Cochrane · systematic review · CD012120
Physical exercise training for type 3 spinal muscular atrophy
Bartels, B, Montes, J, van der Pol, WL, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
NeuromuscularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
7
No studies
1
Included studies
NR
No studies 1 · 12.5%Ungraded 0 · 0%Very low 7 · 87.5%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Combined strength and aerobic exercise training compared to usual care in SMA type 3
Population: children and adults with SMA type 3
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Walking distance on the 6MWT (m) (a higher score indicates better function) Change from baseline Combined strength and aerobic exercise training vs usual care | no estimate extracted | 1 study · 12 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Cardiopulmonary exercise capacity Combined strength and aerobic exercise training vs usual care | no estimate extracted | 1 study · 12 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Functional performance Combined strength and aerobic exercise training vs usual care | no estimate extracted | 1 study · 12 participants | Very low Downgraded: risk of bias, imprecision |
Muscle strength (MMT total score) Combined strength and aerobic exercise training vs usual care | no estimate extracted | 1 study · 12 participants | Very low Downgraded: risk of bias, imprecision |
Fatigue In children, Combined strength and aerobic exercise training vs usual care | no estimate extracted | 1 study · 12 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Physical activity ‐ change from baseline Combined strength and aerobic exercise training vs usual care | no estimate extracted | NR | No studies |
Quality of life In children, Combined strength and aerobic exercise training vs usual care | no estimate extracted | 1 study · 12 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Serious adverse events leading to withdrawal Combined strength and aerobic exercise training vs usual care | no estimate extracted | 1 study · 12 participants | Very low Downgraded: risk of bias, imprecision, indirectness |