Cochrane · systematic review · CD003726
Tramadol for neuropathic pain in adults
Duehmke, RM, Derry, S, Wiffen, PJ, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
NeuromuscularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 42.9%Low 4 · 57.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Tramadol compared with placebo for neuropathic pain
Population: adults with neuropathic pain (any origin)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
At least 30% reduction in pain Tramadol vs placebo | no estimate extracted | 2 studies · 157 participants | Low Downgraded: imprecision |
At least 50% reduction in pain Tramadol vs placebo | RR 2.2 [1.02, 4.6] | 3 studies · 265 participants | Low Downgraded: imprecision |
PGIC much or very much improved Tramadol vs placebo | no estimate extracted | 1 study · 35 participants | Very low Downgraded: imprecision |
Withdrawal due to adverse event Tramadol vs placebo | RR 4.1 [2, 8.4] | 6 studies · 485 participants | Low Downgraded: imprecision |
Participants experiencing any adverse event Tramadol vs placebo | RR 1.6 [1.2, 2.1] | 4 studies · 266 participants | Low Downgraded: imprecision |
Serious adverse events Tramadol vs placebo | no estimate extracted | NR | Very low Downgraded: imprecision |
Death Tramadol vs placebo | no estimate extracted | NR | Very low |