Non-Cochrane · prognostic · PM41467693
Prognostic Significance of the Pretreatment Neutrophil-to-Lymphocyte Ratio and Tumor-Associated Neutrophils in Head and Neck Squamous Cell Carcinoma: Systematic Review and Meta-Analysis.
Ratnayake Ahana Kapuge Dona Varuni Yashodha, Hyytiäinen Aini, Gkountana Georgia Vasiliki, et al. · Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026 · PubMed · doi:10.1111/jop.70110
Findings
24 findings
| Population | ||||
|---|---|---|---|---|
| Patients with HNSCC confirmed by histopathology | High pretreatment peripheral blood NLR | Low pretreatment NLR (below cutoff) | Disease-free survival Univariate analysis | HR 1.85 [1.55, 2.20] GRADE not reported 23 studies · 4753 participants |
| Patients with HNSCC confirmed by histopathology | High pretreatment peripheral blood NLR | Low pretreatment NLR (below cutoff) | Recurrence-free survival Multivariate analysis | HR 1.33 [1.15, 1.55] GRADE not reported 5 studies · 1453 participants |
| Patients with HNSCC confirmed by histopathology | High pretreatment peripheral blood NLR | Low pretreatment NLR (below cutoff) | Progression-free survival Univariate analysis | HR 1.95 [1.48, 2.56] GRADE not reported 14 studies · 2704 participants |
| Patients with HNSCC confirmed by histopathology | High pretreatment peripheral blood NLR | Low pretreatment NLR (below cutoff) | Disease-specific survival Univariate analysis | HR 2.16 [1.58, 2.96] GRADE not reported 9 studies · 2192 participants |
| Patients with HNSCC confirmed by histopathology | High pretreatment peripheral blood NLR | Low pretreatment NLR (below cutoff) | Disease-free survival Multivariate analysis | HR 1.75 [1.46, 2.10] GRADE not reported 16 studies · 3836 participants |
| Patients with HNSCC confirmed by histopathology | High pretreatment peripheral blood NLR | Low pretreatment NLR (below cutoff) | Recurrence-free survival Univariate analysis | HR 1.11 [1.05, 1.18] GRADE not reported 6 studies · 1643 participants |
| Patients with HNSCC confirmed by histopathology | High pretreatment peripheral blood NLR | Low pretreatment NLR (below cutoff) | Overall survival Multivariate analysis | HR 1.70 [1.56, 1.86] GRADE not reported 76 studies · 20576 participants |
| Patients with HNSCC confirmed by histopathology | High pretreatment peripheral blood NLR | Low pretreatment NLR (below cutoff) | Disease-specific survival Multivariate analysis | HR 2.06 [1.72, 2.47] GRADE not reported 9 studies · 1733 participants |
| Patients with HNSCC confirmed by histopathology | High pretreatment peripheral blood NLR | Low pretreatment NLR (below cutoff) | Overall survival Univariate analysis | HR 1.88 [1.72, 2.06] GRADE not reported 67 studies · 16786 participants |
| Patients with HNSCC confirmed by histopathology | High pretreatment peripheral blood NLR | Low pretreatment NLR (below cutoff) | Progression-free survival Multivariate analysis | HR 1.93 [1.63, 2.29] GRADE not reported 21 studies · 5764 participants |
| Patients with sinonasal squamous cell carcinoma | High pretreatment peripheral blood NLR | Low pretreatment NLR (below cutoff) | Overall survival Tumor site: SNSCC | HR 3.05 [0.82, 11.33] GRADE not reported 2 studies · 188 participants |
| Patients with oropharyngeal squamous cell carcinoma | High pretreatment peripheral blood NLR | Low pretreatment NLR (below cutoff) | Overall survival Tumor site: OPSCC | HR 2.52 [1.63, 3.90] GRADE not reported 4 studies · 712 participants |
| Patients with nasopharyngeal carcinoma | High pretreatment peripheral blood NLR | Low pretreatment NLR (below cutoff) | Overall survival Tumor site: NPC | HR 2.16 [1.70, 2.73] GRADE not reported 7 studies · 1554 participants |
| Patients with oral squamous cell carcinoma | High pretreatment peripheral blood NLR | Low pretreatment NLR (below cutoff) | Overall survival Tumor site: OSCC | HR 2.07 [1.65, 2.61] GRADE not reported 15 studies · 5669 participants |
| Patients with oral tongue squamous cell carcinoma | High pretreatment peripheral blood NLR | Low pretreatment NLR (below cutoff) | Overall survival Tumor site: OTSCC | HR 1.95 [1.37, 2.77] GRADE not reported 5 studies · 749 participants |
| Patients with laryngeal squamous cell carcinoma | High pretreatment peripheral blood NLR | Low pretreatment NLR (below cutoff) | Overall survival Tumor site: LSCC | HR 1.77 [1.14, 2.74] GRADE not reported 9 studies · 2481 participants |
| Patients with hypopharyngeal squamous cell carcinoma | High pretreatment peripheral blood NLR | Low pretreatment NLR (below cutoff) | Overall survival Tumor site: HPSCC | HR 1.62 [1.13, 2.32] GRADE not reported 8 studies · 915 participants |
| Patients with head and neck squamous cell carcinoma (site not specified) | High pretreatment peripheral blood NLR | Low pretreatment NLR (below cutoff) | Overall survival Tumor site: HNSCC | HR 1.54 [1.37, 1.74] GRADE not reported 17 studies · 4518 participants |
| Patients with HNSCC confirmed by histopathology | High pretreatment NLR (cutoff 1 to 1.99) | Low NLR (below cutoff 1 to 1.99) | Overall survival NLR cutoff category: 1 to 1.99 | HR 1.83 [1.25, 2.68] GRADE not reported 9 studies · 1214 participants |
| Patients with HNSCC confirmed by histopathology | High pretreatment NLR (cutoff 2 to 2.99) | Low NLR (below cutoff 2 to 2.99) | Overall survival NLR cutoff category: 2 to 2.99 | HR 1.79 [1.50, 2.14] GRADE not reported 26 studies · 6812 participants |
| Patients with HNSCC confirmed by histopathology | High pretreatment NLR (cutoff 3 to 3.99) | Low NLR (below cutoff 3 to 3.99) | Overall survival NLR cutoff category: 3 to 3.99 | HR 1.77 [1.52, 2.07] GRADE not reported 18 studies · 5257 participants |
| Patients with HNSCC confirmed by histopathology | High pretreatment NLR (cutoff 4 to 4.99) | Low NLR (below cutoff 4 to 4.99) | Overall survival NLR cutoff category: 4 to 4.99 | HR 2.35 [1.71, 3.23] GRADE not reported 9 studies · 1893 participants |
| Patients with HNSCC confirmed by histopathology | High pretreatment NLR (cutoff 5 to 5.99) | Low NLR (below cutoff 5 to 5.99) | Overall survival NLR cutoff category: 5 to 5.99 | HR 2.44 [1.92, 3.12] GRADE not reported 3 studies · 1044 participants |
| Patients with HNSCC confirmed by histopathology | High pretreatment NLR (cutoff above 6) | Low NLR (below cutoff above 6) | Overall survival NLR cutoff category: above 6 | HR 2.19 [1.40, 3.42] GRADE not reported 2 studies · 359 participants |
Included primary studies 111
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Sano 2018 Correlation of Inflammatory Markers, Survival, and COX2 Expression in Oral Cancer and Implications for Prognosis. PMID:29359615 | 2018 | 2 other reviews | not stated | not extracted yet |
| Ansarin 2021 Survival Outcomes in Oral Tongue Cancer: A Mono-Institutional Experience Focusing on Age. PMID:33912446 | 2021 | 1 other review | not stated | not extracted yet |
| Bobdey 2017 Role of Monocyte Count and Neutrophil-to-Lymphocyte Ratio in Survival of Oral Cancer Patients. PMID:28050203 | 2017 | 1 other review | not stated | not extracted yet |
| Fang 2013 Refining the role of preoperative C-reactive protein by neutrophil/lymphocyte ratio in oral cavity squamous cell carcinoma. PMID:23619955 | 2013 | 1 other review | not stated | not extracted yet |
| Graupp 2018 C-reactive protein is an independent prognostic marker in patients with tongue carcinoma - A retrospective study. PMID:29575651 | 2018 | 1 other review | not stated | not extracted yet |
| Hasegawa 2020 Neutrophil-lymphocyte ratio associated with poor prognosis in oral cancer: a retrospective study. PMID:32552873 | 2020 | 1 other review | not stated | not extracted yet |
| Lee 2020 Prognostic value of systemic inflammatory markers for oral cancer patients based on the 8th edition of AJCC staging system. PMID:32694586 | 2020 | 1 other review | not stated | not extracted yet |
| Ruiz-Ranz 2022 Prognostic implications of preoperative systemic inflammatory markers in oral squamous cell carcinoma, and correlations with the local… PMID:35958590 | 2022 | 1 other review | not stated | not extracted yet |
| Sun 2020 Inflammatory Marker Predicts Outcome of Oral Squamous Cell Carcinoma Receiving Chemo-Radiotherapy. PMID:33293860 | 2020 | 1 other review | not stated | not extracted yet |
| Trevisani 2023 Prognostic Value of Hematological Parameters in Oral Squamous Cell Carcinoma. PMID:37958419 | 2023 | 1 other review | not stated | not extracted yet |
| Tsai 2022 Prognostic Role of High-Sensitivity Modified Glasgow Prognostic Score for Patients With Operated Oral Cavity Cancer: A Retrospective Study. PMID:35242712 | 2022 | 1 other review | not stated | not extracted yet |
| Tsai 2023 A Nomogram Incorporating Neutrophil-to-Lymphocyte Ratio and Squamous Cell Carcinoma Antigen Predicts the Prognosis of Oral Cancers. PMID:37173956 | 2023 | 1 other review | not stated | not extracted yet |
| Watabe 2021 A preoperative prognostic nutritional index is a prognostic indicator in oral squamous cell carcinoma patients undergoing radical surgery. PMID:33663900 | 2021 | 1 other review | not stated | not extracted yet |
| Wu 2017 Prognosis of neutrophil-to-lymphocyte ratio in clinical early-stage tongue (cT1/T2N0) cancer. PMID:28831266 | 2017 | 1 other review | not stated | not extracted yet |
| Zubair 2022 Systemic inflammatory response in predicting outcomes of patients undergoing curative resection for oral squamous cell carcinoma. PMID:35248409 | 2022 | 1 other review | not stated | not extracted yet |
| Al-Rajhi 2021 Prognostic markers compared to CD3+TIL in locally advanced nasopharyngeal carcinoma. PMID:34797353 | 2021 | this review only | not stated | not extracted yet |
| An 2011 Elevated neutrophil to lymphocyte ratio predicts poor prognosis in nasopharyngeal carcinoma. PMID:21052888 | 2011 | this review only | not stated | not extracted yet |
| Brewczyński 2021 Comparison of Selected Immune and Hematological Parameters and Their Impact on Survival in Patients with HPV-Related and HPV-Unrelated… PMID:34209764 | 2021 | this review only | not stated | not extracted yet |
| Brkic 2020 Impact of pretherapeutic neutrophil-to-lymphocyte ratio, serum albumin, body-mass index, and advanced lung cancer inflammation index on… PMID:31810849 | 2020 | this review only | not stated | not extracted yet |
| Brunkhorst 2024 Neutrophils in HNSCC Can Be Associated with Both a Worse or Favorable Prognosis. PMID:38397442 | 2024 | this review only | not stated | not extracted yet |
| Cai 2021 The Prognostic Value of Preoperative Plasma Fibrinogen and Neutrophil-to-Lymphocyte Ratio in Patients With Laryngeal Squamous Cell… PMID:32380854 | 2021 | this review only | not stated | not extracted yet |
| Caldeira 2015 Differential infiltration of neutrophils in T1-T2 versus T3-T4 oral squamous cell carcinomas: a preliminary study. PMID:26467671 | 2015 | this review only | not stated | not extracted yet |
| Charles 2016 PMID:126892430 | NR | this review only | not stated | not extracted yet |
| Charles 2016 Systemic inflammation is an independent predictive marker of clinical outcomes in mucosal squamous cell carcinoma of the head and neck in… PMID:26892430 | 2016 | this review only | not stated | not extracted yet |
| Chen 2018 Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous… PMID:30103707 | 2018 | this review only | not stated | not extracted yet |
| Chen 2018 Predictive Value of the Pretreatment Neutrophil-to-Lymphocyte Ratio in Head and Neck Squamous Cell Carcinoma. PMID:30241364 | 2018 | this review only | not stated | not extracted yet |
| Cho 2018 The Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Head and Neck Cancer Patients Treated with Radiotherapy. PMID:30513928 | 2018 | this review only | not stated | not extracted yet |
| Cho 2022 Prognostic Role of Systemic Inflammatory Markers in Patients Undergoing Surgical Resection for Oral Squamous Cell Carcinoma. PMID:35740290 | 2022 | this review only | not stated | not extracted yet |
| Cho 2022 PMID:435740290 | NR | this review only | not stated | not extracted yet |
| Chua 2016 Neutrophil-to-lymphocyte ratio as a prognostic marker in locally advanced nasopharyngeal carcinoma: A pooled analysis of two randomised… PMID:27640138 | 2016 | this review only | not stated | not extracted yet |
| de Almeida 2019 Postoperative wound infections, neutrophil-to-lymphocyte ratio, and cancer recurrence in patients with oral cavity cancer undergoing… PMID:31421467 | 2019 | this review only | not stated | not extracted yet |
| Du 2018 Pre-treatment neutrophil-to-lymphocyte ratio predicts survival in patients with laryngeal cancer. PMID:29399193 | 2018 | this review only | not stated | not extracted yet |
| Eskiizmir 2019 The evaluation of pretreatment neutrophil-lymphocyte ratio and derived neutrophil-lymphocyte ratio in patients with laryngeal neoplasms. PMID:29936214 | 2019 | this review only | not stated | not extracted yet |
| Fanetti 2020 Prognostic significance of neutrophil-to-lymphocyte ratio in HPV status era for oropharyngeal cancer. PMID:32315470 | 2020 | this review only | not stated | not extracted yet |
| Fu 2016 Preoperative Neutrophil-to-lymphocyte Ratio Predicts Long-term Survival in Patients Undergoing Total Laryngectomy With Advanced Laryngeal… PMID:26871799 | 2016 | this review only | not stated | not extracted yet |
| Go 2024 Discrete prognostic implication of sarcopenia according to nutritional status in surgically treated patients with hypopharyngeal cancer. PMID:38866697 | 2024 | this review only | not stated | not extracted yet |
| Gorphe 2018 Anemia and neutrophil-to-lymphocyte ratio are prognostic in p16-positive oropharyngeal carcinoma treated with concurrent chemoradiation. PMID:29253748 | 2018 | this review only | not stated | not extracted yet |
| Gundog 2020 The prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in nasopharyngeal cancer. PMID:32277656 | 2020 | this review only | not stated | not extracted yet |
| Haring 2023 Patterns of recurrence in head and neck squamous cell carcinoma to inform personalized surveillance protocols. PMID:37162461 | 2023 | this review only | not stated | not extracted yet |
| Hasegawa 2020 PMID:332552873 | NR | this review only | not stated | not extracted yet |
| Homa-Mlak 2021 Neutrophil-to-Lymphocyte Ratio as a Factor Predicting Radiotherapy Induced Oral Mucositis in Head Neck Cancer Patients Treated with… PMID:34640462 | 2021 | this review only | not stated | not extracted yet |
| Ikeguchi 2016 Glasgow prognostic score and neutrophil-lymphocyte ratio are good prognostic indicators after radical neck dissection for advanced… PMID:27236289 | 2016 | this review only | not stated | not extracted yet |
| Iuchi 2020 Impacts of Inflammation-Based Prognostic Scores on Survival in Patients With Hypopharyngeal Squamous Cell Carcinoma. PMID:33447693 | 2020 | this review only | not stated | not extracted yet |
| Iuchi 2020 PMID:833447693 | NR | this review only | not stated | not extracted yet |
| Jin 2015 Pretreatment neutrophil-to-lymphocyte ratio as predictor of survival for patients with metastatic nasopharyngeal carcinoma. PMID:24327524 | 2015 | this review only | not stated | not extracted yet |
| Juesas Iglesias 2024 Prognostic value of preoperative inflammatory ratios in early glottic cancer treated with transoral laser surgery. PMID:38196290 | 2024 | this review only | not stated | not extracted yet |
| Kano 2017 Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for head and neck cancer. PMID:27617428 | 2017 | this review only | not stated | not extracted yet |
| Kao 2018 Nomogram based on albumin and neutrophil-to-lymphocyte ratio for predicting the prognosis of patients with oral cavity squamous cell… PMID:30166572 | 2018 | this review only | not stated | not extracted yet |
| Kasahara 2024 Pretreatment neutrophil-lymphocyte ratio as a prognostic factor in recurrent/metastatic head and neck cancer treated with pembrolizumab. PMID:39548176 | 2024 | this review only | not stated | not extracted yet |
| Kawano 2024 Prognostic value of pretreatment inflammatory biomarkers in patients with laryngeal cancer. PMID:38311505 | 2024 | this review only | not stated | not extracted yet |
| Kaźmierska 2023 Significance of neutrophil to lymphocyte ratio as a predictor of outcome in head and neck cancer treated with definitive chemoradiation. PMID:37795402 | 2023 | this review only | not stated | not extracted yet |
| Khazravi 2022 Prognostic Value of Lymph Node Density Compared to Pre-operative Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in… PMID:36274869 | 2022 | this review only | not stated | not extracted yet |
| Kim 2017 Prognostic value of posttreatment neutrophil-lymphocyte ratio in head and neck squamous cell carcinoma treated by chemoradiotherapy. PMID:27269133 | 2017 | this review only | not stated | not extracted yet |
| Kotha 2021 Prognostic Utility of Pretreatment Neutrophil-Lymphocyte Ratio in Advanced Larynx Cancer. PMID:34658619 | 2021 | this review only | not stated | not extracted yet |
| Kreinbrink 2021 Pre-treatment absolute lymphocyte count predicts for improved survival in human papillomavirus (HPV)-driven oropharyngeal squamous cell… PMID:33901866 | 2021 | this review only | not stated | not extracted yet |
| Kuo 2019 The Role of Pretreatment Serum Neutrophil-to-Lymphocyte Ratio in Hypopharyngeal Cancer Treated with Definitive Chemoradiotherapy: A Pilot… PMID:30733592 | 2019 | this review only | not stated | not extracted yet |
| Kuwahara 2018 Fibrinogen and Neutrophil-to-lymphocyte Ratio Predicts Survival in Patients with Advanced Hypopharyngeal Squamous Cell Carcinoma. PMID:30194184 | 2018 | this review only | not stated | not extracted yet |
| Li 2017 An inflammatory biomarker-based nomogram to predict prognosis of patients with nasopharyngeal carcinoma: an analysis of a prospective study. PMID:27860387 | 2017 | this review only | not stated | not extracted yet |
| Li 2019 Neutrophils infiltration and its correlation with human papillomavirus status in the oral squamous cell carcinoma. PMID:31239772 | 2019 | this review only | not stated | not extracted yet |
| Li 2021 Prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and systemic immune-inflammation index in patients… PMID:33321001 | 2021 | this review only | not stated | not extracted yet |
| Li 2024 Predictive value of systemic inflammatory response-related indices for survival in tongue cancer. PMID:35989554 | 2024 | this review only | not stated | not extracted yet |
| Liao 2018 Prognostic impact of pre-treatment neutrophil-to-lymphocyte ratio (NLR) in nasopharyngeal carcinoma: A retrospective study of 180… PMID:28950051 | 2018 | this review only | not stated | not extracted yet |
| Liew 2018 Neutrophil-lymphocyte ratios in the prognostication of primary non-metastatic nasopharyngeal carcinoma. PMID:29128472 | 2018 | this review only | not stated | not extracted yet |
| Liu 2020 PMID:231914029 | NR | this review only | not stated | not extracted yet |
| Liu 2020 The prognostic value of the ratio of neutrophils to lymphocytes before and after intensity modulated radiotherapy for patients with… PMID:31914029 | 2020 | this review only | not stated | not extracted yet |
| Lo 2017 The Pretreatment Neutrophil-to-Lymphocyte Ratio is a Prognostic Determinant of T3-4 Hypopharyngeal Squamous Cell Carcinoma. PMID:28432481 | 2017 | this review only | not stated | not extracted yet |
| Lu 2017 Prognostic Significance of Neutrophil to Lymphocyte Ratio, Lymphocyte to Monocyte Ratio, and Platelet to Lymphocyte Ratio in Patients with… PMID:28321405 | 2017 | this review only | not stated | not extracted yet |
| Lu 2020 Nomogram Based on Systemic Immune-Inflammation Index to Predict Survival of Tongue Cancer Patients Who Underwent Cervical Dissection. PMID:32219070 | 2020 | this review only | not stated | not extracted yet |
| Mittal 2020 Exploring the prognostic significance of the pretreatment inflammatory markers in hypopharyngeal cancers: A retrospective analysis DOI:10.4103/crst.crst_152_20 | 2020 | this review only | not stated | not extracted yet |
| Moon 2016 Prognostic value of nutritional and hematologic markers in head and neck squamous cell carcinoma treated by chemoradiotherapy. PMID:26653356 | 2016 | this review only | not stated | not extracted yet |
| Muhaxheri 2018 Multivariate analysis of preoperative and postoperative neutrophil-to-lymphocyte ratio as an indicator of head and neck squamous cell… PMID:29559186 | 2018 | this review only | not stated | not extracted yet |
| Ng 2021 Prognostic significance of pre-treatment neutrophil-to-lymphocyte ratio (NLR) in patients with oropharyngeal cancer treated with… PMID:33051590 | 2021 | this review only | not stated | not extracted yet |
| Oka 2023 Prognostic values of systemic inflammation and nutrition-based prognostic indices in oropharyngeal carcinoma. PMID:37342125 | 2023 | this review only | not stated | not extracted yet |
| Ong 2017 Low Pretreatment Lymphocyte-Monocyte Ratio and High Platelet-Lymphocyte Ratio Indicate Poor Cancer Outcome in Early Tongue Cancer. PMID:28063763 | 2017 | this review only | not stated | not extracted yet |
| Ono 2018 Pre-treatment CD8+ tumour-infiltrating lymphocyte density predicts distant metastasis after definitive treatment in patients with stage… PMID:29896922 | 2018 | this review only | not stated | not extracted yet |
| Ooyama 2025 Pretreatment nutritional indices are associated with survival and T-cell exhaustion in recurrent or metastatic oral squamous cell… PMID:39939190 | 2025 | this review only | not stated | not extracted yet |
| Park 2018 Prognostic value of circulating biomarker score in advanced-stage head and neck squamous cell carcinoma. PMID:29428866 | 2018 | this review only | not stated | not extracted yet |
| Perisanidis 2013 High neutrophil-to-lymphocyte ratio is an independent marker of poor disease-specific survival in patients with oral cancer. PMID:23292862 | 2013 | this review only | not stated | not extracted yet |
| Rey 2025 Relationship between muscular mass, inflammatory status, tumor metabolic activity and oral intake in head and neck cancer at the outset of… PMID:39880203 | 2025 | this review only | not stated | not extracted yet |
| Sheng 2019 A Retrospective Study of The Prognostic Significance of Preoperative Plasma Fibrinogen, Mean Platelet Volume, and the… PMID:31210172 | 2019 | this review only | not stated | not extracted yet |
| Sheng 2019 PMID:931210172 | NR | this review only | not stated | not extracted yet |
| Shi 2025 Pan-immune-inflammation value: a new prognostic index in operative laryngeal and pharyngeal carcinomas. PMID:38877363 | 2025 | this review only | not stated | not extracted yet |
| So 2018 Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Patients with Human Papillomavirus-Positive Oropharyngeal Cancer. PMID:29557259 | 2018 | this review only | not stated | not extracted yet |
| Song 2022 The prognostic value of before treatment neutrophil-to-lymphocyte ratio in nasopharyngeal carcinoma. PMID:34510259 | 2022 | this review only | not stated | not extracted yet |
| Song 2024 Prognostic value of 18F-FDG PET radiomics and sarcopenia in patients with oral squamous cell carcinoma. PMID:38252704 | 2024 | this review only | not stated | not extracted yet |
| Sun 2016 Pretreatment hematologic markers as prognostic factors in patients with nasopharyngeal carcinoma: Neutrophil-lymphocyte ratio and… PMID:26362911 | 2016 | this review only | not stated | not extracted yet |
| Sunkara 2025 The Prognostication of Surgically Resected Head and Neck Squamous Cell Carcinoma Using Pre-Therapy Neutrophil and Lymphocyte Counts. PMID:39415507 | 2025 | this review only | not stated | not extracted yet |
| Tazeen 2020 Assessment of Pretreatment Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in Prognosis of Oral Squamous Cell Carcinoma. PMID:32027861 | 2020 | this review only | not stated | not extracted yet |
| Tham 2019 Systemic immune response in squamous cell carcinoma of the head and neck: a comparative concordance index analysis. PMID:31312922 | 2019 | this review only | not stated | not extracted yet |
| Tomasoni 2023 The prognostic-nutritional index in HPV-negative head and neck squamous cell carcinoma treated with upfront surgery: a multi-institutional… PMID:37204841 | 2023 | this review only | not stated | not extracted yet |
| Tu 2015 Preoperative neutrophil-to-lymphocyte ratio is an independent prognostic marker in patients with laryngeal squamous cell carcinoma. PMID:26482899 | 2015 | this review only | not stated | not extracted yet |
| Valdes 2020 Inflammatory markers as prognostic factors of recurrence in advanced-stage squamous cell carcinoma of the head and neck. PMID:32669922 | 2020 | this review only | not stated | not extracted yet |
| Wakisaka 2024 Prognostic Value of the 18F-FDG PET/CT and Haematological Parameters in Head and Neck Cancer. PMID:38950901 | 2024 | this review only | not stated | not extracted yet |
| Wang 2022 High fibrinogen-albumin ratio index (FARI) predicts poor survival in head and neck squamous cell carcinoma patients treated with surgical… PMID:35462579 | 2022 | this review only | not stated | not extracted yet |
| Wang 2024 Prognostic significances of systemic inflammatory response markers in patients with synchronous esophageal and head and neck cancers. PMID:38344911 | 2024 | this review only | not stated | not extracted yet |
| Wang 2025 Nomogram-derived immune-inflammation-nutrition score could act as a novel prognostic indicator for patients with head and neck squamous… PMID:39877368 | 2024 | this review only | not stated | not extracted yet |
| Xun 2020 Prognostic Analysis of Preoperative Inflammatory Biomarkers in Patients With Laryngeal Squamous Cell Carcinoma. PMID:31569972 | 2020 | this review only | not stated | not extracted yet |
| Yamahara 2021 Pretherapeutic nutritional/inflammatory factors as predictors for survival of both early and advanced staged head and neck cancer patients. PMID:33261982 | 2021 | this review only | not stated | not extracted yet |
| Yang 2018 Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for hypopharyngeal squamous cell carcinoma. PMID:29607744 | 2018 | this review only | not stated | not extracted yet |
| Yanni 2022 Neutrophil-to-lymphocyte ratio as a prognostic marker for head and neck cancer with lung metastasis: a retrospective study. PMID:35099595 | 2022 | this review only | not stated | not extracted yet |
| Yao 2019 Prognostic value of neutrophil-to-lymphocyte ratio in advanced nasopharyngeal carcinoma: a large institution-based cohort study from an… PMID:30621619 | 2019 | this review only | not stated | not extracted yet |
| Ye 2018 Prognostic values of hematological biomarkers in nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy. PMID:29589142 | 2018 | this review only | not stated | not extracted yet |
| Ye 2020 Prognosis Value of Platelet Counts, Albumin and Neutrophil-Lymphocyte Ratio of Locoregional Recurrence in Patients with Operable Head and… PMID:32099469 | 2020 | this review only | not stated | not extracted yet |
| Yun 2023 Prognostic Significance of the Post-Treatment Neutrophil-to-Lymphocyte Ratio in Pharyngeal Cancers Treated with Concurrent… PMID:36831590 | 2023 | this review only | not stated | not extracted yet |
| Zeng 2016 Pre-treatment neutrophil-to-lymphocyte ratio predicts prognosis in patients with locoregionally advanced laryngeal carcinoma treated with… PMID:26611205 | 2016 | this review only | not stated | not extracted yet |
| Zeng 2020 Development and validation of immune inflammation-based index for predicting the clinical outcome in patients with nasopharyngeal carcinoma. PMID:32603520 | 2020 | this review only | not stated | not extracted yet |
| Zhong 2019 Prognostic Value Of The Preoperative Neutrophil To Lymphocyte Ratio In Patients With Sinonasal Squamous Cell Carcinoma. PMID:31814768 | 2019 | this review only | not stated | not extracted yet |
| Zhou 2020 Prognostic value of systemic inflammatory marker in patients with head and neck squamous cell carcinoma undergoing surgical resection. PMID:32166977 | 2020 | this review only | not stated | not extracted yet |
| Zhou 2023 Correlation between preoperative peripheral blood NLR, PLR, LMR and prognosis of patients with head and neck squamous cell carcinoma. PMID:38110870 | 2023 | this review only | not stated | not extracted yet |
| Zhu 2024 Prognostic significance and immune escape implication of tumor-infiltrating neutrophil plasticity in human head and neck squamous cell… PMID:38358636 | 2024 | this review only | not stated | not extracted yet |
| Zhu 2024 Prolonged Survival of Neutrophils Induced by Tumor-Derived G-CSF/GM-CSF Promotes Immunosuppression and Progression in Laryngeal Squamous… PMID:39447112 | 2024 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients diagnosed with HNSCC confirmed by histopathology | Patients with HNSCC (n=26 324; 100 studies; 22 countries; studies of 41 to 1550 participants) |
| Intervention | Measurement of pretreatment NLR in peripheral blood and assessment of TANs | High pretreatment peripheral blood NLR (100 studies); TAN density (5 studies, narrative) |
| Comparison | Patients with lower NLR values below the cutoff threshold and lower TAN densities | Low NLR below the study cutoff (cutoffs 1 to >6) |
| Outcomes | Survival endpoints (OS, PFS, DFS, DSS, RFS) expressed as hazard ratios with 95% CI | OS (67 uni, 76 multi cohorts), PFS (14, 21), DFS (23, 16), DSS (9, 9), RFS (6, 5); pooled HRs |
| Study designs | Human clinical studies, including cohort studies and retrospective analyses | Cohort and retrospective studies published 1990 to 2025 |
| Timing | Pretreatment | Pretreatment NLR |