Non-Cochrane · intervention · PM41585970
Comparison of platelet rich plasma and injectable steroids in the treatment of oral lichen planus: A systematic review and meta-analysis.
Kumar Ajay, Srivastava Adit, Sah Neha, et al. · National journal of maxillofacial surgery · 2025 · PubMed · doi:10.4103/njms.njms_18_25
Findings
Population Patients with oral lichen planus requiring treatment
1 finding
| Platelet-rich plasma (PRP) injection | Injectable steroids | Post-treatment pain score (VAS/NRS) Post-treatment · Not specified · Overall | SMD -0.16 [-1.13, 0.80] GRADE not reported 4 studies |
Included primary studies 17
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Choudhary 2023 Single and multiple turnover reactions in the ubiquinone-cytochrome b-c2 oxidoreductase of Rhodopseudomonas sphaeroids: the physical… PMID:202311 | 1977 | 1 other review | not stated | not extracted yet |
| Sobhy 2023 Guanosine 3',5'-monophosphate: a central nervous system regulator of analgesia. PMID:202029 | 1978 | 1 other review | not stated | not extracted yet |
| Ahuja 2020 Comparative evaluation of effectiveness of autologous platelet rich plasma and intralesional corticosteroids in the management of erosive… DOI:10.1016/j.jobcr.2020.09.008 | 2020 | this review only | not stated | not extracted yet |
| Ahuja 2020 Comparative evaluation of effectiveness of autologous platelet rich plasma and intralesional corticosteroids in the management of erosive… PMID:33088702 | 2020 | this review only | not stated | not extracted yet |
| Choudhary 2023 Spontaneous arteriovenous shunt after microsurgical operation. PMID:20231116 | 2010 | this review only | not stated | not extracted yet |
| El-Shinnawi 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| El-Shinnawi 2021 Replication of type I herpes simplex virus in primary cultures of hairy cell leukemic leukocytes. PMID:202167 | 1978 | this review only | not stated | not extracted yet |
| ElGhareeb 2023 Intralesional injection of platelet‐rich plasma versus steroid in the treatment of oral lichen planus DOI:10.1111/jocd.15622 | 2023 | this review only | not stated | not extracted yet |
| ElGhareeb 2023 Intralesional injection of platelet-rich plasma versus steroid in the treatment of oral lichen planus. PMID:36718838 | 2023 | this review only | not stated | not extracted yet |
| Hijazi 2022 Efficacy of intralesional injections of platelet‐rich plasma in patients with oral lichen planus: A pilot randomized clinical trial DOI:10.1002/cre2.550 | 2022 | this review only | not stated | not extracted yet |
| Hijazi 2022 Efficacy of intralesional injections of platelet-rich plasma in patients with oral lichen planus: A pilot randomized clinical trial. PMID:35218680 | 2022 | this review only | not stated | not extracted yet |
| Lore 2018 Oral lichen planus: therapy and phenotype DOI:10.23736/s0392-0488.16.05399-2 | 2018 | this review only | not stated | not extracted yet |
| Lore 2018 Oral lichen planus: therapy and phenotype. PMID:27982545 | 2018 | this review only | not stated | not extracted yet |
| Pinas 2017 Biomolecules in the treatment of lichen planus refractory to corticosteroid therapy: Clinical and histopathological assessment DOI:10.1016/j.aanat.2017.12.006 | 2018 | this review only | not stated | not extracted yet |
| Pinas 2017 Biomolecules in the treatment of lichen planus refractory to corticosteroid therapy: Clinical and histopathological assessment. PMID:29301093 | 2018 | this review only | not stated | not extracted yet |
| Sharma 2023 Comparative evaluation of autologous platelet rich plasma and triamcinolone acetonide injection in the management of erosive lichen planus… DOI:10.18203/2319-2003.ijbcp20231125 | 2023 | this review only | not stated | not extracted yet |
| Sobhy 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients diagnosed with oral lichen planus requiring treatment | Patients with oral lichen planus, mostly erosive (n=266 in 9 RCTs) |
| Intervention | Platelet-rich plasma | PRP injection or PRP gel (n=9 studies) |
| Comparison | Injectable steroids | Injectable steroids (triamcinolone); one study used cyclosporine mouthwash |
| Outcomes | Pain (NRS or VAS), clinical presentation (Thongprasom scale), lesion size | Pain/VAS, burning sensation, lesion size; meta-analysis of post-treatment pain in 4 studies |
| Study designs | RCTs and case reports (English, last 10 years) | 9 RCTs published 2017 to 2023 |
| Timing | Not specified | Follow-up 2 to 13 months |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | Partial Yes | Partial Yes | yes |
| 3Choice of study designs explained | No | No | yes |
| 4Comprehensive literature searchcritical | Partial Yes | No | no |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | Yes | Yes | yes |
| 7List of excluded studies with reasonscritical | No | No | yes |
| 8Included studies described in detail | Partial Yes | Partial Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | RCT: Yes · NRSI: N/A | RCT: Yes · NRSI: N/A | yes |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | RCT: Yes · NRSI: N/A | RCT: No · NRSI: N/A | no |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | Yes | Yes | yes |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | No | No | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Critically Low | yes |