Non-Cochrane · prognostic · PM42930529
Prognostic Value and Stage/Nodal Correlates of Serum and Salivary CRP, CYFRA 21-1, and SCC-Ag Biomarkers in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.
Qadir Balen Hamid, Mahmood Mohammed Khalid, Mohammed Ameen Hazha Abdulla, et al. · Medical sciences (Basel, Switzerland) · 2026 · PubMed · doi:10.3390/medsci14060610
Findings
Population Adults with histopathologically confirmed oral squamous cell carcinoma
4 findings
| Serum SCC-Ag alone, elevated | Normal serum SCC-Ag | Overall survival | HR 1.43 [0.09, 23.14] Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness 2 studies |
| Serum CRP alone, elevated | Normal serum CRP | Overall survival | HR 1.33 [0.89, 1.99] Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness 5 studies |
| Serum CYFRA 21-1 alone, elevated | Normal serum CYFRA 21-1 | Disease-free survival | HR 1.61 [0.39, 6.61] Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness 2 studies |
| Salivary CYFRA 21-1 concentration in patients with recurrence | Salivary CYFRA 21-1 concentration in patients without recurrence | Recurrence | SMD 0.80 [0.04, 1.55] Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness 2 studies · 74 participants |
Included primary studies 28
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Fang 2013 Refining the role of preoperative C-reactive protein by neutrophil/lymphocyte ratio in oral cavity squamous cell carcinoma. PMID:23619955 | 2013 | 1 other review | not stated | not extracted yet |
| Graupp 2018 C-reactive protein is an independent prognostic marker in patients with tongue carcinoma - A retrospective study. PMID:29575651 | 2018 | 1 other review | Overall survival | not extracted yet |
| Park 2017 Count of platelet and mean platelet volume score: serologic prognostic factor in patients with oral squamous cell carcinoma. PMID:29142864 | 2017 | 1 other review | Overall survival | not extracted yet |
| Tsai 2023 A Nomogram Incorporating Neutrophil-to-Lymphocyte Ratio and Squamous Cell Carcinoma Antigen Predicts the Prognosis of Oral Cancers. PMID:37173956 | 2023 | 1 other review | Overall survival | not extracted yet |
| Acharya 2018 Clinical significance of preoperative serum C-reactive protein in oral squamous cell carcinoma. PMID:28716471 | 2018 | this review only | not stated | not extracted yet |
| Adel 2016 Preoperative SCC Antigen, CRP Serum Levels, and Lymph Node Density in Oral Squamous Cell Carcinoma. PMID:27057838 | 2016 | this review only | not stated | not extracted yet |
| Blatt 2018 Hemoglobin, C-reactive protein and ferritin in patients with oral carcinoma and their clinical significance - A prospective clinical study. PMID:29287926 | 2018 | this review only | not stated | not extracted yet |
| Chen 2011 Preoperative circulating C-reactive protein levels predict pathological aggressiveness in oral squamous cell carcinoma: a retrospective… PMID:21332670 | 2011 | this review only | not stated | not extracted yet |
| Chen 2014 Using SCC antigen and CRP levels as prognostic biomarkers in recurrent oral cavity squamous cell carcinoma. PMID:25061977 | 2014 | this review only | not stated | not extracted yet |
| De Paz 2019 Prognostic Roles of SCC Antigen, CRP and CYFRA 21-1 in Oral Cavity Squamous Cell Carcinoma. PMID:30952746 | 2019 | this review only | Disease-free survival | not extracted yet |
| Ge 2018 Elevated red blood cell distribution width predicts poor prognosis in patients with oral squamous cell carcinoma. PMID:30271209 | 2018 | this review only | Overall survival | not extracted yet |
| Hsu 2015 Serum markers of CYFRA 21-1 and C-reactive proteins in oral squamous cell carcinoma. PMID:26292957 | 2015 | this review only | Disease-free survival | not extracted yet |
| Huang 2012 Risk stratification in oral cavity squamous cell carcinoma by preoperative CRP and SCC antigen levels. PMID:22576068 | 2012 | this review only | not stated | not extracted yet |
| Imai 2015 Prognostic significance of serum squamous cell carcinoma antigen in patients with head and neck cancer. PMID:25622661 | 2015 | this review only | Overall survival | not extracted yet |
| Ito 2023 Prognostic impact of preoperative Geriatric Nutritional Risk Index in oral squamous cell carcinoma. PMID:35582815 | 2023 | this review only | Overall survival | not extracted yet |
| Jablonska 1997 Serum Levels of IL-1b, IL-6, TNF-a, sTNF-RI and CRP in Patients with Oral Cavity Cancer. PMID:11173639 | 1997 | this review only | not stated | not extracted yet |
| Khandavilli 2009 Serum C-reactive protein as a prognostic indicator in patients with oral squamous cell carcinoma. PMID:19502100 | 2009 | this review only | not stated | not extracted yet |
| Krimmel 1998 Relevance of SCC-Ag, CEA, CA 19.9 and CA 125 for diagnosis and follow-up in oral cancer. PMID:9777503 | 1998 | this review only | not stated | not extracted yet |
| Kruse 2010 C-reactive protein levels: a prognostic marker for patients with head and neck cancer? PMID:20673375 | 2010 | this review only | not stated | not extracted yet |
| Lin 2011 Clinical significance of preoperative squamous cell carcinoma antigen in oral-cavity squamous cell carcinoma. PMID:21520110 | 2011 | this review only | not stated | not extracted yet |
| Malhotra 2016 Correlation of Cyfra 21-1 levels in saliva and serum with CK19 mRNA expression in oral squamous cell carcinoma. PMID:26779624 | 2016 | this review only | Recurrence | not extracted yet |
| Metgud 2016 Altered serum and salivary C-reactive protein levels in patients with oral premalignant lesions and oral squamous cell carcinoma. PMID:26529498 | 2016 | this review only | not stated | not extracted yet |
| Nagumo 1990 Squamous cell carcinoma antigen in oral squamous cell carcinomas. PMID:2225283 | 1990 | this review only | not stated | not extracted yet |
| Singhavi 2021 Impact of pre-operative serum C-reactive protein and cell-free chromatin levels on tumor aggressiveness and survival outcome in oral… PMID:33183996 | 2021 | this review only | not stated | not extracted yet |
| Stamatoski 2026 Baseline and treatment-induced change of salivary CYFRA 21 - 1 as independent predictors of recurrence in oral squamous cell carcinoma. PMID:42249204 | 2026 | this review only | not stated | not extracted yet |
| Tai 2017 Roles of preoperative C-reactive protein are more relevant in buccal cancer than other subsites. PMID:28209200 | 2017 | this review only | not stated | not extracted yet |
| Yamagata 2020 The Association between D-Dimer and Prognosis in the Patients with Oral Cancer. PMID:32756384 | 2020 | this review only | Overall survival | not extracted yet |
| Zhong 2007 Increased Cyfra 21-1 concentration in saliva from primary oral squamous cell carcinoma patients. PMID:17612501 | 2007 | this review only | Recurrence | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults with histopathologically confirmed oral cavity squamous cell carcinoma | Patients with OSCC (28 studies: 21 quantitative, 7 narrative; individual samples 20 to 343; approximately 3496 participants with registry overlap) |
| Intervention | Serum and/or salivary CYFRA 21-1, SCC-Ag and/or CRP status, alone or combined (elevated or continuous) | Serum SCC-Ag alone (n=2 pooled, OS); serum CRP alone (n=5 pooled, OS); serum CYFRA 21-1 alone (n=2 pooled, DFS); salivary CYFRA 21-1 (n=2 pooled, recurrence); non-pooled composite SCC-Ag+CRP and CRP-alone registry models |
| Comparison | Normal versus elevated or continuous marker status | Normal/low marker levels; patients without recurrence (salivary CYFRA 21-1 SMD) |
| Outcomes | Recurrence, disease-free survival, overall survival; secondary descriptive associations with stage, grade or metastasis | Overall survival (n=7 pooled across two pools); disease-free survival (n=2 pooled); recurrence (n=2 pooled SMD); stage/grade/nodal correlates (narrative, n=7) |
| Study designs | Cohort, cross-sectional or trial designs | 20 retrospective cohorts, 4 prospective cohorts, 4 cross-sectional studies |
| Timing | Marker assessed at or near diagnosis; unrestricted follow-up | Preoperative/baseline marker measurement; follow-up not restricted |