Non-Cochrane · aetiology · PM42353883
Genetic Variants and Dental Caries Susceptibility: An Umbrella Review and Multilevel Meta-Analysis.
Khalifa Halah, Bahanan Lina, Yousif Johansson Ranna, et al. · Genes · 2026 · PubMed · doi:10.3390/genes17060724
Findings
68 findings
| Population | ||||
|---|---|---|---|---|
| People with and without dental caries (primary studies in included systematic reviews); tooth development and mineralization (TDM) genes | Pooled effect of TDM genes, unadjusted | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · Unadjusted pooled effect | OR 0.94 [0.91, 0.97] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); tooth development and mineralization (TDM) genes | MMP13 rs2252070 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · MMP13 | OR 0.81 [0.42, 1.54] GRADE not reported 6 studies |
| People with and without dental caries (primary studies in included systematic reviews); tooth development and mineralization (TDM) genes | AMELX rs17878486 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · AMELX | OR 1.55 [0.79, 3.03] GRADE not reported 7 studies |
| People with and without dental caries (primary studies in included systematic reviews); tooth development and mineralization (TDM) genes | Dominant genetic model/genotype in tooth development and mineralization (TDM) genes | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · Genetic model or genotype | OR 1.01 [0.88, 1.15] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); tooth development and mineralization (TDM) genes | ENAM rs1264848 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · ENAM | OR 0.94 [0.48, 1.84] GRADE not reported 5 studies |
| People of all ages in primary genetic association studies included in the systematic reviews | Genetic variants in Tooth development and mineralization (TDM) genes (variant allele or genotype) | Reference allele or genotype | Dental caries susceptibility: TDM genetic model, Recessive versus allelic reference genetic model: Recessive | OR 0.97 [0.84, 1.12] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); tooth development and mineralization (TDM) genes | MMP9 rs17576 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · MMP9 | OR 0.93 [0.47, 1.85] GRADE not reported 3 studies |
| People of all ages in primary genetic association studies included in the systematic reviews | Genetic variants in Tooth development and mineralization (TDM) genes (variant allele or genotype) | Reference allele or genotype | Dental caries susceptibility: TDM genetic model, Heterozygote versus allelic reference genetic model: Heterozygote | OR 0.99 [0.86, 1.13] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); tooth development and mineralization (TDM) genes | MMP20 rs1784418 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · MMP20 | OR 0.91 [0.48, 1.71] GRADE not reported 12 studies |
| People with and without dental caries (primary studies in included systematic reviews); tooth development and mineralization (TDM) genes | ENAM rs12640848 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · ENAM | OR 1.06 [0.55, 2.05] GRADE not reported 6 studies |
| People with and without dental caries (primary studies in included systematic reviews); tooth development and mineralization (TDM) genes | Wild genetic model/genotype in tooth development and mineralization (TDM) genes | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · Genetic model or genotype | OR 0.82 [0.63, 1.07] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); tooth development and mineralization (TDM) genes | Pooled effect of tooth development and mineralization (TDM) genes polymorphisms | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries | OR 1.01 [0.86, 1.17] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); tooth development and mineralization (TDM) genes | ENAM rs3796704 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · ENAM | OR 1.22 [0.61, 2.45] GRADE not reported 4 studies |
| People with and without dental caries (primary studies in included systematic reviews); tooth development and mineralization (TDM) genes | AMELX rs2106416 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · AMELX | OR 0.92 [0.33, 2.6] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); tooth development and mineralization (TDM) genes | TFIP11 rs5997096 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · TFIP11 | OR 0.74 [0.31, 1.77] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); tooth development and mineralization (TDM) genes | KLK4 rs2235091 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · KLK4 | OR 1.22 [0.63, 2.39] GRADE not reported 5 studies |
| People with and without dental caries (primary studies in included systematic reviews); tooth development and mineralization (TDM) genes | Homozygous genetic model/genotype in tooth development and mineralization (TDM) genes | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · Genetic model or genotype | OR 0.99 [0.87, 1.14] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); tooth development and mineralization (TDM) genes | ENAM rs3796703 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · ENAM | OR 1.09 [0.54, 2.19] GRADE not reported 4 studies |
| People with and without dental caries (primary studies in included systematic reviews); vitamin D receptor (VDR) gene | Recessive genetic model/genotype in vitamin D receptor (VDR) gene | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · Genetic model or genotype | OR 1.05 [0.91, 1.2] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); vitamin D receptor (VDR) gene | VDR rs11568820 (Cdx2) polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · VDR | OR 0.66 [0.46, 0.95] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); vitamin D receptor (VDR) gene | VDR rs1544410 (BsmI) polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · VDR | OR 0.92 [0.63, 1.36] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); vitamin D receptor (VDR) gene | VDR rs7975232 (ApaI) polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · VDR | OR 0.96 [0.69, 1.32] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); vitamin D receptor (VDR) gene | Dominant genetic model/genotype in vitamin D receptor (VDR) gene | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · Genetic model or genotype | OR 0.92 [0.73, 1.16] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); vitamin D receptor (VDR) gene | Heterozygous genetic model/genotype in vitamin D receptor (VDR) gene | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · Genetic model or genotype | OR 1.25 [1.0, 1.57] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); vitamin D receptor (VDR) gene | Over-dominant genetic model/genotype in vitamin D receptor (VDR) gene | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · Genetic model or genotype | OR 1.17 [1.0, 1.37] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); vitamin D receptor (VDR) gene | Pooled effect of vitamin D receptor (VDR) gene polymorphisms | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries | OR 0.96 [0.84, 1.11] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); vitamin D receptor (VDR) gene | VDR rs2228570 (FokI) polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · VDR | OR 1.18 [0.8, 1.75] GRADE not reported Studies not reported |
| People of all ages in primary genetic association studies included in the systematic reviews | Genetic variants in Vitamin D receptor (VDR) genes (variant allele or genotype) | Reference allele or genotype | Dental caries susceptibility: VDR genetic model, Homozygous versus allelic reference genetic model: Homozygous | OR 1.20 [0.88, 1.63] GRADE not reported Studies not reported |
| People of all ages in primary genetic association studies included in the systematic reviews | Genetic variants in Vitamin D receptor (VDR) genes (variant allele or genotype) | Reference allele or genotype | Dental caries susceptibility: VDR rs739837 (3' UTR variant) VDR rs739837 (3' UTR variant) | OR 1.00 [0.71, 1.4] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); vitamin D receptor (VDR) gene | VDR rs731236 (TaqI) polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · VDR | OR 1.0 [0.73, 1.37] GRADE not reported 7 studies |
| People with and without dental caries (primary studies in included systematic reviews); vitamin D receptor (VDR) gene | VDR rs10735810 (FokI) polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · VDR | OR 0.92 [0.66, 1.29] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); salivary composition and function (SCF) genes | MUC5B rs2249073 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · MUC5B | OR 1.11 [0.66, 1.89] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); salivary composition and function (SCF) genes | Homozygous genetic model/genotype in salivary composition and function (SCF) genes | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · Genetic model or genotype | OR 1.26 [0.92, 1.72] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); salivary composition and function (SCF) genes | AQP5 rs10875989 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · AQP5 | OR 1.39 [0.84, 2.28] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); salivary composition and function (SCF) genes | AQP2 rs10864376 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · AQP2 | OR 0.8 [0.46, 1.41] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); salivary composition and function (SCF) genes | AQP2 rs12138897 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · AQP2 | OR 1.8 [0.88, 3.66] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); salivary composition and function (SCF) genes | MUC5B rs2735733 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · MUC5B | OR 0.94 [0.57, 1.57] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); salivary composition and function (SCF) genes | CA6 rs2274333 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · CA6 | OR 0.93 [0.57, 1.51] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); salivary composition and function (SCF) genes | AQP5 rs3759129 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · AQP5 | OR 0.7 [0.41, 1.19] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); salivary composition and function (SCF) genes | Pooled effect of salivary composition and function (SCF) genes polymorphisms | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries | OR 1.07 [0.92, 1.25] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); salivary composition and function (SCF) genes | Heterozygous genetic model/genotype in salivary composition and function (SCF) genes | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · Genetic model or genotype | OR 0.99 [0.77, 1.28] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); salivary composition and function (SCF) genes | CA6 rs2274327 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · CA6 | OR 0.95 [0.56, 1.61] GRADE not reported Studies not reported |
| People of all ages in primary genetic association studies included in the systematic reviews | Genetic variants in Salivary composition and function (SCF) genes (variant allele or genotype) | Reference allele or genotype | Dental caries susceptibility: MUC5B rs2857476 MUC5B rs2857476 | OR 1.12 [0.66, 1.89] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); salivary composition and function (SCF) genes | AQP5 rs923911 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · AQP5 | OR 1.02 [0.57, 1.83] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); salivary composition and function (SCF) genes | AQP5 rs17032907 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · AQP5 | OR 1.48 [0.77, 2.86] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); salivary composition and function (SCF) genes | CA6 rs2274328 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · CA6 | OR 0.94 [0.52, 1.68] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); salivary composition and function (SCF) genes | AQP5 rs1996315 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · AQP5 | OR 0.92 [0.52, 1.61] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); salivary composition and function (SCF) genes | AQP2 rs12021597 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · AQP2 | OR 1.9 [0.88, 4.11] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); immune and inflammatory response (IMR) genes | LTF rs1126478 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · LTF | OR 1.04 [0.71, 1.52] GRADE not reported 5 studies |
| People with and without dental caries (primary studies in included systematic reviews); immune and inflammatory response (IMR) genes | DEFB1 rs1800972 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · DEFB1 | OR 1.26 [0.65, 2.46] GRADE not reported 2 studies |
| People with and without dental caries (primary studies in included systematic reviews); immune and inflammatory response (IMR) genes | DEFB1 rs1799946 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · DEFB1 | OR 0.9 [0.66, 1.23] GRADE not reported 2 studies |
| People with and without dental caries (primary studies in included systematic reviews); immune and inflammatory response (IMR) genes | Heterozygous genetic model/genotype in immune and inflammatory response (IMR) genes | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · Genetic model or genotype | OR 0.99 [0.81, 1.22] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); immune and inflammatory response (IMR) genes | MBL2 rs1800450 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · MBL2 | OR 1.48 [1.03, 2.14] GRADE not reported 3 studies |
| People with and without dental caries (primary studies in included systematic reviews); immune and inflammatory response (IMR) genes | Homozygous genetic model/genotype in immune and inflammatory response (IMR) genes | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · Genetic model or genotype | OR 0.94 [0.72, 1.21] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); immune and inflammatory response (IMR) genes | Pooled effect of immune and inflammatory response (IMR) genes polymorphisms | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries | OR 1.06 [0.96, 1.17] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); immune and inflammatory response (IMR) genes | DEFB1 rs11362 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · DEFB1 | OR 1.2 [0.89, 1.62] GRADE not reported 4 studies |
| People with and without dental caries (primary studies in included systematic reviews); immune and inflammatory response (IMR) genes | Dominant genetic model/genotype in immune and inflammatory response (IMR) genes | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · Genetic model or genotype | OR 1.01 [0.82, 1.25] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); immune and inflammatory response (IMR) genes | Wild genetic model/genotype in immune and inflammatory response (IMR) genes | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · Genetic model or genotype | OR 1.01 [0.72, 1.43] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); immune and inflammatory response (IMR) genes | MBL2 rs7096206 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · MBL2 | OR 0.95 [0.66, 1.37] GRADE not reported 3 studies |
| People with and without dental caries (primary studies in included systematic reviews); immune and inflammatory response (IMR) genes | Recessive genetic model/genotype in immune and inflammatory response (IMR) genes | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · Genetic model or genotype | OR 0.95 [0.76, 1.21] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); taste perception and signaling (TPS) genes | Pooled effect of taste perception and signaling (TPS) genes polymorphisms | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries | OR 0.57 [0.15, 2.16] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); taste perception and signaling (TPS) genes | TAS2R38 rs713598 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · TAS2R38 | OR 0.26 [0.09, 0.73] GRADE not reported 2 studies |
| People with and without dental caries (primary studies in included systematic reviews); taste perception and signaling (TPS) genes | Heterozygous genetic model/genotype in taste perception and signaling (TPS) genes | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · Genetic model or genotype | OR 0.92 [0.76, 1.12] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); taste perception and signaling (TPS) genes | TAS1R2 rs35874116 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · TAS1R2 | OR 1.04 [0.5, 2.16] GRADE not reported 6 studies |
| People with and without dental caries (primary studies in included systematic reviews); taste perception and signaling (TPS) genes | Homozygous genetic model/genotype in taste perception and signaling (TPS) genes | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · Genetic model or genotype | OR 1.34 [0.94, 1.9] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); taste perception and signaling (TPS) genes | TAS1R2 rs9701796 polymorphism | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · TAS1R2 | OR 1.13 [0.54, 2.37] GRADE not reported 3 studies |
| People with and without dental caries (primary studies in included systematic reviews); taste perception and signaling (TPS) genes | Recessive genetic model/genotype in taste perception and signaling (TPS) genes | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · Genetic model or genotype | OR 1.39 [1.0, 1.95] GRADE not reported Studies not reported |
| People with and without dental caries (primary studies in included systematic reviews); taste perception and signaling (TPS) genes | Dominant genetic model/genotype in taste perception and signaling (TPS) genes | Reference genotype or allele (allelic model as reference) | Dental caries susceptibility (odds) Humans of all ages; primary studies from diverse countries · Genetic model or genotype | OR 0.95 [0.79, 1.15] GRADE not reported Studies not reported |
Included primary studies 58
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Alkuhl et al., 2022 Microvessel reactions and NAD-NADH changes in cat brain cortex during cortical stimulation under normo- and hypercapnic conditions. PMID:202240 | 1977 | 3 other reviews | not stated | not extracted yet |
| Sharifi et al., 2021 Congenital adrenal hyperplasia: simultaneous determination of plasma aldosterone and 17-hydroxyprogesterone. PMID:202131 | 1978 | 3 other reviews | not stated | not extracted yet |
| Ślebioda et al., 2021 Induction of premature parturition in sheep: adrenocorticotrophin and corticosteroid changes during infusion of Synacthen into the foetus. PMID:202133 | 1978 | 3 other reviews | not stated | not extracted yet |
| Li et al., 2023 [Analysis of the nucleotide sequence of DNA]. PMID:202344 | 1977 | 2 other reviews | not stated | not extracted yet |
| Chisini et al., 2020a The relationship between hepatitis B virus infection and hepatic cell carcinoma in Mozambique. PMID:202048 | 1977 | 1 other review | not stated | not extracted yet |
| Chisini et al., 2023 [Electrophoretic study of the nuclear membrane ribonucleases of rat liver and hepatoma-27 cells]. PMID:202350 | 1977 | 1 other review | not stated | not extracted yet |
| Chisini et al., 2025 [Experimental data on the hygienic standardization of silica-containing dust in the air]. PMID:202541 | 1977 | 1 other review | not stated | not extracted yet |
| Hatipoğlu et al. 2020 Regulatory role of guanosine 3',5'-monophosphate in adrenocorticotropin hormone-induced steroidogenesis. PMID:202028 | 1978 | 1 other review | not stated | not extracted yet |
| Lei et al., 2021 Isolated gastric involvement in Crohn's disease. Report of a case simulating scirrhus carcinoma. PMID:202129 | 1976 | 1 other review | not stated | not extracted yet |
| Li et al., 2020 Disturbances of perinatal carbohydrate metabolism in rats exposed to methylmercury in utero. PMID:202042 | 1977 | 1 other review | not stated | not extracted yet |
| Motahari et al., 2024 Perinatally acquired viral infections. PMID:202435 | 1977 | 1 other review | not stated | not extracted yet |
| Najafi-Ghobadi et al., 2023 Formation of guanosine 3',5'-cyclic monophosphate by thyroliberin in cultured rat pituitary cells. A possible role in stimulation of… PMID:202336 | 1978 | 1 other review | not stated | not extracted yet |
| Sharifi et al., 2020 Origins of prokaryotes, eukaryotes, mitochondria, and chloroplasts. PMID:202030 | 1978 | 1 other review | not stated | not extracted yet |
| Sharma et al., 2023 Single and multiple turnover reactions in the ubiquinone-cytochrome b-c2 oxidoreductase of Rhodopseudomonas sphaeroids: the physical… PMID:202311 | 1977 | 1 other review | not stated | not extracted yet |
| Zhou et al., 2025 The activity of some intracellular oxidative enzymes in the thyroid follicular epithelium of Xenopus laevis Daud. in experimental… PMID:202546 | 1977 | 1 other review | not stated | not extracted yet |
| Alkuhl 2022 Genetic taste sensitivity and dental caries in children and adolescents: A systematic review and meta‐analysis DOI:10.1111/ipd.12845 | 2021 | this review only | not stated | not extracted yet |
| Aruna 2023 Association between polymorphisms of immune response genes and early childhood caries - systematic review, gene-based, gene cluster, and… PMID:37971556 | 2023 | this review only | not stated | not extracted yet |
| Aruna et al., 2023 The effect of quaternary structure on the state of the alpha and beta subunits within nitrosyl haemoglobin. Low temperature… PMID:202327 | 1978 | this review only | not stated | not extracted yet |
| Cavallari 2019 Dental caries: Genetic and protein interactions. PMID:31476523 | 2019 | this review only | not stated | not extracted yet |
| Cavallari et al., 2019 Adenosine as inhibitor of myocardial effects of catecholamines. PMID:201920 | 1977 | this review only | not stated | not extracted yet |
| Chisini 2020a Genes and SNPs in the pathway of immune response and caries risk: a systematic review and meta-analysis. PMID:33327793 | 2020 | this review only | not stated | not extracted yet |
| Chisini 2020b Genes in the pathway of tooth mineral tissues and dental caries risk: a systematic review and meta-analysis. PMID:32945961 | 2020 | this review only | not stated | not extracted yet |
| Chisini 2021 Single nucleotide polymorphisms of taste genes and caries: a systematic review and meta-analysis DOI:10.1080/00016357.2020.1832253 | 2020 | this review only | not stated | not extracted yet |
| Chisini 2023 Genes and single nucleotide polymorphisms in the pathway of saliva and dental caries: a systematic review and meta-analysis. PMID:36644905 | 2023 | this review only | not stated | not extracted yet |
| Chisini 2025 Pathways of the vitamin D receptor gene and dental caries: A systematic review and meta-analysis. PMID:39986212 | 2025 | this review only | not stated | not extracted yet |
| Chisini et al., 2020b Experimental infection of Nigerian sheep and goats with bovine virus diarrhoea virus. PMID:202049 | 1977 | this review only | not stated | not extracted yet |
| Chisini et al., 2021 Ocular herpes simplex infection. A clinical evaluation of virus isolation and studies on iodo-deoxyuridine resistance. PMID:202139 | 1977 | this review only | not stated | not extracted yet |
| Hatipoglu 2019 Effects of the carbonic anhydrase VI gene polymorphisms on dental caries: A meta-analysis. PMID:31895503 | 2019 | this review only | not stated | not extracted yet |
| Hatipoğlu 2020 Association between rs11362 polymorphism in the beta-defensin 1 (DEFB1) gene and dental caries: A meta-analysis. PMID:32603779 | 2020 | this review only | not stated | not extracted yet |
| Hatipoglu et al., 2019 [Rotavirus infections]. PMID:201913 | 1977 | this review only | not stated | not extracted yet |
| Hemati 2023 Evaluation of Beta-Defensin 1 and Mannose-Binding Lectin 2 Polymorphisms in Children with Dental Caries Compared to Caries-Free Controls:… PMID:36832361 | 2023 | this review only | not stated | not extracted yet |
| Hemati et al., 2023 [Preparative method of isolating phosphoinositide fractions from brain tissue]. PMID:202343 | 1977 | this review only | not stated | not extracted yet |
| Lei 2021 Association Between the TaqI (rs731236 T>C) Gene Polymorphism and Dental Caries Risk: A Meta-analysis. PMID:33960841 | 2021 | this review only | not stated | not extracted yet |
| Li 2020 The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based analysis. PMID:32460726 | 2020 | this review only | not stated | not extracted yet |
| Li 2021 Association of genetic variants in enamel-formation genes with dental caries: A meta- and gene-cluster analysis. PMID:33732050 | 2021 | this review only | not stated | not extracted yet |
| Li 2023 Association of KLK4 rs2235091 polymorphism with susceptibility to dental caries: a systematic review and meta-analysis. PMID:37711595 | 2023 | this review only | not stated | not extracted yet |
| Li et al., 2021 [The influence of nervous system lesions on the course of adjuvant arthritis]. PMID:202110 | 1977 | this review only | not stated | not extracted yet |
| Lips 2017 Salivary protein polymorphisms and risk of dental caries: a systematic review. PMID:28591238 | 2017 | this review only | not stated | not extracted yet |
| Lips et al., 2017 Median--ulnar nerve communications and carpal tunnel syndrome. PMID:201732 | 1977 | this review only | not stated | not extracted yet |
| Molaei 2022 Association of MMP9, MMP13 and MMP20 genes polymorphism with dental caries: A meta-analysis DOI:10.1016/j.pdj.2022.09.002 | 2022 | this review only | not stated | not extracted yet |
| Molaei et al., 2022 Congenital infection in the premature infant: trials and tribulations. PMID:202234 | 1977 | this review only | not stated | not extracted yet |
| Motahari 2024 Association of TAS1R2 (rs35874116 or rs9701796) Gene Polymorphism with Dental Caries: A Systematic Review and Meta-analysis DOI:10.2174/0118742106275130240109051833 | 2024 | this review only | not stated | not extracted yet |
| Najafi-Ghobadi 2023 The association between MMP13 rs2252070 polymorphism and caries susceptibility: A systematic review and meta-analysis DOI:10.1016/j.humgen.2023.201143 | 2023 | this review only | not stated | not extracted yet |
| Nireeksha 2021 Antimicrobial Peptide Cathelicidin and Vitamin D Receptor Gene Polymorphism in Oral Health DOI:10.37506/ijfmt.v15i4.16997 | 2021 | this review only | not stated | not extracted yet |
| Nireeksha et al., 2021 Evidence for neurosecretory substance in neurons in the small intestine of dogs. PMID:202137 | 1976 | this review only | not stated | not extracted yet |
| Piekoszewska-Ziętek 2017 Single Nucleotide Polymorphism in the Aetiology of Caries: Systematic Literature Review DOI:10.1159/000476075 | 2017 | this review only | not stated | not extracted yet |
| Piekoszewska-Ziętek et al., 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Qin 2024 Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and meta-analysis. PMID:39394075 | 2024 | this review only | not stated | not extracted yet |
| Qin et al., 2024 Environmental effects on the central nervous system. PMID:202447 | 1977 | this review only | not stated | not extracted yet |
| Sadeghi 2021 The Most Common Vitamin D Receptor Polymorphisms (ApaI,FokI, TaqI, BsmI, and BglI) in Children with Dental Caries: A Systematic Review and… PMID:33920959 | 2021 | this review only | not stated | not extracted yet |
| Sadeghi et al., 2021 Enzyme activity in the pulp following preparation of cavities and insertion of medicaments in cavities in monkey teeth. PMID:202138 | 1977 | this review only | not stated | not extracted yet |
| Sharifi 2020 Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. PMID:32375748 | 2020 | this review only | not stated | not extracted yet |
| Sharifi 2021 A systematic review and meta-analysis of CA VI, AMBN, and TUFT1 polymorphisms and dental caries risk DOI:10.1016/j.mgene.2021.100866 | 2021 | this review only | not stated | not extracted yet |
| Sharma 2023 Single nucleotide polymorphisms of enamel formation genes and early childhood caries - systematic review, gene-based, gene cluster and… PMID:37282406 | 2023 | this review only | not stated | not extracted yet |
| Shojaei 2026 The Role of LTF, ENAM, and AMELX Gene Polymorphisms in Dental Caries Susceptibility: A Meta-Analysis DOI:10.1007/s40142-026-00237-6 | 2026 | this review only | not stated | not extracted yet |
| Shojaei et al., 2026 PMID:202645 | NR | this review only | not stated | not extracted yet |
| Ślebioda 2021 <i>Beta‐defensin 1</i> gene polymorphisms in the pathologies of the oral cavity—Data from meta‐analysis: Association only with rs1047031… DOI:10.1111/jop.13136 | 2020 | this review only | not stated | not extracted yet |
| Zhou 2025 Genome-Wide Association Studies on Dental Caries: A Systematic Review. PMID:41032477 | 2025 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Human subjects of all ages, sexes and ethnicities | Participants of case-control, cross-sectional and cohort studies and GWAS, aged about 20 months to 93 years |
| Intervention | Any genetic variant (SNP) studied in relation to dental caries | Polymorphisms in TDM, VDR, SCF, IMR and TPS genes |
| Comparison | Reference allele or genotype | Reference allele or genotype |
| Outcomes | Association of genetic variants with dental caries susceptibility (odds ratio) | Dental caries (DMFT/dmft, DMFS, ICDAS and others); multilevel adjusted OR |
| Study designs | Systematic reviews, with or without meta-analysis, in English | 29 systematic reviews (4 moderate, 10 low, 15 critically low AMSTAR 2 quality) |
| Timing | Not specified | Not specified |