Cochrane Review Group

Musculoskeletal

143 systematic reviews in Musculoskeletal ask 1,956 questions. 28.4% have no studies to answer them, 13% rest on very low certainty evidence and 24.8% reach moderate or high certainty.

Reviews

143

Questions

1,956

current versions

No studies

28.4%

Moderate or high

24.8%

No studies 555 · 28.4%Ungraded 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Search questions in Musculoskeletal

Thinnest evidence

All no studies and very low questions

Question	Effect	Evidence	Status / GRADE
Methotrexate vs placebo Outcomes(time frame of absolute effects) · children and young people with JIA Methotrexate for juvenile idiopathic arthritis (2024) · Cochrane	no estimate extracted	NR	No studies
Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone Treatment responsea · children and young people with JIA Methotrexate for juvenile idiopathic arthritis (2024) · Cochrane	no estimate extracted	NR	No studies
Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone Function · children and young people with JIA Methotrexate for juvenile idiopathic arthritis (2024) · Cochrane	no estimate extracted	NR	No studies
Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone Pain · children and young people with JIA Methotrexate for juvenile idiopathic arthritis (2024) · Cochrane	no estimate extracted	NR	No studies
Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone Participant global assessment of well‐being · children and young people with JIA Methotrexate for juvenile idiopathic arthritis (2024) · Cochrane	no estimate extracted	NR	No studies
Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone Serious adverse events(12 months) · children and young people with JIA Methotrexate for juvenile idiopathic arthritis (2024) · Cochrane	no estimate extracted	NR	Very low
Methotrexate vs alternative disease‐modifying antirheumatic drugs Outcomes(time frame of absolute effects) · children and young people with JIA Methotrexate for juvenile idiopathic arthritis (2024) · Cochrane	no estimate extracted	NR	No studies
Methotrexate vs alternative disease‐modifying antirheumatic drugs Sustained clinically inactive diseasec · children and young people with JIA Methotrexate for juvenile idiopathic arthritis (2024) · Cochrane	no estimate extracted	NR	No studies
Methotrexate vs alternative disease‐modifying antirheumatic drugs Pain · children and young people with JIA Methotrexate for juvenile idiopathic arthritis (2024) · Cochrane	no estimate extracted	NR	No studies
Methotrexate vs placebo Sustained clinically inactive diseasec · children and young people with JIA Methotrexate for juvenile idiopathic arthritis (2024) · Cochrane	no estimate extracted	NR	No studies
Methotrexate vs placebo Function · children and young people with JIA Methotrexate for juvenile idiopathic arthritis (2024) · Cochrane	no estimate extracted	NR	No studies
Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone Outcomes(time frame of absolute effects) · children and young people with JIA Methotrexate for juvenile idiopathic arthritis (2024) · Cochrane	no estimate extracted	NR	No studies

Reviews 143

Anti‐cytokine targeted therapies for ANCA‐associated vasculitis

Bala, MM, Malecka-Massalska, TJ, et al. · Cochrane Database of Systematic Reviews · 2020

Musculoskeletal

Thinnest evidence

Reviews 143

Anti‐cytokine targeted therapies for ANCA‐associated vasculitis

Shock wave therapy for rotator cuff disease with or without calcification

Tourniquet use for knee replacement surgery

Shoulder replacement surgery for osteoarthritis and rotator cuff tear arthropathy

Tai Chi for rheumatoid arthritis

Tramadol for osteoarthritis

Subacromial decompression surgery for rotator cuff disease

Exercise for improving outcomes after osteoporotic vertebral fracture

Down‐titration and discontinuation strategies of tumour necrosis factor–blocking agents for rheumatoid arthritis in patients with low disease activity

Exercise programmes for ankylosing spondylitis

Surgical interventions for symptomatic mild to moderate knee osteoarthritis

Methotrexate for psoriatic arthritis

Surgery for patellar tendinopathy (jumper’s knee)

Paracetamol versus placebo for knee and hip osteoarthritis

Mixed exercise training for adults with fibromyalgia

Flexibility exercise training for adults with fibromyalgia

Surgery for rotator cuff tears

Exercise for rheumatoid arthritis of the hand

Percutaneous vertebroplasty for osteoporotic vertebral compression fracture

Surgery for trigger finger

Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: a mixed methods review

Corticosteroids for septic arthritis in children

Acupuncture for hip osteoarthritis

Calcium channel blockers for primary and secondary Raynaud's phenomenon

Bisphosphonates for Paget's disease of bone in adults