Non-Cochrane · prognostic · PM37679718
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis.
Manchanda Sheetal, Sardana Divesh, Peng Simin, et al. · BMC oral health · 2023 · PubMed · doi:10.1186/s12903-023-03346-8
Full textEvery question was extracted from the full text, figures and supplements by two independent LLM extractors, disagreements adjudicated. Rows cite where in the review the value comes from.
Questions
12
current version
GRADE rated
1
No studies
0
Included studies
23
linked below
No studies 0 · 0%Ungraded 11 · 91.7%Very low 0 · 0%Low 0 · 0%Moderate 1 · 8.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Children younger than 6 years, caries-free (no cavitated or non-cavitated lesions) at recruitment | Caries-free children <6 years (n=3,313 recruited caries-free; 12 studies; 3,010 in the OR analysis) |
| Intervention | Presence of mutans streptococci in oral samples at baseline | Mutans streptococci present at baseline (12 studies) |
| Comparison | Absence of mutans streptococci in oral samples at baseline | Mutans streptococci absent at baseline (12 studies) |
| Outcomes | Development of any cavitated or non-cavitated carious lesion in primary dentition; future caries experience (dmft/dmfs) | Future caries development (binary, OR; 12 studies); future caries experience (continuous, SMD; 4 studies) |
| Study designs | Longitudinal observational (cohort) studies | Longitudinal observational cohort studies (n=12) |
| Timing | At least 6 months follow-up | 6 months (n=2); 1 year (n=4); 2 years (n=4); 31 months median (n=1); 42 months (n=1) |
Search date: 2022-11-15. Databases: Medline (via Ovid); Embase (via Ovid); Scopus; PubMed; CINAHL; Web of Science; grey literature (OpenGrey, Google Scholar)
Questions and results
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline
Population: Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Development of any (cavitated or non-cavitated) carious lesion 1 year · Follow-up: 1 year At 1 year of follow-up, baseline mutans streptococci were associated with higher odds of developing caries (OR 4.37; ungraded subgroup). Source: Fig. 6 (subgroup by length of follow-up); Results 'Additional analysis' · same question in other reviews | OR 4.37 [3.50, 5.45] | 4 studies · 2016 participants | Ungraded |
Development of any (cavitated or non-cavitated) carious lesion 6 months to 3.5 years · Microbiological assessment: quantitative (culture/CFU counting) In studies using quantitative (culture-based) microbiological assessment, baseline mutans streptococci were associated with higher odds of developing caries (OR 3.82; ungraded subgroup). Source: Fig. 4 (subgroup by microbiological assessment method); Results 'Additional analysis' · same question in other reviews | OR 3.82 [2.01, 7.26] | 6 studies · 732 participants | Ungraded |
Development of any (cavitated or non-cavitated) carious lesion 6 months to 3.5 years · Sample: saliva When mutans streptococci were detected in saliva, baseline presence was associated with higher odds of developing caries (OR 3.92; ungraded subgroup). Source: Fig. 5 (subgroup by sample used for detection); Results 'Additional analysis' · same question in other reviews | OR 3.92 [3.20, 4.80] | 9 studies · 2577 participants | Ungraded |
Development of any (cavitated or non-cavitated) carious lesion 2 years · Follow-up: 2 years At 2 years of follow-up, baseline mutans streptococci were associated with higher odds of developing caries (OR 2.53; ungraded subgroup). Source: Fig. 6 (subgroup by length of follow-up); Results 'Additional analysis' · same question in other reviews | OR 2.53 [1.22, 5.23] | 4 studies · 297 participants | Ungraded |
Development of any (cavitated or non-cavitated) carious lesion 6 months to 3.5 years · Overall Preschool children with mutans streptococci at baseline probably have about four times higher odds of developing early childhood caries (OR 4.13; moderate certainty). Source: Table 2 (GRADE evidence profile); Fig. 2 (forest plot); Results 'Synthesis of results'; Abstract · same question in other reviews | OR 4.13 [3.33, 5.12] 282 [230, 336] more per 1,000 | 12 studies · 3010 participants | Moderate |
Development of any (cavitated or non-cavitated) carious lesion 6 months to 3.5 years · Sample: plaque When mutans streptococci were detected in plaque, baseline presence was associated with higher odds of developing caries (OR 5.16; ungraded subgroup). Source: Fig. 5 (subgroup by sample used for detection); Results 'Additional analysis' · same question in other reviews | OR 5.16 [2.99, 8.91] | 5 studies · 736 participants | Ungraded |
Development of any (cavitated or non-cavitated) carious lesion 2.7 years (31 months median) · Follow-up: 2.7 years (31 months median) At about 2.7 years (single study), baseline mutans streptococci were associated with higher odds of developing caries (OR 33.00, very wide CI; ungraded subgroup). Source: Fig. 6 (subgroup by length of follow-up); Results 'Additional analysis' · same question in other reviews | OR 33.00 [3.18, 342.26] | 1 study · 28 participants | Ungraded |
Future caries experience (dmft/dmfs) 1 to 2 years · Overall Children with mutans streptococci at baseline had a greater future caries experience (SMD 0.85, a large effect; ungraded). Source: Fig. 3 (SMD forest plot); Results 'Synthesis of results'; Abstract · same question in other reviews | SMD 0.85 [0.33, 1.37] | 4 studies · 1323 participants | Ungraded |
Development of any (cavitated or non-cavitated) carious lesion 3.5 years (42 months) · Follow-up: 3.5 years (42 months) At 3.5 years (single study), baseline mutans streptococci were associated with higher odds of developing caries (OR 4.23; ungraded subgroup). Source: Fig. 6 (subgroup by length of follow-up); Results 'Additional analysis' · same question in other reviews | OR 4.23 [2.49, 7.18] | 1 study · 366 participants | Ungraded |
Development of any (cavitated or non-cavitated) carious lesion 6 months · Follow-up: 6 months At 6 months of follow-up, baseline mutans streptococci were associated with higher odds of developing caries (OR 4.65; ungraded subgroup). Source: Fig. 6 (subgroup by length of follow-up); Results 'Additional analysis' · same question in other reviews | OR 4.65 [2.01, 10.76] | 2 studies · 303 participants | Ungraded |
Development of any (cavitated or non-cavitated) carious lesion 6 months to 3.5 years · Microbiological assessment: semi-quantitative (Dentocult/commercial kit) In studies using semi-quantitative (Dentocult/kit) microbiological assessment, baseline mutans streptococci were associated with higher odds of developing caries (OR 4.36; ungraded subgroup). Source: Fig. 4 (subgroup by microbiological assessment method); Results 'Additional analysis' · same question in other reviews | OR 4.36 [3.53, 5.39] | 6 studies · 2278 participants | Ungraded |
Mutans streptococci detected in plaque or saliva at baseline vs No mutans streptococci detected in plaque or saliva at baseline
Population: Children younger than 6 years with caries-free primary dentition
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Development of carious lesions 6 months to 3.5 years · Overall sample sensitivity analysis Across the sample-based sensitivity analysis, mutans streptococci at baseline were associated with higher odds of developing caries. Source: Fig. 5 · same question in other reviews | OR 4.04 [3.33, 4.90] | 12 studies · 3313 participants | Ungraded |
Included primary studies 23
Open as a trial list| Study | Also included by | Outcomes it informs here | Trial PICO | Results |
|---|---|---|---|---|
| Alaluusua 1983 Streptococcus mutans establishment and dental caries experience in children from 2 to 4 years old. PMID:6581521 | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Alaluusua and Renkonen 1983 Streptococcus mutans establishment and dental caries experience in children from 2 to 4 years old DOI:10.1111/j.1600-0722.1983.tb00845.x | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Ansai 2000 Influence of colonization with mutans streptococci on caries risk in Japanese preschool children: 24 month survival analysis. PMID:11048304 | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Ansai et al. 2000 matched by author and year (probable) | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Fujiwara 1991 Caries prevalence and salivary mutans streptococci in 0-2-year-old children of Japan. PMID:1864067 | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Fujiwara et al. 1991 Caries prevalence and salivary mutans streptococci in 0–2‐year‐old children of Japan DOI:10.1111/j.1600-0528.1991.tb00131.x | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Gao 2014 Role of microbiological factors in predicting early childhood caries. PMID:25198002 | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Grindefjord 1995 Caries development in children from 2.5 to 3.5 years of age: a longitudinal study. PMID:8556747 | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Grindefjord et al. 1995 Caries Development in Children from 2.5 to 3.5 Years of Age: A Longitudinal Study DOI:10.1159/000262113 | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Litt 1995 Multidimensional causal model of dental caries development in low-income preschool children. PMID:7480616 | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Litt et al. 1995 matched by author and year (probable) | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Meurman 2010 Factors associated with caries increment: a longitudinal study from 18 months to 5 years of age. PMID:20975269 | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Meurman and Pienihaekkinen 2010 Factors Associated with Caries Increment: A Longitudinal Study from 18 Months to 5 Years of Age DOI:10.1159/000320717 | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| O'Sullivan 1996 Caries experience and mutans streptococci as indicators of caries incidence. PMID:8897528 | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| O'Sullivan and Thibodeau 1996 matched by author and year (probable) | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Seki 2003 Evaluation of mutans streptococci in plaque and saliva: correlation with caries development in preschool children. PMID:12735923 | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Seki 2006 Effect of mixed mutans streptococci colonization on caries development. PMID:16390341 | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Seki et al. 2003 Evaluation of mutans streptococci in plaque and saliva: correlation with caries development in preschool children DOI:10.1016/s0300-5712(03)00033-2 | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Seki et al. 2006 Effect of mixed mutans streptococci colonization on caries development DOI:10.1111/j.1399-302x.2005.00253.x | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Tenovuo 1990 Caries development in children in relation to the presence of mutans streptococci in dental plaque and of serum antibodies against whole… PMID:2293894 | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Tenovuo et al. 1990 Caries Development in Children in Relation to the Presence of Mutans Streptococci in Dental Plaque and of Serum Antibodies against Whole… DOI:10.1159/000261240 | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Wendt 1996 Analysis of caries-related factors in infants and toddlers living in Sweden. PMID:8739147 | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |
| Wendt et al. 1996 Analysis of caries-related factors in infants and toddlers living in Sweden DOI:10.3109/00016359609006019 | this review only | Development of any (cavitated or non-cavitated) carious lesion | not extracted yet | not extracted yet |