Cochrane · systematic review · CD015148
Local corticosteroid injection versus placebo for carpal tunnel syndrome
Ashworth, NL, Bland, JD P, Chapman, KM, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
NeuromuscularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 1 · 14.3%Moderate 5 · 71.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Local corticosteroid injection (LCI) compared to saline no treatment or placebo for carpal tunnel syndrome
Population: people with carpal tunnel syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement in symptoms at ≤ 3 months Local corticosteroid injection (LCI) vs saline no treatment or placebo | no estimate extracted | 8 studies · 579 participants | Moderate Downgraded: imprecision |
Improvement in function at ≤ 3 months Local corticosteroid injection (LCI) vs saline no treatment or placebo | no estimate extracted | 7 studies · 499 participants | Moderate Downgraded: imprecision |
Improvement in symptoms at > 3 months Local corticosteroid injection (LCI) vs saline no treatment or placebo | no estimate extracted | 3 studies · 234 participants | Moderate Downgraded: imprecision |
Improvement in neurophysiological parameters at ≤ 3 months Local corticosteroid injection (LCI) vs saline no treatment or placebo | no estimate extracted | 6 studies · 359 participants | Very low Downgraded: imprecision, inconsistency |
Requirement for carpal tunnel surgery Local corticosteroid injection (LCI) vs saline no treatment or placebo | RR 0.84 [0.72, 0.98] | 1 study · 111 participants | Moderate Downgraded: imprecision |
Improvement in quality of life Local corticosteroid injection (LCI) vs saline no treatment or placebo | no estimate extracted | 1 study · 111 participants | Moderate Downgraded: imprecision |
Adverse events Local corticosteroid injection (LCI) vs saline no treatment or placebo | no estimate extracted | 9 studies · 639 participants | Low Downgraded: imprecision, inconsistency |