Cochrane Review Group

Neuromuscular

89 systematic reviews in Neuromuscular ask 1,173 questions. 25.7% have no studies to answer them, 22.8% rest on very low certainty evidence and 21% reach moderate or high certainty.

Reviews

Questions

1,173

current versions

No studies

25.7%

Moderate or high

21%

No studies 302 · 25.7%Ungraded 119 · 10.1%Very low 267 · 22.8%Low 239 · 20.4%Moderate 177 · 15.1%High 69 · 5.9%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Search questions in Neuromuscular

Thinnest evidence

All no studies and very low questions

Question	Effect	Evidence	Status / GRADE
Surgery vs corticosteroid injection Health‐related quality of life ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	no estimate extracted	NR	No studies
Surgery vs corticosteroid injection Adverse effects · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	RR 1.49 [0.25, 8.7]	2 studies · 90 participants	Very low
Surgery vs corticosteroid injection Need for surgery or secondary surgery during · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	RR 0.61 [0.25, 1.46]	1 study · 163 participants	Very low
Surgery vs splint Pain ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	no estimate extracted	NR	No studies
Surgery vs splint Adverse effects · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	RR 2.11 [0.37, 12.12]	2 studies · 210 participants	Very low
Surgery vs corticosteroid injection Clinical improvement ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	RR 1.23 [0.73, 2.06]	3 studies · 187 participants	Very low
Surgery vs corticosteroid injection Symptoms ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane	no estimate extracted	2 studies · 118 participants	Very low
Intravenous immunoglobulin vs prednisolone Change in mean disability score at 24 weeks or later · patients with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane	no estimate extracted	NR	No studies
Intravenous immunoglobulin vs plasma exchange Significant improvement in disability within 6 weeks · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane	no estimate extracted	NR	No studies
Intravenous immunoglobulin vs plasma exchange Change in mean disability score on Rankin scale · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane	no estimate extracted	NR	No studies
Intravenous immunoglobulin vs plasma exchange Change in mean disability score at 24 weeks or later · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane	no estimate extracted	NR	No studies
Alpha‐lipoic acid vs placebo Change in any validated quality of life score · people with DPN Alpha‐lipoic acid for diabetic peripheral neuropathy (2024) · Cochrane	no estimate extracted	NR	No studies

Reviews 89

Pharmacological treatments for Friedreich ataxia

Kearney, M, Orrell, RW, et al. · Cochrane Database of Systematic Reviews · 2016

Neuromuscular

Thinnest evidence

Reviews 89

Pharmacological treatments for Friedreich ataxia

Treatment for inclusion body myositis

Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy

Plasma exchange for chronic inflammatory demyelinating polyradiculoneuropathy

Quinine for muscle cramps

Treatment for IgG and IgA paraproteinaemic neuropathy

Treatment for postpolio syndrome

Pharmacological treatment for pain in Guillain‐Barré syndrome

Ascorbic acid for the treatment of Charcot‐Marie‐Tooth disease

Nocturnal mechanical ventilation for chronic hypoventilation in patients with neuromuscular and chest wall disorders

Intravenous immunoglobulin for Guillain‐Barré syndrome

Interventions for preventing critical illness polyneuropathy and critical illness myopathy

Antiviral treatment for preventing postherpetic neuralgia

Acetylcholinesterase inhibitor treatment for myasthenia gravis

Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia

Interventions for fatigue in peripheral neuropathy

Endoscopic release for carpal tunnel syndrome

Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes

Non‐antiepileptic drugs for trigeminal neuralgia

Creatine for treating muscle disorders

Therapeutic exercise for people with amyotrophic lateral sclerosis or motor neuron disease

Topiramate for neuropathic pain and fibromyalgia in adults

Repetitive transcranial magnetic stimulation for the treatment of amyotrophic lateral sclerosis or motor neuron disease

Therapeutic ultrasound for carpal tunnel syndrome

Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)