Cochrane Review Group

Gynaecology and Fertility

194 systematic reviews in Gynaecology and Fertility ask 2,653 questions. 20% have no studies to answer them, 31.1% rest on very low certainty evidence and 13.8% reach moderate or high certainty.

Reviews

194

Questions

2,653

current versions

No studies

20%

Moderate or high

13.8%

No studies 531 · 20%Ungraded 76 · 2.9%Very low 826 · 31.1%Low 855 · 32.2%Moderate 341 · 12.9%High 24 · 0.9%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Search questions in Gynaecology and Fertility

Thinnest evidence

All no studies and very low questions

Question	Effect	Evidence	Status / GRADE
Transvaginal biological graft vs native tissue repair Bladder function · vaginal prolapse Transvaginal mesh or grafts or native tissue repair for vaginal prolapse (2024) · Cochrane	RR 12.64 [1.6, 100.06]	2 studies · 143 participants	Very low
Transvaginal biological graft vs native tissue repair Quality of life · vaginal prolapse Transvaginal mesh or grafts or native tissue repair for vaginal prolapse (2024) · Cochrane	no estimate extracted	3 studies · 112 participants	Very low
Transvaginal permanent mesh vs native tissue repair Recurrent prolapse on examination (any compartment) · vaginal prolapse Transvaginal mesh or grafts or native tissue repair for vaginal prolapse (2024) · Cochrane	RR 0.42 [0.32, 0.55]	25 studies · 3680 participants	Very low
Transvaginal permanent mesh vs native tissue repair Quality of life · vaginal prolapse Transvaginal mesh or grafts or native tissue repair for vaginal prolapse (2024) · Cochrane	no estimate extracted	9 studies · 1365 participants	Very low
Summary of findings table ‐ Metformin vs megestrol Regression of endometrial hyperplasia (with or without atypia) to proliferative, secretory, or atrophic endometrium · endometrial hyperplasia Metformin for endometrial hyperplasia (2024) · Cochrane	OR 4.89 [1.56, 15.32]	2 studies · 83 participants	Very low
Summary of findings table ‐ Metformin + megestrol vs megestrol Progression of endometrial hyperplasia to endometrial cancer · endometrial hyerplasia Metformin for endometrial hyperplasia (2024) · Cochrane	OR 7.96 [0.16, 402.02]	3 studies · 156 participants	Very low
Summary of findings table ‐ Metformin + megestrol vs megestrol Hysterectomy rate · endometrial hyerplasia Metformin for endometrial hyperplasia (2024) · Cochrane	OR 7.39 [0.15, 372.38]	2 studies · 72 participants	Very low
Summary of findings table ‐ Metformin + megestrol vs megestrol Abnormal uterine bleeding ‐ not measured · endometrial hyerplasia Metformin for endometrial hyperplasia (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Metformin + megestrol vs megestrol Health‐related quality of life (HRQoL) ‐ not measured · endometrial hyerplasia Metformin for endometrial hyperplasia (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Metformin + megestrol vs megestrol Adverse effects during treatment · endometrial hyerplasia Metformin for endometrial hyperplasia (2024) · Cochrane	no estimate extracted	1 study · 8 participants	Very low
Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system Regression of endometrial hyperplasia (with or without atypia) to proliferative, secretory, or atrophic endometrium · endometrial hyperplasia Metformin for endometrial hyperplasia (2024) · Cochrane	OR 3.42 [0.13, 88.4]	1 study · 46 participants	Very low
Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system Recurrence of endometrial hyperplasia ‐ not reported · endometrial hyperplasia Metformin for endometrial hyperplasia (2024) · Cochrane	no estimate extracted	NR	No studies

Reviews 194

Transvaginal mesh or grafts or native tissue repair for vaginal prolapse

Yeung, E, Baessler, K, et al. · Cochrane Database of Systematic Reviews · 2024

Gynaecology and Fertility

Thinnest evidence

Reviews 194

Transvaginal mesh or grafts or native tissue repair for vaginal prolapse

Metformin for endometrial hyperplasia

Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro fertilisation plus intracytoplasmic sperm injection (IVF/ICSI)

Autologous platelet‐rich plasma for assisted reproduction

Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with normal total sperm count and motility

Combined oral contraceptive pill for primary dysmenorrhoea

In vitro fertilisation for unexplained subfertility

Surgical approach to hysterectomy for benign gynaecological disease

Oral contraceptives containing drospirenone for premenstrual syndrome

Statins for women with polycystic ovary syndrome not actively trying to conceive

Antibiotics prior to or at the time of embryo transfer in ART

Hormone therapy for sexual function in perimenopausal and postmenopausal women

Timed intercourse for couples trying to conceive

Surgery for women with apical vaginal prolapse

Progestogens for prevention of luteinising hormone (LH) surge in women undergoing controlled ovarian hyperstimulation as part of an assisted reproductive technology (ART) cycle

Gonadotropin‐releasing hormone analogues for endometriosis

Cleavage‐stage versus blastocyst‐stage embryo transfer in assisted reproductive technology

Follicular flushing during oocyte retrieval in assisted reproductive techniques

Peri‐implantation glucocorticoid administration for assisted reproductive technology cycles

Antioxidants for male subfertility

Hormone therapy for uterine and endometrial development in women with premature ovarian insufficiency

Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome

Endometrial injury for pregnancy following sexual intercourse or intrauterine insemination

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse

Day 5 versus day 3 embryo biopsy for preimplantation genetic testing for monogenic/single gene defects