Non-Cochrane · prognostic · PM41458429
Systematic review and meta-analysis of oral frailty prevalence among older hospitalized patients.
Gong Jie, Tan Liping, Yan Jing, et al. · Frontiers in public health · 2025 · PubMed · doi:10.3389/fpubh.2025.1681594
Findings
Population Hospitalized patients
22 findings
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Meta-regression of prevalence on disease type Hospital inpatients · Meta-regression predictor: Disease type | Meta-regression coefficient -0.029 [-0.056, -0.002] GRADE not reported 27 studies · 11575 participants |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Prevalence of oral frailty Hospital inpatients · Overall | Prevalence 0.51 [0.47, 0.55] GRADE not reported 27 studies · 11575 participants |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Prevalence of oral frailty Hospital inpatients · Disease type: cancer | Prevalence 0.62 [0.57, 0.66] GRADE not reported 3 studies |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Meta-regression of prevalence on age group Hospital inpatients · Meta-regression predictor: Age group | Meta-regression coefficient 0.023 [-0.068, 0.113] GRADE not reported 27 studies · 11575 participants |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Prevalence of oral frailty Hospital inpatients · Disease type: neurological diseases | Prevalence 0.51 [0.41, 0.61] GRADE not reported 6 studies |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Prevalence of oral frailty Hospital inpatients · Study design: cohort | Prevalence 0.42 [0.36, 0.48] GRADE not reported 4 studies |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Prevalence of oral frailty Hospital inpatients · Sensitivity: cohort studies only, leave-one-out | Excluding any single study gave estimated prevalence ranging from 0.41 to 0.46 GRADE not reported 4 studies |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Prevalence of oral frailty Hospital inpatients · Sample size: <=500 | Prevalence 0.50 [0.44, 0.56] GRADE not reported 19 studies |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Prevalence of oral frailty Hospital inpatients · Study design: cross-sectional | Prevalence 0.52 [0.48, 0.57] GRADE not reported 23 studies |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Meta-regression of prevalence on study design Hospital inpatients · Meta-regression predictor: Study design | Meta-regression coefficient 0.114 [-0.008, 0.235] GRADE not reported 27 studies · 11575 participants |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Prevalence of oral frailty Hospital inpatients · Region: other regions | Prevalence 0.45 [0.37, 0.53] GRADE not reported 5 studies |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Prevalence of oral frailty Hospital inpatients · Disease type: diabetes | Prevalence 0.42 [0.32, 0.51] GRADE not reported 3 studies |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Meta-regression of prevalence on country Hospital inpatients · Meta-regression predictor: Country | Meta-regression coefficient -0.069 [-0.186, 0.048] GRADE not reported 27 studies · 11575 participants |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Prevalence of oral frailty Hospital inpatients · Age group: mixed ages | Prevalence 0.50 [0.43, 0.56] GRADE not reported 13 studies |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Prevalence of oral frailty Hospital inpatients · Disease type: surgical patients | Prevalence 0.48 [0.42, 0.53] GRADE not reported 3 studies |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Meta-regression of prevalence on sample size Hospital inpatients · Meta-regression predictor: Sample size | Meta-regression coefficient -0.022 [-0.120, 0.075] GRADE not reported 27 studies · 11575 participants |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Prevalence of oral frailty Hospital inpatients · Age group: >=60 years | Prevalence 0.52 [0.47, 0.57] GRADE not reported 14 studies |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Prevalence of oral frailty Hospital inpatients · Region: Mainland China | Prevalence 0.52 [0.48, 0.56] GRADE not reported 22 studies |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Prevalence of oral frailty Hospital inpatients · Disease type: chronic diseases | Prevalence 0.54 [0.49, 0.60] GRADE not reported 8 studies |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Prevalence of oral frailty Hospital inpatients · Disease type: renal diseases | Prevalence 0.39 [0.32, 0.47] GRADE not reported 3 studies |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Prevalence of oral frailty Hospital inpatients · Sensitivity: overall, leave-one-out Unresolved: the two extractors disagree on this row. | Sequentially removing each study left the overall prevalence statistically consistent with 0.51 GRADE not reported 26 studies |
| Oral frailty (condition of interest; no intervention) | None (single-group prevalence) | Prevalence of oral frailty Hospital inpatients · Sample size: >500 | Prevalence 0.52 [0.47, 0.57] GRADE not reported 8 studies |
Included primary studies 36
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Lu et al. 2025 DOI:10.19749/j.cn.cjgd.1672-2973.2025.03.009 | NR | 2 other reviews | Prevalence of oral frailty | not extracted yet |
| Luo et al. 2025 Influencing factors of oral frailty in elderly patients with type 2 diabetes in China: a cross-sectional study based on the integral model… DOI:10.1186/s12903-025-05815-8 | 2025 | 2 other reviews | Prevalence of oral frailty | not extracted yet |
| Shao et al. 2025 Central sites of action of gastrointestinal drugs. PMID:202539 | 1978 | 2 other reviews | not stated | not extracted yet |
| Tian et al. 2025 Analysis of the current status and influencing factors of oral frailty in elderly patients with type 2 diabetes mellitus in Taiyuan, China DOI:10.1186/s12877-025-06052-y | 2025 | 2 other reviews | Prevalence of oral frailty | not extracted yet |
| Chen et al. 2024 The current status and influencing factors of oral frailty in elderly maintenance hemodialysis patients based on the Andersen Oral Health… DOI:10.1186/s12903-024-04872-9 | 2024 | 1 other review | Prevalence of oral frailty | not extracted yet |
| Fan et al. 2024 DOI:10.3969/j.issn.1002-1256.2024.18.020 | NR | 1 other review | Prevalence of oral frailty | not extracted yet |
| Li et al. 2024 DOI:10.3870/j.issn.1001-4152.2024.03.049 | NR | 1 other review | Prevalence of oral frailty | not extracted yet |
| Li et al. 2025 Oral frailty and its influencing factors in patients with cancer undergoing chemotherapy: a cross-sectional study DOI:10.1186/s12903-025-05789-7 | 2025 | 1 other review | Prevalence of oral frailty | not extracted yet |
| Li et al. 2025 [Normal development of gestation with term delivery of a healthy offspring following surgery for stomach and ovarian neoplasms treated… PMID:202544 | 1977 | 1 other review | not stated | not extracted yet |
| Lu et al. 2025 The estimation and characterisation of concanavalin A receptors on the surface of normal and SV-40 transformed 3T3 fibroblasts using the… PMID:202523 | 1978 | 1 other review | not stated | not extracted yet |
| Ma et al. 2025 Development and validation of risk-predicting model for oral frailty in older adults patients with stroke DOI:10.1186/s12903-025-05428-1 | 2025 | 1 other review | Prevalence of oral frailty | not extracted yet |
| Wu et al. 2024 DOI:10.13799/j.cnki.mdjyxyxb.2024.02.034 | NR | 1 other review | Prevalence of oral frailty | not extracted yet |
| Chen et al. 2023 Tongue pressure during swallowing is an independent risk factor for aspiration pneumonia in middle‐aged and older hospitalized patients:… DOI:10.1111/ggi.14769 | 2023 | this review only | Prevalence of oral frailty | not extracted yet |
| Chen et al. 2024 The relationship between oral frailty and oral dysbiosis among hospitalized patients aged older than 50 years DOI:10.1002/cre2.890 | 2024 | this review only | Prevalence of oral frailty | not extracted yet |
| Dou et al. 2025 Prevalence and associated factors with oral frailty in middle-aged and older hospitalized patients: a cross-sectional study DOI:10.3389/fpubh.2025.1446862 | 2025 | this review only | Prevalence of oral frailty | not extracted yet |
| Hu et al. 2024 Associations between oral frailty, oral microbiota composition, and postoperative delirium in older adult patients DOI:10.1111/jgs.19315 | 2024 | this review only | Prevalence of oral frailty | not extracted yet |
| Hu et al. 2024 DOI:10.12102/j.issn.2095-8668.2024.20.023 | NR | this review only | Prevalence of oral frailty | not extracted yet |
| Hu et al. 2024 [Histochemical and quantitative methods in the biopsy examination of skeletal muscles]. PMID:202410 | 1977 | this review only | not stated | not extracted yet |
| Ikuno et al. 2024 Effect of Oral Frailty on Postoperative Infection in Patients Undergoing Abdominal Visceral Surgery DOI:10.1111/odi.15162 | 2024 | this review only | Prevalence of oral frailty | not extracted yet |
| Kobayashi et al. 2025 Association of Oral Frailty with Physical Frailty and Malnutrition in Patients on Peritoneal Dialysis DOI:10.3390/nu17121950 | 2025 | this review only | Prevalence of oral frailty | not extracted yet |
| Li et al. 2024 DOI:10.13799/j.cnki.mdjyxyxb.2024.06.015 | NR | this review only | Prevalence of oral frailty | not extracted yet |
| Li et al. 2024 DOI:10.3969/j.issn.1002-1256.2024.17.016 | NR | this review only | Prevalence of oral frailty | not extracted yet |
| Li et al. 2024 Patterns of cyclic 3'5'-adenosine monophosphate excretion in parathyroid dysfunction. PMID:202439 | 1977 | this review only | not stated | not extracted yet |
| Li et al. 2025 DOI:10.3969/j.issn.1002-0217.2025.01.016 | NR | this review only | Prevalence of oral frailty | not extracted yet |
| Miyasato et al. 2024 Oral Frailty as a Risk Factor for Malnutrition and Sarcopenia in Patients on Hemodialysis: A Prospective Cohort Study DOI:10.3390/nu16203467 | 2024 | this review only | Prevalence of oral frailty | not extracted yet |
| Shang et al. 2025 DOI:10.3760/cma.j.cn115682-20240723-04121 | NR | this review only | Prevalence of oral frailty | not extracted yet |
| Shang et al. 2025 Gangliosides of active and inactive neuroblastoma clones. PMID:202531 | 1977 | this review only | not stated | not extracted yet |
| Shao et al. 2025 matched by author and year (probable) | NR | this review only | Prevalence of oral frailty | not extracted yet |
| Shi et al. 2025 DOI:10.3760/cma.j.cn115682-20240930-05423 | NR | this review only | Prevalence of oral frailty | not extracted yet |
| Wang et al. 2025 DOI:10.12114/j.issn.1008-5971.2025.00.105 | NR | this review only | Prevalence of oral frailty | not extracted yet |
| Wang et al. 2025 DOI:10.16440/j.cnki.1674-8166.2025.01.05 | NR | this review only | Prevalence of oral frailty | not extracted yet |
| Wang et al. 2025 Effect of androgens on the biosynthesis of estradiol-17beta by isolated periovulatory rat follicles. PMID:202526 | 1977 | this review only | not stated | not extracted yet |
| Wang et al. 2025 Immunosupressive activity of the basic protein from tumor tissue. PMID:202533 | 1977 | this review only | not stated | not extracted yet |
| Wu et al. 2024 [Recognition and delineation of frequent peripheral nerve injuries]. PMID:202445 | 1978 | this review only | not stated | not extracted yet |
| Xie et al. 2024 Association of oral frailty and gait characteristics in patients with cerebral small vessel disease DOI:10.1186/s12883-024-03848-0 | 2024 | this review only | Prevalence of oral frailty | not extracted yet |
| Yang et al. 2024 Oral Health and Its Associated Factors Among the Elderly in the Emergency Department: A Latent Class Analysis DOI:10.2147/jmdh.s469086 | 2024 | this review only | Prevalence of oral frailty | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Hospitalized patients or patients requiring regular hospital admission (e.g., hemodialysis, radiotherapy, chemotherapy); excluded outpatients, nursing facility residents, patients with dental disease, stays under 3 days | Hospitalized patients (n=11575) in 27 studies, mostly in China (22 studies) |
| Intervention | Not applicable (prevalence review) | Not applicable (prevalence review) |
| Comparison | Not applicable (prevalence review) | Not applicable (prevalence review) |
| Outcomes | Prevalence of oral frailty measured by a validated or reliable tool | Pooled prevalence of oral frailty 51% (95% CI 47-55%), I2 94.35% |
| Study designs | Cross-sectional or cohort studies; English or Chinese | 23 cross-sectional and 4 cohort studies |
| Timing | Not specified | Not specified |