Primary study · included by 1 review

Cyclo-oxygenase-2 expression is associated with vascular endothelial growth factor C expression and lymph node metastasis in oral squamous cell carcinoma.

Kono 2013 · Kono Michihide, Watanabe Masato, Abukawa Harutsugi, et al. · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2013

Included by

Cyclooxygenase-2 (COX-2) as a Potential Prognostic Marker in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.

Non-Cochrane · prognostic · 2026 · cited as Kono 2013 · Figure 2

Outcome this study informs	Pooled effect	Evidence	Certainty
Advanced TNM stage (III/IV) High COX-2 expression (immunohistochemistry) vs Low COX-2 expression	OR 2.68 [1.43, 5.02]	3 studies · 203 participants	GRADE not reported
Advanced T stage (T3/T4) High COX-2 expression (immunohistochemistry) vs Low COX-2 expression	OR 2.91 [1.52, 5.55]	3 studies · 203 participants	GRADE not reported
Lymph node metastasis High COX-2 expression (immunohistochemistry) vs Low COX-2 expression	OR 2.16 [0.71, 6.57]	3 studies · 203 participants	GRADE not reported
Overall survival High COX-2 expression (immunohistochemistry) vs Low COX-2 expression	HR 1.49 [1.06, 2.1]	8 studies	GRADE not reported

1 including review in total.