Cochrane · systematic review · CD003357
In vitro fertilisation for unexplained subfertility
Sunkara, SK, Kamath, MS, Pandian, Z, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
11
No studies
4
Included studies
NR
No studies 4 · 26.7%Ungraded 0 · 0%Very low 7 · 46.7%Low 4 · 26.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 3 versionsIVF versus expectant management for unexplained subfertility
Population: women with unexplained subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth per woman randomised IVF vs expectant management | OR 22 [2.56, 189.37] | 1 study · 51 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Clinical pregnancy rate per woman randomised IVF vs expectant management | OR 3.24 [1.07, 9.8] | 2 studies · 86 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Multiple pregnancy rate per woman randomised IVF vs expectant management | no estimate extracted | NR | No studies |
OHSS rate per woman randomised IVF vs expectant management | no estimate extracted | NR | No studies |
Miscarriage rate per woman randomised IVF vs expectant management | no estimate extracted | NR | No studies |
IVF versus unstimulated IUI for unexplained subfertility
Population: women with unexplained subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per woman randomised IVF vs unstimulated IUI | OR 2.47 [1.19, 5.12] | 2 studies · 156 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Clinical pregnancy rate per woman randomised IVF vs unstimulated IUI | OR 4.83 [0.94, 24.95] | 1 study · 43 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Multiple pregnancy rate per woman randomised IVF vs unstimulated IUI | OR 1.03 [0.04, 27.29] | 1 study · 43 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
OHSS rate per woman randomised IVF vs unstimulated IUI | no estimate extracted | NR | No studies |
Miscarriage rate per woman randomised IVF vs unstimulated IUI | OR 1.72 [0.14, 21.25] | 1 study · 43 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
IVF versus IUI + ovarian stimulation with gonadotropins or CC for unexplained subfertility
Population: women with unexplained subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per woman randomised IVF vs IUI + ovarian stimulation with gonadotropins or CC | OR 1.19 [0.87, 1.61] | 3 studies · 731 participants | Low Downgraded: risk of bias, imprecision |
Clinical pregnancy rate per woman randomised IVF vs IUI + ovarian stimulation with gonadotropins or CC | OR 1.17 [0.85, 1.59] | 3 studies · 731 participants | Low Downgraded: risk of bias, imprecision |
Multiple pregnancy rate per woman randomised IVF vs IUI + ovarian stimulation with gonadotropins or CC | OR 0.82 [0.38, 1.77] | 3 studies · 731 participants | Low Downgraded: risk of bias, imprecision |
OHSS rate per woman randomised IVF vs IUI + ovarian stimulation with gonadotropins or CC | OR 6.86 [0.35, 134.59] | 1 study · 207 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Miscarriage rate per woman randomised IVF vs IUI + ovarian stimulation with gonadotropins or CC | OR 0.31 [0.03, 3.04] | 1 study · 207 participants | Very low Downgraded: risk of bias, imprecision, indirectness |