Cochrane · systematic review · CD011005
Treatment of fatigue in amyotrophic lateral sclerosis/motor neuron disease
Gibbons, C, Pagnini, F, Friede, T, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
NeuromuscularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 8 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Modafinil compared to placebo in ALS/MND
Population: people with ALS/MND
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fatigue Modafinil vs placebo | no estimate extracted | 1 study · 32 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events Modafinil vs placebo | no estimate extracted | 1 study · 32 participants | Very low Downgraded: risk of bias, imprecision |
Exercise compared to usual care in ALS/MND
Population: people with ALS/MND
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fatigue Exercise vs usual care | no estimate extracted | 1 study · 18 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events Exercise vs usual care | no estimate extracted | 1 study · 18 participants | Very low Downgraded: risk of bias, imprecision |
Inspiratory muscle training compared to sham intervention in ALS/MND
Population: people with ALS/MND
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fatigue Inspiratory muscle training vs sham intervention | no estimate extracted | 1 study · 24 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events Inspiratory muscle training vs sham intervention | no estimate extracted | 1 study · 24 participants | Very low Downgraded: risk of bias, imprecision |
Repetitive transcranial magnetic stimulation (rTMS) compared to sham intervention in ALS/MND
Population: people with ALS/MND
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fatigue Repetitive transcranial magnetic stimulation (rTMS) vs sham intervention | no estimate extracted | 1 study · 10 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events Repetitive transcranial magnetic stimulation (rTMS) vs sham intervention | no estimate extracted | 1 study · 10 participants | Very low Downgraded: risk of bias, imprecision |