Cochrane Review Group

Neuromuscular

89 systematic reviews in Neuromuscular ask 1,173 questions. 25.7% have no studies to answer them, 22.8% rest on very low certainty evidence and 21% reach moderate or high certainty.

Reviews

Questions

1,173

current versions

No studies

25.7%

Moderate or high

21%

No studies 302 · 25.7%Ungraded 119 · 10.1%Very low 267 · 22.8%Low 239 · 20.4%Moderate 177 · 15.1%High 69 · 5.9%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Search questions in Neuromuscular

Thinnest evidence

All no studies and very low questions

Question	Effect	Evidence	Status / GRADE
Surgery vs corticosteroid injection Health‐related quality of life ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	no estimate extracted	NR	No studies
Surgery vs corticosteroid injection Adverse effects · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	RR 1.49 [0.25, 8.7]	2 studies · 90 participants	Very low
Surgery vs corticosteroid injection Need for surgery or secondary surgery during · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	RR 0.61 [0.25, 1.46]	1 study · 163 participants	Very low
Surgery vs splint Pain ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	no estimate extracted	NR	No studies
Surgery vs splint Adverse effects · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	RR 2.11 [0.37, 12.12]	2 studies · 210 participants	Very low
Surgery vs corticosteroid injection Clinical improvement ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	RR 1.23 [0.73, 2.06]	3 studies · 187 participants	Very low
Surgery vs corticosteroid injection Symptoms ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	no estimate extracted	2 studies · 118 participants	Very low
Intravenous immunoglobulin vs prednisolone Change in mean disability score at 24 weeks or later · patients with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane	no estimate extracted	NR	No studies
Intravenous immunoglobulin vs plasma exchange Significant improvement in disability within 6 weeks · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane	no estimate extracted	NR	No studies
Intravenous immunoglobulin vs plasma exchange Change in mean disability score on Rankin scale · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane	no estimate extracted	NR	No studies
Intravenous immunoglobulin vs plasma exchange Change in mean disability score at 24 weeks or later · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane	no estimate extracted	NR	No studies
Alpha‐lipoic acid vs placebo Change in any validated quality of life score · people with DPN Alpha‐lipoic acid for diabetic peripheral neuropathy (2024) · Cochrane	no estimate extracted	NR	No studies

Reviews 89

Acetyl‐L‐carnitine for the treatment of diabetic peripheral neuropathy

Rolim, LCSP, da Silva, EMK, et al. · Cochrane Database of Systematic Reviews · 2019

Neuromuscular

Thinnest evidence

Reviews 89

Acetyl‐L‐carnitine for the treatment of diabetic peripheral neuropathy

Respiratory muscle training in children and adults with neuromuscular disease

Cell‐based therapies for amyotrophic lateral sclerosis/motor neuron disease

Physical exercise training for type 3 spinal muscular atrophy

Interventions for idiopathic toe walking

Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked dilated cardiomyopathy

Acupuncture for symptomatic gastroparesis

Treatment of fatigue in amyotrophic lateral sclerosis/motor neuron disease

Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome

Absorbable versus non‐absorbable sutures for skin closure after carpal tunnel decompression surgery

Plasma exchange for Guillain‐Barré syndrome

Corticosteroids for chronic inflammatory demyelinating polyradiculoneuropathy

Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory demyelinating polyradiculoneuropathy

Tramadol for neuropathic pain in adults

Mechanical ventilation for amyotrophic lateral sclerosis/motor neuron disease

Gamma aminobutyric acid (GABA) modulators for amyotrophic lateral sclerosis/motor neuron disease

Oxcarbazepine for neuropathic pain

Low‐level laser therapy for carpal tunnel syndrome

Corticosteroids for Guillain‐Barré syndrome

Corticosteroids for Bell's palsy (idiopathic facial paralysis)

Immunotherapy for IgM anti‐myelin‐associated glycoprotein paraprotein‐associated peripheral neuropathies

Corticosteroids for the treatment of Duchenne muscular dystrophy

Rehabilitation following carpal tunnel release

Corticosteroids for treating nerve damage in leprosy

Treatment for ulnar neuropathy at the elbow