Non-Cochrane · prognostic · PM42011275
Cyclooxygenase-2 (COX-2) as a Potential Prognostic Marker in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.
Qasem Hanan M, Odat Ramez M, Alshwayyat Sakhr, et al. · Health science reports · 2026 · PubMed · doi:10.1002/hsr2.72406
Findings
Population Patients with oral squamous cell carcinoma (including oral tongue SCC)
5 findings
| High COX-2 expression (immunohistochemistry) | Low COX-2 expression | Progression-free survival Tissue samples, immunohistochemistry | HR 1.86 [1.21, 2.87] GRADE not reported 3 studies |
| High COX-2 expression (immunohistochemistry) | Low COX-2 expression | Advanced T stage (T3/T4) Tissue samples, immunohistochemistry | OR 2.91 [1.52, 5.55] GRADE not reported 3 studies · 203 participants |
| High COX-2 expression (immunohistochemistry) | Low COX-2 expression | Advanced TNM stage (III/IV) Tissue samples, immunohistochemistry | OR 2.68 [1.43, 5.02] GRADE not reported 3 studies · 203 participants |
| High COX-2 expression (immunohistochemistry) | Low COX-2 expression | Lymph node metastasis Tissue samples, immunohistochemistry | OR 2.16 [0.71, 6.57] GRADE not reported 3 studies · 203 participants |
| High COX-2 expression (immunohistochemistry) | Low COX-2 expression | Overall survival Tissue samples, immunohistochemistry | HR 1.49 [1.06, 2.1] GRADE not reported 8 studies |
Included primary studies 20
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Sano 2017 Correlation of Inflammatory Markers, Survival, and COX2 Expression in Oral Cancer and Implications for Prognosis. PMID:29359615 | 2018 | 2 other reviews | Overall survival; Progression-free survival | not extracted yet |
| Ali 2018 Significance of immunohistochemical overexpression of cyclooxygenase-2 in overall and disease-free survival of oral squamous cell… DOI:10.1017/s0022215118002207 | 2018 | this review only | not stated | not extracted yet |
| Ali 2018 Significance of immunohistochemical overexpression of cyclooxygenase-2 in overall and disease-free survival of oral squamous cell… PMID:30674365 | 2018 | this review only | Overall survival; Progression-free survival | not extracted yet |
| Baghban 2016 Combined Analysis of Vascular Endothelial Growth Factor Expression with Cyclooxygenase-2 and Mast Cell Density in Oral Squamous Cell… DOI:10.1159/000447778 | 2016 | this review only | not stated | not extracted yet |
| Baghban 2016 Combined Analysis of Vascular Endothelial Growth Factor Expression with Cyclooxygenase-2 and Mast Cell Density in Oral Squamous Cell… PMID:27577989 | 2017 | this review only | Overall survival | not extracted yet |
| Byatnal 2015 Cyclooxygenase-2 – An Imperative Prognostic Biomarker in Oral Squamous Cell Carcinoma- An Immunohistochemical Study DOI:10.1007/s12253-015-9940-9 | 2015 | this review only | not stated | not extracted yet |
| Byatnal 2015 Cyclooxygenase-2--An Imperative Prognostic Biomarker in Oral Squamous Cell Carcinoma--An Immunohistochemical Study. PMID:25962348 | 2015 | this review only | not stated | not extracted yet |
| Cha 2010 Association between expression of embryonic lethal abnormal vision‐like protein HuR and cyclooxygenase‐2 in oral squamous cell carcinoma DOI:10.1002/hed.21507 | 2010 | this review only | not stated | not extracted yet |
| Cha 2010 Association between expression of embryonic lethal abnormal vision-like protein HuR and cyclooxygenase-2 in oral squamous cell carcinoma. PMID:20960565 | 2011 | this review only | Overall survival; Advanced T stage (T3/T4); Advanced TNM stage (III/IV); Lymph node metastasis | not extracted yet |
| Itoh 2003 Immunohistochemical study on overexpression of cyclooxygenase-2 in squamous cell carcinoma of the oral cavity: its importance as a… DOI:10.1016/s1368-8375(03)00105-2 | 2003 | this review only | not stated | not extracted yet |
| Itoh 2003 Immunohistochemical study on overexpression of cyclooxygenase-2 in squamous cell carcinoma of the oral cavity: its importance as a… PMID:13679206 | 2003 | this review only | Overall survival; Progression-free survival | not extracted yet |
| Kim 2011 Significance of molecular markers in survival prediction of oral squamous cell carcinoma DOI:10.1002/hed.21856 | 2011 | this review only | not stated | not extracted yet |
| Kim 2011 Significance of molecular markers in survival prediction of oral squamous cell carcinoma. PMID:22128038 | 2012 | this review only | Overall survival | not extracted yet |
| Kono 2013 Cyclo-Oxygenase–2 Expression Is Associated With Vascular Endothelial Growth Factor C Expression and Lymph Node Metastasis in Oral Squamous… DOI:10.1016/j.joms.2013.04.015 | 2013 | this review only | not stated | not extracted yet |
| Kono 2013 Cyclo-oxygenase-2 expression is associated with vascular endothelial growth factor C expression and lymph node metastasis in oral squamous… PMID:23809761 | 2013 | this review only | Overall survival; Advanced T stage (T3/T4); Advanced TNM stage (III/IV); Lymph node metastasis | not extracted yet |
| Morita 2014 Cyclooxygenase-2 expression is associated with vascular endothelial growth factor-c and lymph node metastasis in human oral tongue cancer DOI:10.1016/j.oooo.2013.12.410 | 2014 | this review only | not stated | not extracted yet |
| Morita 2014 Cyclooxygenase-2 expression is associated with vascular endothelial growth factor-c and lymph node metastasis in human oral tongue cancer. PMID:24560404 | 2014 | this review only | Overall survival; Advanced T stage (T3/T4); Advanced TNM stage (III/IV); Lymph node metastasis | not extracted yet |
| Ryott 2011 Cyclooxygenase‐2 expression in oral tongue squamous cell carcinoma DOI:10.1111/j.1600-0714.2010.00992.x | 2010 | this review only | not stated | not extracted yet |
| Ryott 2011 Cyclooxygenase-2 expression in oral tongue squamous cell carcinoma. PMID:21481000 | 2011 | this review only | not stated | not extracted yet |
| Sano 2017 Correlation of Inflammatory Markers, Survival, and COX2 Expression in Oral Cancer and Implications for Prognosis DOI:10.1177/0194599817745284 | 2018 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Human patients with oral squamous cell carcinoma (tongue SCC included) | 776 patients with OSCC across 10 studies (448 high expressors, 319 low expressors); 2 studies in tongue SCC, 8 in OSCC |
| Intervention | High COX-2 expression by immunohistochemistry | High COX-2 expression by immunohistochemistry (n=448) |
| Comparison | Low COX-2 expression | Low COX-2 expression (n=319) |
| Outcomes | Overall survival, disease-free survival; clinicopathological features | Overall survival (8 studies); progression-free survival (3); advanced T stage (3); advanced TNM stage (3); lymph node metastasis (3) |
| Study designs | Observational studies (case-control, cohort, cross-sectional), English language, peer reviewed | 10 observational cohort studies (Japan 4, Korea 2, Sweden 1, Iran 1, Pakistan 1, India 1) |
| Timing | Not specified | Follow-up median or mean 29 to 58.5 months where reported |