Cochrane · systematic review · CD000467
Calcium channel blockers for primary and secondary Raynaud's phenomenon
Rirash, F, Tingey, PC, Harding, SE, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 14.3%Very low 0 · 0%Low 3 · 42.9%Moderate 3 · 42.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Calcium channel blockers compared with placebo for treatment of Raynaud's phenomenon
Population: patients with Raynaud's phenomenon
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Frequency of attacks Average number of attacks/week Calcium channel blockers vs placebo | no estimate extracted | 23 studies · 528 participants | Moderate Downgraded: inconsistency |
Duration of attacks Average duration per attack measured in minutes Calcium channel blockers vs placebo | no estimate extracted | 6 studies · 69 participants | Low Downgraded: imprecision, inconsistency |
Severity of attacks Average severity per attack assessed on a 10‐cm visual analogue scale (0 = no symptoms, 10 = maximal severity) Calcium channel blockers vs placebo | no estimate extracted | 18 studies · 415 participants | Moderate Downgraded: inconsistency |
Pain Average pain per attack, measured on a 10‐cm visual analogue scale (0 = no pain, 10 = maximal pain) Calcium channel blockers vs placebo | no estimate extracted | 4 studies · 62 participants | Low Downgraded: imprecision, inconsistency |
Patient global Disability due to Raynaud's assessed on a 10‐cm visual analogue scale (0 = no disability, 10 = maximal disability) Calcium channel blockers vs placebo | no estimate extracted | 2 studies · 92 participants | Moderate Downgraded: imprecision |
Number of withdrawals due to adverse events Number of participants who dropped out of studies owing to adverse treatment effects Calcium channel blockers vs placebo | RR 1.3 [0.51, 3.33] | 2 studies · 63 participants | Low Downgraded: risk of bias, imprecision |
Serious adverse events Number of participants who died or withdrew and were hospitalized as a result of adverse effects of treatment Calcium channel blockers vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |