Cochrane Review Group

Neuromuscular

89 systematic reviews in Neuromuscular ask 1,173 questions. 25.7% have no studies to answer them, 22.8% rest on very low certainty evidence and 21% reach moderate or high certainty.

Reviews

Questions

1,173

current versions

No studies

25.7%

Moderate or high

21%

No studies 302 · 25.7%Ungraded 119 · 10.1%Very low 267 · 22.8%Low 239 · 20.4%Moderate 177 · 15.1%High 69 · 5.9%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Search questions in Neuromuscular

Thinnest evidence

All no studies and very low questions

Question	Effect	Evidence	Status / GRADE
Surgery vs corticosteroid injection Health‐related quality of life ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	no estimate extracted	NR	No studies
Surgery vs corticosteroid injection Adverse effects · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	RR 1.49 [0.25, 8.7]	2 studies · 90 participants	Very low
Surgery vs corticosteroid injection Need for surgery or secondary surgery during · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	RR 0.61 [0.25, 1.46]	1 study · 163 participants	Very low
Surgery vs splint Pain ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	no estimate extracted	NR	No studies
Surgery vs splint Adverse effects · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	RR 2.11 [0.37, 12.12]	2 studies · 210 participants	Very low
Surgery vs corticosteroid injection Clinical improvement ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	RR 1.23 [0.73, 2.06]	3 studies · 187 participants	Very low
Surgery vs corticosteroid injection Symptoms ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	no estimate extracted	2 studies · 118 participants	Very low
Intravenous immunoglobulin vs prednisolone Change in mean disability score at 24 weeks or later · patients with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane	no estimate extracted	NR	No studies
Intravenous immunoglobulin vs plasma exchange Significant improvement in disability within 6 weeks · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane	no estimate extracted	NR	No studies
Intravenous immunoglobulin vs plasma exchange Change in mean disability score on Rankin scale · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane	no estimate extracted	NR	No studies
Intravenous immunoglobulin vs plasma exchange Change in mean disability score at 24 weeks or later · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane	no estimate extracted	NR	No studies
Alpha‐lipoic acid vs placebo Change in any validated quality of life score · people with DPN Alpha‐lipoic acid for diabetic peripheral neuropathy (2024) · Cochrane	no estimate extracted	NR	No studies

Reviews 89

Surgical versus non‐surgical treatment for carpal tunnel syndrome

Lusa, V, Karjalainen, TV, et al. · Cochrane Database of Systematic Reviews · 2024

Neuromuscular

Thinnest evidence

Reviews 89

Surgical versus non‐surgical treatment for carpal tunnel syndrome

Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy

Alpha‐lipoic acid for diabetic peripheral neuropathy

Treatments for Morton's neuroma

Corticosteroids for preventing postherpetic neuralgia

Splinting for carpal tunnel syndrome

Local corticosteroid injection versus placebo for carpal tunnel syndrome

Immunoglobulin for multifocal motor neuropathy

Treatment for sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis

Bioengineered nerve conduits and wraps for peripheral nerve repair of the upper limb

Surgical interventions for the early management of Bell's palsy

Non‐drug therapies for the secondary prevention of lower limb muscle cramps

Fludrocortisone for orthostatic hypotension

Cough augmentation techniques for people with chronic neuromuscular disorders

Interventions for promoting physical activity in people with neuromuscular disease

Antioxidants to prevent respiratory decline in people with Duchenne muscular dystrophy and progressive respiratory decline

Drug treatment for spinal muscular atrophy types II and III

Interventions for congenital talipes equinovarus (clubfoot)

Pharmacological treatment other than corticosteroids, intravenous immunoglobulin and plasma exchange for Guillain‐Barré syndrome

Magnesium for skeletal muscle cramps

Pharmacological treatment for familial amyloid polyneuropathy

Antiviral treatment for Bell's palsy (idiopathic facial paralysis)

Strength training and aerobic exercise training for muscle disease

Drug treatment for spinal muscular atrophy type I

Medical treatment for botulism