochrane	MD 4.04 [-1.93, 10.02]	2 studies · 85 participants	Very low
Buccal fat pad graft vs Extended nasolabial flap Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · More than 6 months Interventions for managing oral submucous fibrosis (2024) · Cochrane	MD 6.50 [-10.72, 23.72]	1 study · 8 participants	Very low
Pentoxifylline vs Spirulina Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · 3 to 6 months Interventions for managing oral submucous fibrosis (2024) · Cochrane	MD 0.50 [-6.60, 7.60]	1 study · 40 participants	Very low
Buccal fat pad graft vs Extended nasolabial flap Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · Less than 3 months Interventions for managing oral submucous fibrosis (2024) · Cochrane	MD -7.25 [-14.19, -0.31]	1 study · 8 participants	Very low
Surgery plus Heister jaw opener vs Surgery plus wooden tongue depressors Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · More than 6 months Interventions for managing oral submucous fibrosis (2024) · Cochrane	MD 0.60 [0.01, 1.19]	1 study · 50 participants	Very low
Abdominal dermal fat graft vs Nasolabial flap Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · 3 to 6 months Interventions for managing oral submucous fibrosis (2024) · Cochrane	MD -14.87 [-19.93, -9.81]	1 study · 30 participants	Very low
Buccal fat pad graft vs Extended nasolabial flap Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · 3 to 6 months Interventions for managing oral submucous fibrosis (2024) · Cochrane	MD 6.00 [-11.36, 23.36]	1 study · 8 participants	Very low

Reviews 34

Interventions for managing oral submucous fibrosis

Jones, A, Veale, B, et al. · Cochrane Database of Systematic Reviews · 2024

Oral medicine and oral cancer

Thinnest evidence

Reviews 34

Interventions for managing oral submucous fibrosis

Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies.

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment

The effect of gum chewing on xerostomia and salivary flow rate in elderly and medically compromised subjects: a systematic review and meta-analysis.

White spot lesions, plaque accumulation and salivary caries-associated bacteria in clear aligners compared to fixed orthodontic treatment. A systematic review and meta- analysis.

Association of Early Childhood Caries with Bitter Taste Receptors: A Meta-Analysis of Genome-Wide Association Studies and Transcriptome-Wide Association Study.

Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy

Clinical assessment for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults

Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions

Interventions for treating oral lichen planus: corticosteroid therapies

Interventions for managing halitosis

Interventions for managing taste disturbances

Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy

Interventions for treating oral leukoplakia to prevent oral cancer

Interventions for treating burning mouth syndrome

Parasympathomimetic drugs for the treatment of salivary gland dysfunction due to radiotherapy

Interventions for the treatment of oral and oropharyngeal cancers: targeted therapy and immunotherapy

Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy

Screening programmes for the early detection and prevention of oral cancer

Interventions for the management of dry mouth: non‐pharmacological interventions

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers)

Interventions for erosive lichen planus affecting mucosal sites

Interventions for preventing oral mucositis for patients with cancer receiving treatment

Interventions for the management of dry mouth: topical therapies