Cochrane Review Group

Gynaecology and Fertility

194 systematic reviews in Gynaecology and Fertility ask 2,653 questions. 20% have no studies to answer them, 31.1% rest on very low certainty evidence and 13.8% reach moderate or high certainty.

Reviews

194

Questions

2,653

current versions

No studies

20%

Moderate or high

13.8%

No studies 531 · 20%Ungraded 76 · 2.9%Very low 826 · 31.1%Low 855 · 32.2%Moderate 341 · 12.9%High 24 · 0.9%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Search questions in Gynaecology and Fertility

Thinnest evidence

All no studies and very low questions

Question	Effect	Evidence	Status / GRADE
Transvaginal biological graft vs native tissue repair Bladder function · vaginal prolapse Transvaginal mesh or grafts or native tissue repair for vaginal prolapse (2024) · Cochrane	RR 12.64 [1.6, 100.06]	2 studies · 143 participants	Very low
Transvaginal biological graft vs native tissue repair Quality of life · vaginal prolapse Transvaginal mesh or grafts or native tissue repair for vaginal prolapse (2024) · Cochrane	no estimate extracted	3 studies · 112 participants	Very low
Transvaginal permanent mesh vs native tissue repair Recurrent prolapse on examination (any compartment) · vaginal prolapse Transvaginal mesh or grafts or native tissue repair for vaginal prolapse (2024) · Cochrane	RR 0.42 [0.32, 0.55]	25 studies · 3680 participants	Very low
Transvaginal permanent mesh vs native tissue repair Quality of life · vaginal prolapse Transvaginal mesh or grafts or native tissue repair for vaginal prolapse (2024) · Cochrane	no estimate extracted	9 studies · 1365 participants	Very low
Summary of findings table ‐ Metformin vs megestrol Regression of endometrial hyperplasia (with or without atypia) to proliferative, secretory, or atrophic endometrium · endometrial hyperplasia Metformin for endometrial hyperplasia (2024) · Cochrane	OR 4.89 [1.56, 15.32]	2 studies · 83 participants	Very low
Summary of findings table ‐ Metformin + megestrol vs megestrol Progression of endometrial hyperplasia to endometrial cancer · endometrial hyerplasia Metformin for endometrial hyperplasia (2024) · Cochrane	OR 7.96 [0.16, 402.02]	3 studies · 156 participants	Very low
Summary of findings table ‐ Metformin + megestrol vs megestrol Hysterectomy rate · endometrial hyerplasia Metformin for endometrial hyperplasia (2024) · Cochrane	OR 7.39 [0.15, 372.38]	2 studies · 72 participants	Very low
Summary of findings table ‐ Metformin + megestrol vs megestrol Abnormal uterine bleeding ‐ not measured · endometrial hyerplasia Metformin for endometrial hyperplasia (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Metformin + megestrol vs megestrol Health‐related quality of life (HRQoL) ‐ not measured · endometrial hyerplasia Metformin for endometrial hyperplasia (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Metformin + megestrol vs megestrol Adverse effects during treatment · endometrial hyerplasia Metformin for endometrial hyperplasia (2024) · Cochrane	no estimate extracted	1 study · 8 participants	Very low
Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system Regression of endometrial hyperplasia (with or without atypia) to proliferative, secretory, or atrophic endometrium · endometrial hyperplasia Metformin for endometrial hyperplasia (2024) · Cochrane	OR 3.42 [0.13, 88.4]	1 study · 46 participants	Very low
Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system Recurrence of endometrial hyperplasia ‐ not reported · endometrial hyperplasia Metformin for endometrial hyperplasia (2024) · Cochrane	no estimate extracted	NR	No studies

Reviews 194

Growth hormone for in vitro fertilisation (IVF)

Sood, A, Mohiyiddeen, G, et al. · Cochrane Database of Systematic Reviews · 2021

Gynaecology and Fertility

Thinnest evidence

Reviews 194

Growth hormone for in vitro fertilisation (IVF)

Endometrial resection and ablation versus hysterectomy for heavy menstrual bleeding

Surgical or radiological treatment for varicoceles in subfertile men

Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI))

Double versus single intrauterine insemination (IUI) in stimulated cycles for subfertile couples

Levonorgestrel‐releasing intrauterine device (LNG‐IUD) for symptomatic endometriosis following surgery

Monitoring of stimulated cycles in assisted reproduction (IVF and ICSI)

Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility

Uterine distension media for outpatient hysteroscopy

Chinese herbal medicine for subfertile women with polycystic ovarian syndrome

Pentoxifylline for the treatment of endometriosis‐associated pain and infertility

Preconception lifestyle advice for people with infertility

Surgical interventions for the management of chronic pelvic pain in women

Dopamine agonists for preventing ovarian hyperstimulation syndrome

Endometrial injury in women undergoing in vitro fertilisation (IVF)

Selective oestrogen receptor modulators (SERMs) for endometriosis

Fresh versus frozen embryo transfers in assisted reproduction

Oxytocin antagonists for assisted reproduction

Pharmacological and non‐pharmacological strategies for obese women with subfertility

Nifedipine for primary dysmenorrhoea

Barrier agents for adhesion prevention after gynaecological surgery

Laparoscopic ovarian drilling for ovulation induction in women with anovulatory polycystic ovary syndrome

Fluid and pharmacological agents for adhesion prevention after gynaecological surgery

Intra‐uterine insemination for unexplained subfertility

Surgical treatment for tubal disease in women due to undergo in vitro fertilisation