Non-Cochrane · prognostic · PM41840623
Prognostic value of NLR versus PLR and LMR in patients with oral squamous cell carcinoma: a meta-analysis.
Xu Jian, Wu Fan, Jiang Yuhuang, et al. · BMC oral health · 2026 · PubMed · doi:10.1186/s12903-026-08098-9
Findings
Population Patients with oral squamous cell carcinoma
44 findings
| High pretreatment NLR | Low pretreatment NLR | Disease-free survival (restricted mean survival time difference) 1 year | RMSTD (years) 0.07 [0.02, 0.12] GRADE not reported 3 studies |
| High pretreatment NLR | Low pretreatment NLR | Overall survival Region non-Asia | HR 1.80 [1.30, 2.49] GRADE not reported 3 studies |
| High pretreatment NLR | Low pretreatment NLR | Disease-free survival Cohort size >=300 | HR 1.58 [1.35, 1.85] GRADE not reported 5 studies |
| High pretreatment NLR | Low pretreatment NLR | Overall survival (restricted mean survival time difference) 4 years | RMSTD (years) 0.51 [0.33, 0.70] GRADE not reported 3 studies |
| High pretreatment NLR | Low pretreatment NLR | Overall survival (restricted mean survival time difference) 2 years | RMSTD (years) 0.15 [0.08, 0.22] GRADE not reported 3 studies |
| High pretreatment NLR | Low pretreatment NLR | Disease-free survival (restricted mean survival time difference) 2 years | RMSTD (years) 0.22 [0.11, 0.34] GRADE not reported 3 studies |
| High pretreatment NLR | Low pretreatment NLR | Overall survival Region Asia | HR 1.54 [1.39, 1.71] GRADE not reported 16 studies |
| High pretreatment NLR | Low pretreatment NLR | Overall survival Age <60 years | HR 1.47 [1.31, 1.65] GRADE not reported 8 studies |
| High pretreatment NLR | Low pretreatment NLR | Overall survival (restricted mean survival time difference) 3 years | RMSTD (years) 0.33 [0.20, 0.45] GRADE not reported 3 studies |
| High pretreatment NLR | Low pretreatment NLR | Disease-free survival Region Asia | HR 1.70 [1.33, 2.19] GRADE not reported 10 studies |
| High pretreatment NLR | Low pretreatment NLR | Disease-free survival Cut-off <3 | HR 1.68 [1.21, 2.32] GRADE not reported 8 studies |
| High pretreatment NLR | Low pretreatment NLR | Overall survival | HR 1.61 [1.47, 1.76] GRADE not reported 19 studies · 8152 participants |
| High pretreatment NLR | Low pretreatment NLR | Overall survival Age >=60 years | HR 1.80 [1.50, 2.16] GRADE not reported 9 studies |
| High pretreatment NLR | Low pretreatment NLR | Disease-free survival (restricted mean survival time difference) 3 years | RMSTD (years) 0.40 [0.25, 0.55] GRADE not reported 3 studies |
| High pretreatment NLR | Low pretreatment NLR | Overall survival (restricted mean survival time difference) 1 year | RMSTD (years) 0.03 [-0.01, 0.07] GRADE not reported 3 studies |
| High pretreatment NLR | Low pretreatment NLR | Disease-free survival | HR 1.64 [1.31, 2.05] GRADE not reported 11 studies · 3262 participants |
| High pretreatment NLR | Low pretreatment NLR | Overall survival Cut-off >=3 | HR 1.90 [1.63, 2.23] GRADE not reported 6 studies |
| High pretreatment NLR | Low pretreatment NLR | Disease-free survival Cut-off >=3 | HR 1.51 [1.23, 1.86] GRADE not reported 3 studies |
| High pretreatment NLR | Low pretreatment NLR | Overall survival Cohort size >=300 | HR 1.70 [1.44, 2.00] GRADE not reported 12 studies |
| High pretreatment NLR | Low pretreatment NLR | Disease-free survival Age >=60 years | HR 1.65 [1.15, 2.37] GRADE not reported 7 studies |
| High pretreatment NLR | Low pretreatment NLR | Overall survival Cut-off <3 | HR 1.48 [1.32, 1.65] GRADE not reported 13 studies |
| High pretreatment NLR | Low pretreatment NLR | Disease-free survival (restricted mean survival time difference) 5 years | RMSTD (years) 0.74 [0.47, 1.00] GRADE not reported 3 studies |
| High pretreatment NLR | Low pretreatment NLR | Disease-free survival Age <60 years | HR 1.55 [1.27, 1.88] GRADE not reported 4 studies |
| High pretreatment NLR | Low pretreatment NLR | Disease-free survival (restricted mean survival time difference) 4 years | RMSTD (years) 0.57 [0.37, 0.77] GRADE not reported 3 studies |
| High pretreatment NLR | Low pretreatment NLR | Disease-free survival Cohort size <300 | HR 1.65 [1.02, 2.67] GRADE not reported 6 studies |
| High pretreatment NLR | Low pretreatment NLR | Overall survival Cohort size <300 | HR 1.94 [1.46, 2.57] GRADE not reported 7 studies |
| High pretreatment NLR | Low pretreatment NLR | Overall survival (restricted mean survival time difference) 5 years | RMSTD (years) 0.71 [0.42, 1.00] GRADE not reported 3 studies |
| High pretreatment PLR | Low pretreatment PLR | Overall survival Region Asia | HR 1.58 [1.17, 2.14] GRADE not reported 10 studies |
| High pretreatment PLR | Low pretreatment PLR | Overall survival Cohort size >=300 | HR 1.42 [0.95, 2.13] GRADE not reported 5 studies |
| High pretreatment PLR | Low pretreatment PLR | Overall survival Age <65 years | HR 1.25 [1.02, 1.52] GRADE not reported 4 studies |
| High pretreatment PLR | Low pretreatment PLR | Overall survival Cut-off <150 | HR 1.12 [0.88, 1.43] GRADE not reported 5 studies |
| High pretreatment PLR | Low pretreatment PLR | Overall survival Age >=65 years | HR 1.28 [0.97, 1.69] GRADE not reported 5 studies |
| High pretreatment PLR | Low pretreatment PLR | Disease-free survival | HR 1.45 [0.97, 2.15] GRADE not reported 4 studies |
| High pretreatment PLR | Low pretreatment PLR | Overall survival | HR 1.50 [1.15, 1.94] GRADE not reported 11 studies · 3189 participants |
| High pretreatment PLR | Low pretreatment PLR | Overall survival Cut-off >=150 | HR 1.72 [1.17, 2.52] GRADE not reported 6 studies |
| High pretreatment PLR | Low pretreatment PLR | Overall survival Cohort size <300 | HR 1.45 [1.10, 1.90] GRADE not reported 6 studies |
| High pretreatment LMR | Low pretreatment LMR | Overall survival Cut-off <4 | HR 0.81 [0.40, 1.63] GRADE not reported 4 studies |
| High pretreatment LMR | Low pretreatment LMR | Overall survival Cohort size <300 | HR 0.72 [0.34, 1.53] GRADE not reported 6 studies |
| High pretreatment LMR | Low pretreatment LMR | Overall survival Age <60 years | HR 0.79 [0.37, 1.72] GRADE not reported 4 studies |
| High pretreatment LMR | Low pretreatment LMR | Overall survival Cohort size >=300 | HR 0.62 [0.48, 0.80] GRADE not reported 4 studies |
| High pretreatment LMR | Low pretreatment LMR | Overall survival | HR 0.70 [0.47, 1.05] GRADE not reported 10 studies · 3127 participants |
| High pretreatment LMR | Low pretreatment LMR | Overall survival Cut-off >=4 | HR 0.63 [0.37, 1.09] GRADE not reported 6 studies |
| High pretreatment LMR | Low pretreatment LMR | Overall survival Age >=60 years | HR 0.57 [0.33, 0.98] GRADE not reported 5 studies |
| High pretreatment LMR | Low pretreatment LMR | Disease-free survival | HR 0.67 [0.46, 0.96] GRADE not reported 2 studies |
Included primary studies 70
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Battista 2024 Effects of renal dopamine receptor and beta-adrenoreceptor blockade on rises in blood angiotensin after haemorrhage, renal ischaemia and… PMID:202430 | 1978 | 4 other reviews | not stated | not extracted yet |
| Chen 2021 Induction of premature parturition in sheep: adrenocorticotrophin and corticosteroid changes during infusion of Synacthen into the foetus. PMID:202133 | 1978 | 3 other reviews | not stated | not extracted yet |
| Wu 2023 Relaxation of smooth muscle following contraction elicited by sympathetic nerve stimulation in vivo. PMID:202357 | 1977 | 3 other reviews | not stated | not extracted yet |
| Furukawa 2019 [Enkephalins--endorphins- endogenous opiate agonists]. PMID:201936 | 1977 | 2 other reviews | not stated | not extracted yet |
| Sano 2018 Correlation of Inflammatory Markers, Survival, and COX2 Expression in Oral Cancer and Implications for Prognosis. PMID:29359615 | 2018 | 2 other reviews | not stated | not extracted yet |
| Wu 2021 The nasal arteries. PMID:202158 | 1978 | 2 other reviews | not stated | not extracted yet |
| Ansarin 2021 Isolated gastric involvement in Crohn's disease. Report of a case simulating scirrhus carcinoma. PMID:202129 | 1976 | 1 other review | not stated | not extracted yet |
| Ansarin 2021 Survival Outcomes in Oral Tongue Cancer: A Mono-Institutional Experience Focusing on Age. PMID:33912446 | 2021 | 1 other review | not stated | not extracted yet |
| Bobdey 2017 Role of Monocyte Count and Neutrophil-to-Lymphocyte Ratio in Survival of Oral Cancer Patients. PMID:28050203 | 2017 | 1 other review | not stated | not extracted yet |
| Hasegawa 2020 Neutrophil-lymphocyte ratio associated with poor prognosis in oral cancer: a retrospective study. PMID:32552873 | 2020 | 1 other review | not stated | not extracted yet |
| Huang 2023 [Nucléoside diphosphate kinase d'érythrocytes de boeuf. Caractéristiques cinétiques]. PMID:202338 | 1977 | 1 other review | not stated | not extracted yet |
| Jariod-Ferrer 2019 Role of brain norepinephrine in neuroleptic-induced catalepsy in rats. PMID:201939 | 1977 | 1 other review | not stated | not extracted yet |
| Lee 2020 Modes of action of antimicrobial agents. PMID:202040 | 1977 | 1 other review | not stated | not extracted yet |
| Lee 2020 Prognostic value of systemic inflammatory markers for oral cancer patients based on the 8th edition of AJCC staging system. PMID:32694586 | 2020 | 1 other review | not stated | not extracted yet |
| Park 2017 Count of platelet and mean platelet volume score: serologic prognostic factor in patients with oral squamous cell carcinoma. PMID:29142864 | 2017 | 1 other review | not stated | not extracted yet |
| Ruiz-Ranz 2022 Prognostic implications of preoperative systemic inflammatory markers in oral squamous cell carcinoma, and correlations with the local… PMID:35958590 | 2022 | 1 other review | not stated | not extracted yet |
| Sun 2020 The relationship between hepatitis B virus infection and hepatic cell carcinoma in Mozambique. PMID:202048 | 1977 | 1 other review | not stated | not extracted yet |
| Sun 2020 Inflammatory Marker Predicts Outcome of Oral Squamous Cell Carcinoma Receiving Chemo-Radiotherapy. PMID:33293860 | 2020 | 1 other review | not stated | not extracted yet |
| Supanimitjaroenporn 2022 Effect of buffer composition on binding of adenosine 3':5'-cyclic monophosphate by bovine adrenal extracts. PMID:202249 | 1977 | 1 other review | not stated | not extracted yet |
| Trevisani 2023 [Electrophoretic study of the nuclear membrane ribonucleases of rat liver and hepatoma-27 cells]. PMID:202350 | 1977 | 1 other review | not stated | not extracted yet |
| Trevisani 2023 Prognostic Value of Hematological Parameters in Oral Squamous Cell Carcinoma. PMID:37958419 | 2023 | 1 other review | not stated | not extracted yet |
| Tsai 2022 Prognostic Role of High-Sensitivity Modified Glasgow Prognostic Score for Patients With Operated Oral Cavity Cancer: A Retrospective Study. PMID:35242712 | 2022 | 1 other review | not stated | not extracted yet |
| Watabe 2021 A preoperative prognostic nutritional index is a prognostic indicator in oral squamous cell carcinoma patients undergoing radical surgery. PMID:33663900 | 2021 | 1 other review | not stated | not extracted yet |
| Wu 2017 Quantitative structure-activity relationships in centrally acting imidazolidines structurally related to clonidine. PMID:201756 | 1977 | 1 other review | not stated | not extracted yet |
| Wu 2017 Prognosis of neutrophil-to-lymphocyte ratio in clinical early-stage tongue (cT1/T2N0) cancer. PMID:28831266 | 2017 | 1 other review | not stated | not extracted yet |
| Zubair 2022 Systemic inflammatory response in predicting outcomes of patients undergoing curative resection for oral squamous cell carcinoma. PMID:35248409 | 2022 | 1 other review | not stated | not extracted yet |
| Battista 2024 From Tumor Macroenvironment to Tumor Microenvironment: The Prognostic Role of the Immune System in Oral and Lung Squamous Cell Carcinoma. PMID:39123486 | 2024 | this review only | not stated | not extracted yet |
| Bobdey 2017 Therapeutic embolisation of the external carotid arterial tree. PMID:201731 | 1977 | this review only | not stated | not extracted yet |
| Chen 2019 The glandular fever syndrome revisited. PMID:201932 | 1977 | this review only | not stated | not extracted yet |
| Chen 2019 Three prognostic indexes as predictors of response to adjuvant chemoradiotherapy in patients with oral squamous cell carcinoma after… PMID:30552843 | 2019 | this review only | not stated | not extracted yet |
| Chen 2021 Prognostic value of preoperative lymphocyte-to-monocyte ratio in oral cancer patients and establishment of a dynamic nomogram. PMID:32881142 | 2021 | this review only | not stated | not extracted yet |
| Cheng 2025 Cellular immune responsiveness of breast cancer patients to Parsi human milk particles & mammary tumor virus: lymphocyte blastogenesis. PMID:202562 | 1977 | this review only | not stated | not extracted yet |
| Cheng 2025 The comparison of the prognostic value of different inflammation-related indicators in patients with oral squamous cell carcinoma. PMID:40901675 | 2025 | this review only | not stated | not extracted yet |
| Diao 2018 Adenosine 3':5'-cyclic AMP in fibroblasts from patients with cystic fibrosis and its relationship to secretion. PMID:201834 | 1976 | this review only | not stated | not extracted yet |
| Diao 2018 Preoperative systemic immune-inflammation index predicts prognosis of patients with oral squamous cell carcinoma after curative resection. PMID:30563540 | 2018 | this review only | not stated | not extracted yet |
| Ding 2021 Vasopressin test: diagnostic inaccuracy in evaluation of hypothalamic-pituitary-adrenocortical axis. PMID:202135 | 1978 | this review only | not stated | not extracted yet |
| Ding 2021 The Ratio of Preoperative Serum Biomarkers Predicts Prognosis in Patients With Oral Squamous Cell Carcinoma. PMID:34552873 | 2021 | this review only | not stated | not extracted yet |
| Furukawa 2019 Prognostic Significance of Pretreatment Lymphocyte-to-Monocyte Ratio in Patients with Tongue Cancer. PMID:30591487 | 2019 | this review only | not stated | not extracted yet |
| Hasegawa 2020 False positive complement fixation tests with respiratory virus preparations in bird fanciers with allergic alveolitis. PMID:202037 | 1977 | this review only | not stated | not extracted yet |
| Huang 2023 Association of Neutrophil-to-Lymphocyte Ratio and Bloodstream Infections with Survival after Curative-Intent Treatment in Elderly Patients… PMID:36766596 | 2023 | this review only | not stated | not extracted yet |
| Jariod-Ferrer 2019 Are Comorbidities Associated With Overall Survival in Patients With Oral Squamous Cell Carcinoma? PMID:30980811 | 2019 | this review only | not stated | not extracted yet |
| Li 2025 Effects of compounds used for radiostrontium removal on 85Sr distribution in diffusible & non-diffusible forms in rat tissues. PMID:202563 | 1977 | this review only | not stated | not extracted yet |
| Li 2025 Prognostic significance of peripheral blood inflammatory biomarkers (SII, PLR, NLR, LMR, SIRI, PIV, PNI) in lip cancer: NLR as an… PMID:41195264 | 2025 | this review only | not stated | not extracted yet |
| Lin 2021 Selective and non-selective beta-blockade in renin release. PMID:202141 | 1977 | this review only | not stated | not extracted yet |
| Lin 2021 Nomogram based on clinical characteristics and serological inflammation markers to predict overall survival of oral tongue squamous cell… PMID:34961504 | 2021 | this review only | not stated | not extracted yet |
| Nakashima 2016 Production of a non-immunoglobulin thyroid stimulator by human lymphocytes during mixed culture with human thyroid cells. PMID:201642 | 1978 | this review only | not stated | not extracted yet |
| Nakashima 2016 Pre-treatment neutrophil to lymphocyte ratio predicts the chemoradiotherapy outcome and survival in patients with oral squamous cell… PMID:26812901 | 2016 | this review only | not stated | not extracted yet |
| Nie 2021 Limbic system regulation of ACTH. PMID:202143 | 1977 | this review only | not stated | not extracted yet |
| Nie 2021 Nomograms to predict the prognosis in locally advanced oral squamous cell carcinoma after curative resection. PMID:33827452 | 2021 | this review only | not stated | not extracted yet |
| Ohyama 2024 [Surgical or conservative therapy in peripheral nerve injuries?]. PMID:202444 | 1978 | this review only | not stated | not extracted yet |
| Ohyama 2024 CT-assessed sarcopenia and prognostic nutritional index are associated with poor prognosis in oral squamous cell carcinoma. PMID:37935816 | 2024 | this review only | not stated | not extracted yet |
| Park 2017 The effect of pancuronium and gallamine on muscarinic transmission in the superior cervical ganglion. PMID:201745 | 1978 | this review only | not stated | not extracted yet |
| Ruiz-Ranz 2022 Changes in pulmonary surfactant and phosphatidylcholine metabolism in rats exposed to chrysotile asbestos dust. PMID:202246 | 1977 | this review only | not stated | not extracted yet |
| Sano 2018 Nuclear localisation of an oocyte component required for the stability of injected DNA. PMID:201847 | 1977 | this review only | not stated | not extracted yet |
| Supanimitjaroenporn 2022 Prognostic value of pretreatment lymphocyte-to-monocyte ratio in patients with advanced oral cavity cancer. PMID:35734053 | 2022 | this review only | not stated | not extracted yet |
| Tsai 2021 Liquoid-induced arterial lesions and the generalized Shartzman reaction. PMID:202152 | 1977 | this review only | not stated | not extracted yet |
| Tsai 2021 Advanced Lung Cancer Inflammation Index Predicts Survival Outcomes of Patients With Oral Cavity Cancer Following Curative Surgery. PMID:34660250 | 2021 | this review only | not stated | not extracted yet |
| Tsai 2022 The effect of bovine tendon glycoprotein on the formation of fibrils from collagen solutions. PMID:202251 | 1977 | this review only | not stated | not extracted yet |
| Wang 2021 The sequence of events in the development of bilateral renal cortical necrosis accompanying the generalized Shwartzman reaction. PMID:202153 | 1977 | this review only | not stated | not extracted yet |
| Wang 2021 Retrospective study on the potential of albumin/globulin ratio as a prognostic biomarker for oral cavity cancer patients. PMID:32583177 | 2021 | this review only | not stated | not extracted yet |
| Watabe 2021 Ether-dissolved ethiodol for lymphangiography: an experimental study. PMID:202154 | 1977 | this review only | not stated | not extracted yet |
| Wei 2021 Computed tomography in the evaluation of sarcomatous tumors of the thigh. PMID:202155 | 1978 | this review only | not stated | not extracted yet |
| Wei 2021 A Prognostic Model Based on Clinicopathological Features and Inflammation- and Nutrition-Related Indicators Predicts Overall Survival in… PMID:34866500 | 2021 | this review only | not stated | not extracted yet |
| Wu 2021 Comparative prognostic value of different preoperative complete blood count cell ratios in patients with oral cavity cancer treated with… PMID:33624454 | 2021 | this review only | not stated | not extracted yet |
| Wu 2023 Nomogram incorporating potent inflammatory indicators for overall survival estimation of patients with primary oral squamous cell carcinoma. PMID:37519800 | 2023 | this review only | not stated | not extracted yet |
| Zakaria 2022 Relationship between the reduction of oxygen, artificial acceptors and cytochrome P-450 by NADPH--cytochrome c reductase. PMID:202259 | 1977 | this review only | not stated | not extracted yet |
| Zakaria 2022 Prognostic Abilities of Pre- and Post-Treatment Inflammatory Markers in Oral Squamous Cell Carcinoma: Stepwise Modelling. PMID:36295584 | 2022 | this review only | not stated | not extracted yet |
| Zhou 2022 The effect of chronic diabetes, induced by streptozotocin, on the activities of some enzymes of glycerolipid synthesis in rat liver. PMID:202260 | 1977 | this review only | not stated | not extracted yet |
| Zhou 2022 A novel clinical signature predicts the survival of elderly patients with oral squamous cell carcinoma. PMID:33783598 | 2022 | this review only | not stated | not extracted yet |
| Zubair 2022 Rapid isolation of plasma membranes in high yield from cultured fibroblasts. PMID:202261 | 1977 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients with histopathologically confirmed oral squamous cell carcinoma | Patients with OSCC (n=12,225; 35 studies) |
| Intervention | High pretreatment NLR, PLR or LMR with a specified cut-off | High pretreatment NLR (OS n=19 studies; DFS n=11), PLR (OS n=11; DFS n=4), LMR (OS n=10; DFS n=2) |
| Comparison | Low pretreatment NLR, PLR or LMR | Low pretreatment NLR, PLR or LMR |
| Outcomes | Overall survival and disease-free survival (hazard ratios from multivariate Cox regression); restricted mean survival time | Overall survival; disease-free survival; restricted mean survival time difference for NLR (n=3 studies each) |
| Study designs | Retrospective or prospective cohort studies with NOS score >= 6 | 35 retrospective cohort studies |
| Timing | Pretreatment blood markers; survival follow-up | Pretreatment (preoperative) blood counts |