Non-Cochrane · intervention · PM42291286
Efficacy of diode Laser compared to conventional irrigation in endodontic treatment of apical periodontitis: a systematic review and meta-analysis.
Casaretto-Gamonal Mario G, Moreno-Prieto Victor, Murillo-Almache Angela M, et al. · Frontiers in oral health · 2026 · PubMed · doi:10.3389/froh.2026.1814056
Findings
Population Patients with apical periodontitis undergoing non-surgical endodontic treatment
5 findings
| Diode laser-assisted irrigation | Conventional irrigation without laser | Postoperative pain (VAS), 2 days 2 days after treatment | MD 0.05 [-1.19, 1.28] 0.05 [-1.19, 1.28] Very low Downgraded: risk of bias, inconsistency 4 studies · 213 participants |
| Diode laser-assisted irrigation | Conventional irrigation without laser | Postoperative pain (VAS), 14 days 14 days after treatment | MD -0.18 [-0.39, 0.02] -0.18 [-0.39, 0.02] Low Downgraded: risk of bias 3 studies · 120 participants |
| Diode laser-assisted irrigation | Conventional irrigation without laser | Postoperative pain (VAS), 7 days 7 days after treatment | MD -0.61 [-0.90, -0.32] -0.61 [-0.90, -0.32] Low Downgraded: risk of bias 5 studies · 193 participants |
| Diode laser-assisted irrigation | Conventional irrigation without laser | Postoperative pain (VAS), 3 days 3 days after treatment | MD -0.64 [-1.63, 0.36] -0.64 [-1.63, 0.36] Very low Downgraded: risk of bias, inconsistency 5 studies · 253 participants |
| Diode laser-assisted irrigation | Conventional irrigation without laser | Postoperative pain (VAS), 1 day 1 day after treatment | MD -0.74 [-2.17, 0.70] -0.74 [-2.17, 0.70] Very low Downgraded: risk of bias, imprecision, inconsistency 5 studies · 260 participants |
Included primary studies 15
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Fahim 2024 Effects of renal dopamine receptor and beta-adrenoreceptor blockade on rises in blood angiotensin after haemorrhage, renal ischaemia and… PMID:202430 | 1978 | 4 other reviews | not stated | not extracted yet |
| Abbara 2023 The action of melatonin on single amphibian pigment cells in tissue culture. PMID:202360 | 1977 | 1 other review | not stated | not extracted yet |
| Abbara 2024 Can diode laser 810 nm decrease post endodontic pain in patients with asymptomatic necrotic maxillary incisors? A four-arm randomized… DOI:10.1038/s41405-024-00203-w | 2024 | this review only | not stated | not extracted yet |
| Abielhassan 2021 DOI:10.37506/ijphrd.v12i3.15934 | NR | this review only | not stated | not extracted yet |
| Arslan 2017 Effect of Low-level Laser Therapy on Postoperative Pain after Root Canal Retreatment: A Preliminary Placebo-controlled, Triple-blind,… DOI:10.1016/j.joen.2017.06.028 | 2017 | this review only | not stated | not extracted yet |
| Ismail 2023 Efficiency of diode laser in control of post-endodontic pain: a randomized controlled trial DOI:10.1007/s00784-023-04864-z | 2023 | this review only | not stated | not extracted yet |
| Kaplan 2022 The effect of different irrigation and disinfection methods on post-operative pain in mandibular molars: a randomised clinical trial DOI:10.1186/s12903-022-02651-y | 2022 | this review only | not stated | not extracted yet |
| Maheshwari 2024 DOI:10.53555/jptcp.v31i5.6103 | NR | this review only | not stated | not extracted yet |
| Morsy 2018 Postoperative pain and antibacterial effect of 980 nm diode laser versus conventional endodontic treatment in necrotic teeth with chronic… DOI:10.12688/f1000research.16794.1 | 2018 | this review only | not stated | not extracted yet |
| Noferesti 2024 Impact of Photobiomodulation and Melatonin on Periodontal Healing of Periodontitis in Immunosuppressed Rats. PMID:39193106 | 2024 | this review only | not stated | not extracted yet |
| Noferesti 2024 A 980 nm Diode Laser as an Adjunctive Therapy on the Healing of Apical Periodontitis Following Endodontic Retreatment: A Randomized… PMID:39193108 | 2024 | this review only | not stated | not extracted yet |
| Shah 2022 Evaluation of Effect of Low Level Laser Therapy with Intracanal Medicament on Periapical Healing DOI:10.4103/ijdr.ijdr_896_20 | 2021 | this review only | not stated | not extracted yet |
| Shivangi 2023 Comparison of postoperative pain using two instrumentation techniques followed by laser irradiation in nonvital teeth with symptomatic… DOI:10.4103/endo.endo_125_22 | 2023 | this review only | not stated | not extracted yet |
| Tamer 2023 The effect of the irrigant activation protocol on postoperative pain in maxillary incisors with asymptomatic apical periodontitis: A… DOI:10.1002/cre2.786 | 2023 | this review only | not stated | not extracted yet |
| Zakaria 2024 The efficacy of 2780 nm Er,Cr;YSGG and 940 nm Diode Laser in root canal disinfection: A randomized clinical trial DOI:10.1007/s00784-024-05563-z | 2024 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults with symptomatic or asymptomatic apical periodontitis undergoing non-surgical endodontic treatment | Patients with apical periodontitis, 18 to 65 years (n=863 across 12 RCTs) |
| Intervention | Diode laser-assisted irrigation (alone or with NaOCl or EDTA) | Diode laser (660 to 980 nm; laser-activated irrigation, photodynamic therapy, low-level laser therapy) |
| Comparison | Conventional irrigation (manual or sonic/ultrasonic activation) without laser | Conventional irrigation including ultrasonic, sonic, XP-Endo Finisher, calcium hydroxide, placebo laser |
| Outcomes | Bacterial reduction, postoperative pain, radiographic healing; adverse events and procedural complications | Postoperative pain at 1, 2, 3, 7 and 14 days (pooled, 3 to 5 RCTs); bacterial load, radiographic healing, adverse events (narrative) |
| Study designs | Parallel-group RCTs | RCTs (n=12) |
| Timing | Not specified | 72 hours to 12 months |