Non-Cochrane · intervention · PM42866607

Accuracy of robotic systems in dental implant placement with clinical subgroup analyses: A systematic review and meta-analysis.

Linn Thu Ya, Ashry Amal, Abbas Hazem, et al. · The Japanese dental science review · 2026 · PubMed · doi:10.1016/j.jdsr.2026.09.001

Findings

63 findings

Population
Patients receiving dental implants placed with robotic assistanceRobot-assisted computer-aided implant surgery (r-CAIS), any systemPreoperative virtual implant plan (single-arm accuracy; no comparator group)Angular deviation (degrees)
Postoperative (placed versus planned implant position) · Clinical studies, mostly university hospitals and educational centers in China · Arch analysis set: Studies reporting accuracy by arch (18 arch-level estimates from 10 studies)
MEAN 1.35 [1.13, 1.58]
GRADE not reported
10 studies
Patients receiving dental implantsRobot-assisted implant placementPreoperative planned implant positionCoronal deviation (mm)
Study design: Case series
MEAN 0.67 [0.59, 0.74]
GRADE not reported
13 studies
Patients receiving dental implantsRobot-assisted implant placementPreoperative planned implant positionCoronal deviation (mm)
Studies with edentulous span data
MEAN 0.67 [0.61, 0.72]
GRADE not reported
36 studies
Patients receiving dental implants placed with robotic assistanceRobot-assisted computer-aided implant surgery (r-CAIS), any systemPreoperative virtual implant plan (single-arm accuracy; no comparator group)Angular deviation (degrees)
Postoperative (placed versus planned implant position) · Clinical studies, mostly university hospitals and educational centers in China · Intra-arch position analysis set: Studies reporting accuracy by intra-arch position (19 position-level estimates from 12 studies)
MEAN 1.32 [1.05, 1.59]
GRADE not reported
12 studies
Patients receiving dental implantsRobot-assisted implant placementPreoperative planned implant positionApical deviation (mm)
Study design: Case series
MEAN 0.69 [0.6, 0.78]
GRADE not reported
13 studies
Patients receiving dental implants placed with robotic assistanceRobot-assisted computer-aided implant surgery (r-CAIS), any systemPreoperative virtual implant plan (single-arm accuracy; no comparator group)Global coronal deviation (mm)
Postoperative (placed versus planned implant position) · Clinical studies, mostly university hospitals and educational centers in China · Arch analysis set: Studies reporting accuracy by arch (18 arch-level estimates from 10 studies)
MEAN 0.62 [0.55, 0.69]
GRADE not reported
10 studies
Patients receiving dental implantsRobot-assisted implant placementPreoperative planned implant positionAngular deviation (degrees)
Study design: Non-RCTs
MEAN 1.67 [1.4, 1.94]
GRADE not reported
21 studies
Patients receiving dental implantsRobot-assisted implant placementPreoperative planned implant positionApical deviation (mm)
Studies with edentulous span data
MEAN 0.71 [0.64, 0.77]
GRADE not reported
36 studies
Patients receiving dental implantsRobot-assisted implant placementPreoperative planned implant positionCoronal deviation (mm)
Study design: RCTs
MEAN 0.84 [0.67, 1.01]
GRADE not reported
5 studies
Patients receiving dental implantsRobot-assisted implant placementPreoperative planned implant positionAngular deviation (degrees)
Studies with edentulous span data
MEAN 1.58 [1.36, 1.81]
GRADE not reported
36 studies
Patients receiving dental implantsRobot-assisted implant placementPreoperative planned implant positionCoronal deviation (mm)
Study design: Non-RCTs
MEAN 0.66 [0.57, 0.75]
GRADE not reported
21 studies
Patients receiving dental implantsRobot-assisted implant placementPreoperative planned implant positionAngular deviation (degrees)
Study design: Case series
MEAN 1.37 [1.07, 1.67]
GRADE not reported
13 studies
Patients receiving dental implantsRobot-assisted implant placementPreoperative planned implant positionAngular deviation (degrees)
Study design: RCTs
MEAN 2.01 [1.07, 2.95]
GRADE not reported
5 studies
Patients receiving dental implantsRobot-assisted implant placementPreoperative planned implant positionApical deviation (mm)
Study design: RCTs
MEAN 0.92 [0.7, 1.15]
GRADE not reported
5 studies
Patients receiving dental implantsRobot-assisted implant placementPreoperative planned implant positionApical deviation (mm)
Study design: Non-RCTs
MEAN 0.71 [0.62, 0.8]
GRADE not reported
21 studies
Patients receiving dental implantsRobot-assisted implant placementPreoperative planned implant positionApical deviation (mm)
Overall
MEAN 0.72 [0.66, 0.79]
GRADE not reported
39 studies
Patients receiving dental implants placed with robotic assistanceRobot-assisted computer-aided implant surgery (r-CAIS), any systemPreoperative virtual implant plan (single-arm accuracy; no comparator group)Global apical deviation (mm)
Postoperative (placed versus planned implant position) · Clinical studies, mostly university hospitals and educational centers in China · Arch analysis set: Studies reporting accuracy by arch (18 arch-level estimates from 10 studies)
MEAN 0.66 [0.57, 0.74]
GRADE not reported
10 studies
Patients receiving dental implants placed with robotic assistanceRobot-assisted computer-aided implant surgery (r-CAIS), any systemPreoperative virtual implant plan (single-arm accuracy; no comparator group)Global apical deviation (mm)
Postoperative (placed versus planned implant position) · Clinical studies, mostly university hospitals and educational centers in China · Intra-arch position analysis set: Studies reporting accuracy by intra-arch position (19 position-level estimates from 12 studies)
MEAN 0.69 [0.61, 0.77]
GRADE not reported
12 studies
Patients receiving dental implantsRobot-assisted implant placementPreoperative planned implant positionAngular deviation (degrees)
Overall
MEAN 1.6 [1.4, 1.81]
GRADE not reported
39 studies
Patients receiving dental implants placed with robotic assistanceRobot-assisted computer-aided implant surgery (r-CAIS), any systemPreoperative virtual implant plan (single-arm accuracy; no comparator group)Global coronal deviation (mm)
Postoperative (placed versus planned implant position) · Clinical studies, mostly university hospitals and educational centers in China · Intra-arch position analysis set: Studies reporting accuracy by intra-arch position (19 position-level estimates from 12 studies)
MEAN 0.64 [0.57, 0.71]
GRADE not reported
12 studies
Patients receiving dental implantsRobot-assisted implant placementPreoperative planned implant positionCoronal deviation (mm)
Overall
MEAN 0.68 [0.62, 0.74]
GRADE not reported
39 studies
Patients receiving dental implantsRobot-assisted implant placement (Level 2 task autonomous)Preoperative planned implant positionCoronal deviation (mm)
Level 2 task autonomous
MEAN 0.58 [0.52, 0.63]
GRADE not reported
12 studies
Patients receiving dental implantsRobot-assisted implant placement (Level 2 task autonomous)Preoperative planned implant positionAngular deviation (degrees)
Level 2 task autonomous
MEAN 1.46 [1.18, 1.75]
GRADE not reported
12 studies
Patients receiving dental implantsRobot-assisted implant placement (Level 2 task autonomous)Preoperative planned implant positionApical deviation (mm)
Level 2 task autonomous
MEAN 0.64 [0.58, 0.69]
GRADE not reported
12 studies
Patients receiving dental implantsRobot-assisted implant placement (Level 1 semi-autonomous)Preoperative planned implant positionApical deviation (mm)
Level 1 semi-autonomous
MEAN 0.72 [0.65, 0.8]
GRADE not reported
24 studies
Patients receiving dental implantsRobot-assisted implant placement (Level 1 semi-autonomous)Preoperative planned implant positionCoronal deviation (mm)
Level 1 semi-autonomous
MEAN 0.68 [0.62, 0.75]
GRADE not reported
24 studies
Patients receiving dental implantsRobot-assisted implant placement (Level 1 semi-autonomous)Preoperative planned implant positionAngular deviation (degrees)
Level 1 semi-autonomous
MEAN 1.64 [1.34, 1.94]
GRADE not reported
24 studies
Patients receiving dental implantsRobot-assisted implant placement (Level 1 haptic)Preoperative planned implant positionCoronal deviation (mm)
Level 1 haptic
MEAN 1.11 [1.03, 1.18]
GRADE not reported
3 studies
Patients receiving dental implantsRobot-assisted implant placement (Level 1 haptic)Preoperative planned implant positionApical deviation (mm)
Level 1 haptic
MEAN 1.18 [0.86, 1.5]
GRADE not reported
3 studies
Patients receiving dental implantsRobot-assisted implant placement (Level 1 haptic)Preoperative planned implant positionAngular deviation (degrees)
Level 1 haptic
MEAN 2.05 [1.27, 2.83]
GRADE not reported
3 studies
Patients receiving dental implants (Single edentulous space)Robot-assisted implant placementPreoperative planned implant positionApical deviation (mm)
Single edentulous space
MEAN 0.76 [0.66, 0.86]
GRADE not reported
16 studies
Patients receiving dental implants (Single edentulous space)Robot-assisted implant placementPreoperative planned implant positionAngular deviation (degrees)
Single edentulous space
MEAN 1.68 [1.28, 2.09]
GRADE not reported
16 studies
Patients receiving dental implants (Single edentulous space)Robot-assisted implant placementPreoperative planned implant positionCoronal deviation (mm)
Single edentulous space
MEAN 0.72 [0.65, 0.8]
GRADE not reported
16 studies
Patients receiving dental implants (Partially edentulous)Robot-assisted implant placementPreoperative planned implant positionCoronal deviation (mm)
Partially edentulous
MEAN 0.59 [0.51, 0.66]
GRADE not reported
14 studies
Patients receiving dental implants (Partially edentulous)Robot-assisted implant placementPreoperative planned implant positionApical deviation (mm)
Partially edentulous
MEAN 0.64 [0.56, 0.72]
GRADE not reported
14 studies
Patients receiving dental implants (Partially edentulous)Robot-assisted implant placementPreoperative planned implant positionAngular deviation (degrees)
Partially edentulous
MEAN 1.53 [1.2, 1.86]
GRADE not reported
14 studies
Patients receiving dental implants (Completely edentulous)Robot-assisted implant placementPreoperative planned implant positionAngular deviation (degrees)
Completely edentulous
MEAN 1.5 [1.01, 1.98]
GRADE not reported
6 studies
Patients receiving dental implants (Completely edentulous)Robot-assisted implant placementPreoperative planned implant positionApical deviation (mm)
Completely edentulous
MEAN 0.72 [0.58, 0.86]
GRADE not reported
6 studies
Patients receiving dental implants (Completely edentulous)Robot-assisted implant placementPreoperative planned implant positionCoronal deviation (mm)
Completely edentulous
MEAN 0.7 [0.55, 0.86]
GRADE not reported
6 studies
Patients receiving dental implants (Maxilla)Robot-assisted implant placementPreoperative planned implant positionAngular deviation (degrees)
Maxilla
MEAN 1.39 [1.06, 1.72]
GRADE not reported
10 studies
Patients receiving robot-placed implants in the maxillaRobot-assisted computer-aided implant surgery (r-CAIS), any systemPreoperative virtual implant plan (single-arm accuracy; no comparator group)Global apical deviation (mm)
Postoperative (placed versus planned implant position) · Clinical studies, mostly university hospitals and educational centers in China · Dental arch: Maxilla
MEAN 0.63 [0.54, 0.72]
GRADE not reported
10 studies
Patients receiving dental implants (Maxilla)Robot-assisted implant placementPreoperative planned implant positionCoronal deviation (mm)
Maxilla
MEAN 0.6 [0.52, 0.68]
GRADE not reported
10 studies
Patients receiving dental implants (Mandible)Robot-assisted implant placementPreoperative planned implant positionAngular deviation (degrees)
Mandible
MEAN 1.32 [0.98, 1.65]
GRADE not reported
8 studies
Patients receiving dental implants (Mandible)Robot-assisted implant placementPreoperative planned implant positionApical deviation (mm)
Mandible
MEAN 0.69 [0.54, 0.85]
GRADE not reported
8 studies
Patients receiving dental implants (Mandible)Robot-assisted implant placementPreoperative planned implant positionCoronal deviation (mm)
Mandible
MEAN 0.64 [0.51, 0.77]
GRADE not reported
8 studies
Patients receiving dental implants (Anterior)Robot-assisted implant placementPreoperative planned implant positionCoronal deviation (mm)
Anterior
MEAN 0.63 [0.55, 0.72]
GRADE not reported
10 studies
Patients receiving dental implants (Anterior)Robot-assisted implant placementPreoperative planned implant positionAngular deviation (degrees)
Anterior
MEAN 1.16 [0.9, 1.42]
GRADE not reported
10 studies
Patients receiving dental implants (Anterior)Robot-assisted implant placementPreoperative planned implant positionApical deviation (mm)
Anterior
MEAN 0.68 [0.58, 0.79]
GRADE not reported
10 studies
Patients receiving dental implants (Posterior)Robot-assisted implant placementPreoperative planned implant positionCoronal deviation (mm)
Posterior
MEAN 0.65 [0.54, 0.76]
GRADE not reported
9 studies
Patients receiving dental implants (Posterior)Robot-assisted implant placementPreoperative planned implant positionApical deviation (mm)
Posterior
MEAN 0.7 [0.57, 0.84]
GRADE not reported
9 studies
Patients receiving dental implants (Posterior)Robot-assisted implant placementPreoperative planned implant positionAngular deviation (degrees)
Posterior
MEAN 1.52 [1.01, 2.02]
GRADE not reported
9 studies
Patients receiving dental implantsYakebot robot-assisted implant placementPreoperative planned implant positionApical deviation (mm)
Robotic platform: Yakebot
MEAN 0.62 [0.56, 0.67]
GRADE not reported
11 studies
Patients receiving dental implantsYakebot robot-assisted implant placementPreoperative planned implant positionAngular deviation (degrees)
Robotic platform: Yakebot
MEAN 1.36 [1.13, 1.59]
GRADE not reported
11 studies
Patients receiving dental implantsYakebot robot-assisted implant placementPreoperative planned implant positionCoronal deviation (mm)
Robotic platform: Yakebot
MEAN 0.58 [0.52, 0.63]
GRADE not reported
11 studies
Patients receiving dental implantsRemebot robot-assisted implant placementPreoperative planned implant positionCoronal deviation (mm)
Robotic platform: Remebot
MEAN 0.64 [0.58, 0.7]
GRADE not reported
16 studies
Patients receiving dental implantsRemebot robot-assisted implant placementPreoperative planned implant positionApical deviation (mm)
Robotic platform: Remebot
MEAN 0.66 [0.59, 0.73]
GRADE not reported
16 studies
Patients receiving dental implantsRemebot robot-assisted implant placementPreoperative planned implant positionAngular deviation (degrees)
Robotic platform: Remebot
MEAN 1.3 [1.15, 1.44]
GRADE not reported
16 studies
Patients receiving dental implantsTheta robot-assisted implant placementPreoperative planned implant positionApical deviation (mm)
Robotic platform: Theta
MEAN 0.98 [0.8, 1.17]
GRADE not reported
6 studies
Patients receiving dental implantsTheta robot-assisted implant placementPreoperative planned implant positionCoronal deviation (mm)
Robotic platform: Theta
MEAN 0.87 [0.74, 1.0]
GRADE not reported
6 studies
Patients receiving dental implants placed with robotic assistanceYomi r-CAIS (haptic)Preoperative virtual implant plan (single-arm accuracy; no comparator group)Angular deviation (degrees)
Postoperative (placed versus planned implant position) · Clinical studies, mostly university hospitals and educational centers in China · Robotic platform: Yomi
MEAN 2.05 [1.27, 2.83]
GRADE not reported
3 studies
Patients receiving dental implants placed with robotic assistanceYomi r-CAIS (haptic)Preoperative virtual implant plan (single-arm accuracy; no comparator group)Global coronal deviation (mm)
Postoperative (placed versus planned implant position) · Clinical studies, mostly university hospitals and educational centers in China · Robotic platform: Yomi
MEAN 1.11 [1.03, 1.18]
GRADE not reported
3 studies
Patients receiving dental implants placed with robotic assistanceYomi r-CAIS (haptic)Preoperative virtual implant plan (single-arm accuracy; no comparator group)Global apical deviation (mm)
Postoperative (placed versus planned implant position) · Clinical studies, mostly university hospitals and educational centers in China · Robotic platform: Yomi
MEAN 1.18 [0.86, 1.50]
GRADE not reported
3 studies
Patients receiving dental implantsTheta robot-assisted implant placementPreoperative planned implant positionAngular deviation (degrees)
Robotic platform: Theta
MEAN 2.61 [1.82, 3.4]
GRADE not reported
6 studies

Included primary studies 78

Open in Studies
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Accuracy of the Yakebot dental implant robotic system versus fully guided static computer-assisted implant surgery template in edentulous…
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The Accuracy of Autonomous Robotic Surgery vs. Dynamic Navigation in Implant Placement: An Open-Label, Double-Arm, Randomized Controlled…
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1977this review onlynot statednot extracted yet
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Accuracy of an autonomous dental implant robotic system in dental implant surgery.
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A calcium-dependent protein activator of guanosine 3':5'-monophosphate phosphodiesterase in bovine and rat pancreas. Isolation, properties…
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1977this review onlynot statednot extracted yet
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2023this review onlynot statednot extracted yet
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2025this review onlynot statednot extracted yet
Yang 2025
A fully digital approach to autonomous robot-assisted immediate implant and interim restoration placement in the maxillary anterior…
PMID:40903322
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Yang et al., 2023
The operation of the malate-aspartate shuttle in the reoxidation of glycolytic NADH in slices of fetal rat liver.
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1977this review onlynot statednot extracted yet
Yang et al., 2024
Fate of histone messenger RNA in mengovirus-infected Ehrlich ascites tumor cells.
PMID:202458
1977this review onlynot statednot extracted yet
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[Contractile responses of the guinea pig ileal longitudinal muscle to antispasmodics (author's transl)].
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1977this review onlynot statednot extracted yet
Yang et al., 2025
Cadmium: a sombre picture.
PMID:202548
1977this review onlynot statednot extracted yet
Yang et al., 2025
Non-functioning islet cell tumours of the pancreas: a review of radiological literature and a report on two cases.
PMID:202549
1977this review onlynot statednot extracted yet
Younis 2025
Accuracy of robot-assisted implant surgery versus freehand placement: a retrospective clinical study.
PMID:39751717
2025this review onlynot statednot extracted yet
Yu 2024
A Comparative Prospective Study on the Accuracy and Efficiency of Autonomous Robotic System Versus Dynamic Navigation System in Dental…
PMID:39623953
2025this review onlynot statednot extracted yet
Zhao 2025
Application of a semi-active robotic system for implant placement in atrophic posterior maxilla: A retrospective case series.
PMID:39875023
2025this review onlynot statednot extracted yet
Zhao et al., 2025
An attempt to differentiate selection and amplification in hormone receptor development: the unicellular model.
PMID:202532
1977this review onlynot statednot extracted yet
Zhou 2025
Accuracy of Anterior Immediate Versus Delayed Implant Placement With an Autonomous Robotic System: A Retrospective Study.
PMID:40304442
2025this review onlynot statednot extracted yet
Zhou et al., 2025
[Oncological after-care in general practice].
PMID:202551
1978this review onlynot statednot extracted yet

Overlap with other reviews

Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.

ReviewShared studiesJaccard
Robotic Surgical Systems in Oral and Maxillofacial Surgery: A Systematic Review and Meta-Analysis. (2025)100.10
Comparison of dental implant placement accuracy between robotic and static or dynamic computer-assisted surgeries: A systematic review and… (2026)50.05
Accuracy of Static, Dynamic, and Robotic Guided Surgery in Immediate Implant Placement: A Systematic Review and Network Meta-Analysis. (2026)50.05
Robotic Computer-Assisted Dental Implant Surgery Versus Free-Hand and Guided Techniques: A Systematic Review and Meta-Analysis of… (2026)50.06
Grading the evidence for the association between periodontal disease and chronic non-communicable diseases: an umbrella review of… (2026)40.03
From Polyethylene Terephthalate Glycol (PETG) to 3D-Printed Resins: A Systematic Review and Meta-Analysis of Clear Aligner Material… (2026)30.03
The association of fluoride exposure with bone density and fracture risk: a dose-response meta-analysis. (2025)20.01
Systematic review and meta-analysis of oral frailty prevalence among older hospitalized patients. (2025)20.02
Is There an Association Between Periodontitis and Gestational Diabetes? A Systematic Review and Meta-Analysis. (2026)20.02
Accessory Mandibular Foramina: An Anatomical Study in Dry Mandibles and Meta-Analysis. (2026)20.01
Impact of Mobile Oral Health Applications on Pediatric Dental Anxiety: A Systematic Review and Network Meta-Analysis. (2026)20.02
Genetic Variants and Dental Caries Susceptibility: An Umbrella Review and Multilevel Meta-Analysis. (2026)20.01
Methods of incisor inclination control during the non-accelerated retraction of upper anterior teeth with fixed orthodontic appliances: a… (2026)20.02
Immigration detention of children: a systematic review and meta-analysis of physical and mental health impacts. (2026)10.01
Effect of intraarticular drug injection in patients with temporomandibular joint disorders with limited mouth opening: a system review and… (2025)10.01
Diagnostic, predictive, and therapeutic approaches for impacted canines: a systematic review and meta-analysis. (2026)10.01
Do Adjunctive Therapies with Natural Products Improve Periodontal Clinical Parameters After Non-Surgical Treatment? A Systematic Review… (2026)10.00
Prognostic value of NLR versus PLR and LMR in patients with oral squamous cell carcinoma: a meta-analysis. (2026)10.01
Neural biomarkers in pulpitis and their associations with inflammation and pain perception: a systematic review and meta-analysis. (2026)10.01
Resonance Frequency Analysis and Clinical Outcomes in Implant Dentistry: A Systematic Review and Meta-Analysis. (2026)10.01
Evaluation of dose-response relationships between smoking tobacco, alcohol consumption and oral cancer: a systematic review and… (2026)10.01
Efficacy of diode Laser compared to conventional irrigation in endodontic treatment of apical periodontitis: a systematic review and… (2026)10.01
Long-term Outcomes of Invasive Pulp Therapies in Primary Teeth: A Systematic Review and Meta-analysis. (2026)10.01
Efficacy of adjunctive antibiotics compared to non-antibiotic therapies following mechanical debridement for peri-implantitis: A… (2026)10.01
Analysis of Antibiotic Resistance Patterns and Distribution of Staphylococcus aureus in the Middle East: A Systematic Review and… (2026)10.00

Review question

ElementPlanned (methods)Found (results)
PopulationPatients undergoing dental implant placement with robotic assistance; studies with at least 10 implants or 5 patients1227 patients and 2066 implants (n=39); single, partially and completely edentulous cases; maxillary and mandibular, anterior and posterior sites
InterventionRobot-assisted computer-aided implant surgery (r-CAIS) with task-autonomous, semi-autonomous or haptic robotic systemsr-CAIS: task-autonomous Yakebot or FZ-DISAS-I (n=12), semi-autonomous Theta, Remebot, Dencore or Langyue (n=24), haptic Yomi (n=3)
ComparisonPreoperative planned implant position and, where applicable, conventional static or dynamic CAISPreoperative planned implant position (single-arm meta-analysis; no pooled comparison with conventional CAIS) (n=39)
OutcomesImplant placement accuracy: global coronal deviation (mm), global apical deviation (mm) and angular deviation (degrees)Global coronal deviation (n=39); global apical deviation (n=39); angular deviation (n=39)
Study designsRCTs, cohort studies, case series and clinical studies in peer-reviewed English-language journals, January 2015 to September 2025; in vitro, animal, review, case report and conference abstract excluded5 RCTs, 21 non-randomized controlled studies and 13 case series (n=39)
TimingNot specifiedNot specified

AMSTAR 2 items

Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.

ItemExtractor AExtractor BAgree
1Research question includes PICO componentsYesYesyes
2Protocol established before the reviewcriticalPartial YesPartial Yesyes
3Choice of study designs explainedNoNoyes
4Comprehensive literature searchcriticalNoPartial Yesno
5Study selection in duplicateYesYesyes
6Data extraction in duplicateYesNono
7List of excluded studies with reasonscriticalNoNoyes
8Included studies described in detailPartial YesPartial Yesyes
9Risk of bias assessed satisfactorilycriticalRCT: Yes · NRSI: YesNRSI: Yes · RCT: Yesno
10Funding of included studies reportedNoNoyes
11Appropriate meta-analysis methodscriticalRCT: Yes · NRSI: YesNRSI: No · RCT: Nono
12Impact of risk of bias on the pooled resultsNoNoyes
13Risk of bias accounted for in interpretationcriticalYesNono
14Heterogeneity explainedYesYesyes
15Publication bias investigatedcriticalNoNoyes
16Conflicts of interest reportedYesYesyes
OverallCritically LowCritically Lowyes