Cochrane · systematic review · CD007818
Treatment for postpolio syndrome
Koopman, FS, Beelen, A, Gilhus, NE, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
25
current version
GRADE rated
11
No studies
6
Included studies
NR
No studies 6 · 24%Ungraded 8 · 32%Very low 1 · 4%Low 7 · 28%Moderate 2 · 8%High 1 · 4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsIVIg versus placebo for postpolio syndrome
Population: people with postpolio syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
(Change in) Activity limitations ≤ 3 months IVIg vs placebo | no estimate extracted | 2 studies · 185 participants | Moderate Downgraded: risk of bias |
Activity limitations > 3 months IVIg vs placebo | no estimate extracted | 2 studies · 91 participants | Low Downgraded: risk of bias |
Adverse events IVIg vs placebo | no estimate extracted | 3 studies · 212 participants | Ungraded |
Modafinil versus placebo for postpolio syndrome
Population: people with postpolio syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Activity limitations Modafinil vs placebo | no estimate extracted | 1 study · 33 participants | High |
Adverse events Modafinil vs placebo | no estimate extracted | 2 studies · 50 participants | Ungraded |
Pyridostigmine versus placebo for postpolio syndrome
Population: people with postpolio syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in activity limitations Pyridostigmine vs placebo | no estimate extracted | 1 study · 124 participants | Moderate Downgraded: risk of bias |
Adverse events Pyridostigmine vs placebo | no estimate extracted | 2 studies · 193 participants | Ungraded |
Lamotrigine versus control for postpolio syndrome
Population: people with postpolio syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Activity limitations Lamotrigine vs control | no estimate extracted | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events Lamotrigine vs control | no estimate extracted | 1 study · 30 participants | Ungraded |
Amantadine versus placebo for postpolio syndrome
Population: people with postpolio syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Activity limitations ‐ not measured Amantadine vs placebo | no estimate extracted | NR | No studies |
Adverse events Amantadine vs placebo | no estimate extracted | 1 study · 25 participants | Ungraded |
Prednisone versus placebo for postpolio syndrome
Population: people with postpolio syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Activity limitations ‐ not measured Prednisone vs placebo | no estimate extracted | NR | No studies |
Adverse events Prednisone vs placebo | no estimate extracted | 1 study · 17 participants | Ungraded |
Muscle strengthening versus control for postpolio syndrome
Population: people with postpolio syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Activity limitations ‐ not measured Muscle strengthening vs control | no estimate extracted | NR | No studies |
Adverse events Muscle strengthening vs control | no estimate extracted | 1 study · 10 participants | Ungraded |
Rehabilitation in cold climate versus usual care for postpolio syndrome
Population: people with postpolio syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Activity limitations at 3 months Rehabilitation in cold climate vs usual care | no estimate extracted | 1 study · 53 participants | Low Downgraded: risk of bias |
Activity limitations at 6 months Rehabilitation in cold climate vs usual care | no estimate extracted | 1 study · 53 participants | Low Downgraded: risk of bias |
Activity limitations at 3 months Rehabilitation in cold climate vs usual care | no estimate extracted | 1 study · 53 participants | Low Downgraded: risk of bias |
Activity limitations at 6 months Rehabilitation in cold climate vs usual care | no estimate extracted | 1 study · 53 participants | Low Downgraded: risk of bias |
Adverse events ‐ not measured Rehabilitation in cold climate vs usual care | no estimate extracted | NR | No studies |
Rehabilitation in warm climate versus usual care for postpolio syndrome
Population: people with postpolio syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Activity limitations 3 months Rehabilitation in warm climate vs usual care | no estimate extracted | 1 study · 57 participants | Low Downgraded: risk of bias |
Activity limitations 3 months Rehabilitation in warm climate vs usual care | no estimate extracted | 1 study · 57 participants | Low Downgraded: risk of bias |
Adverse events ‐ not measured Rehabilitation in warm climate vs usual care | no estimate extracted | NR | No studies |
Static magnetic fields versus placebo for postpolio syndrome
Population: people with postpolio syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Activity limitations ‐ not measured Static magnetic fields vs placebo | no estimate extracted | NR | No studies |
Adverse events Static magnetic fields vs placebo | no estimate extracted | 1 study · 50 participants | Ungraded |