Cochrane · systematic review · CD012650
Pharmacological and non‐pharmacological strategies for obese women with subfertility
Taghavi, SA, van Wely, M, Jahanfar, S, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
25
current version
GRADE rated
19
No studies
6
Included studies
NR
No studies 6 · 24%Ungraded 0 · 0%Very low 15 · 60%Low 4 · 16%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Non‐pharmacological intervention compared to no intervention or placebo for obese women with subfertility
Population: obese women with subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth Non‐pharmacological intervention vs no intervention or placebo | OR 0.85 [0.65, 1.12] | 3 studies · 917 participants | Low Downgraded: inconsistency |
Ongoing pregnancy Non‐pharmacological intervention vs no intervention or placebo | OR 0.81 [0.58, 1.13] | 1 study · 564 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Miscarriage Non‐pharmacological intervention vs no intervention or placebo | OR 1.54 [0.99, 2.39] | 3 studies · 917 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Clinical pregnancy Non‐pharmacological intervention vs no intervention or placebo | OR 1.06 [0.81, 1.4] | 3 studies · 917 participants | Low Downgraded: inconsistency |
Weight changeBMI change (Einarsson 2017) Non‐pharmacological intervention vs no intervention or placebo | no estimate extracted | 1 study · 305 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
BMI change (Sim 2014) Non‐pharmacological intervention vs no intervention or placebo | no estimate extracted | 1 study · 43 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Quality of life/Mental health outcome Non‐pharmacological intervention vs no intervention or placebo | no estimate extracted | NR | No studies |
Non‐pharmacological intervention compared to non‐pharmacological intervention for obese women with subfertility
Population: obese women with subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth Non‐pharmacological intervention vs non‐pharmacological intervention | OR 11 [0.43, 284] | 1 study · 11 participants | Very low Downgraded: risk of bias |
Miscarriage Non‐pharmacological intervention vs non‐pharmacological intervention | no estimate extracted | NR | No studies |
Clinical pregnancy Non‐pharmacological intervention vs non‐pharmacological intervention | OR 11 [0.43, 284] | 1 study · 11 participants | Very low Downgraded: risk of bias |
Weight changeWeight change (kg) Body mass index (BMI) Non‐pharmacological intervention vs non‐pharmacological intervention | no estimate extracted | 1 study · 11 participants | Very low Downgraded: risk of bias |
Quality of life/Mental health outcomeMental health (at 12 weeks) Quality of life (at 12 weeks) Non‐pharmacological intervention vs non‐pharmacological intervention | no estimate extracted | 1 study · 11 participants | Very low Downgraded: risk of bias |
Pharmacological intervention compared to pharmacological intervention for obese women with subfertility
Population: obese women with subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth Pharmacological intervention vs pharmacological intervention | no estimate extracted | NR | No studies |
Adverse events ‐ Metformin plus liraglutide vs metformin Nausea Diarrhoea Headache Pharmacological intervention vs pharmacological intervention | OR 7.22 [0.72, 73] | 1 study · 28 participants | Very low Downgraded: risk of bias |
Clinical pregnancyMetformin plus liraglutide vs metformin Met + CC + L‐carnitine vs Met + CC + placebo Pharmacological intervention vs pharmacological intervention | OR 5.2 [2.59, 10.4] | 1 study · 28 participants | Very low Downgraded: risk of bias |
MiscarriageMet + CC + L‐carnitine vs Met + CC + placebo Pharmacological intervention vs pharmacological intervention | OR 3.58 [0.73, 17.6] | 1 study · 274 participants | Very low Downgraded: risk of bias |
Weight ‐ BMI changeMetformin plus liraglutide vs metformin Met + CC + L‐carnitine vs Met + CC + placebo Weight changeDexfenfluramine vs placebo Weight ‐ body fatMetformin plus liraglutide vs metformin Pharmacological intervention vs pharmacological intervention | no estimate extracted | 1 study · 28 participants | Very low Downgraded: risk of bias |
Quality of life/Mental health outcome Pharmacological intervention vs pharmacological intervention | no estimate extracted | NR | No studies |
Pharmacological intervention compared to no intervention or placebo for obese women with subfertility
Population: obese women with subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth Pharmacological intervention vs no intervention or placebo | OR 1.57 [0.44, 5.57] | 1 study · 65 participants | Very low Downgraded: imprecision |
Ongoing pregnancy Pharmacological intervention vs no intervention or placebo | no estimate extracted | NR | No studies |
Miscarriage Pharmacological intervention vs no intervention or placebo | OR 0.5 [0.04, 5.8] | 1 study · 65 participants | Very low Downgraded: imprecision |
Adverse events (GI) Pharmacological intervention vs no intervention or placebo | OR 0.91 [0.32, 2.57] | 1 study · 65 participants | Very low Downgraded: imprecision |
Clinical pregnancy Pharmacological intervention vs no intervention or placebo | OR 2.67 [0.9, 7.93] | 2 studies · 96 participants | Very low Downgraded: imprecision |
Weight changeBMI WHR Pharmacological intervention vs no intervention or placebo | no estimate extracted | 1 study · 143 participants | Very low Downgraded: imprecision |
Quality of life/Mental health outcome Pharmacological intervention vs no intervention or placebo | no estimate extracted | NR | No studies |