Cochrane · systematic review · CD013233
Day 5 versus day 3 embryo biopsy for preimplantation genetic testing for monogenic/single gene defects
Vlajkovic, T, Grigore, M, van Eekelen, R, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 6 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Day 5 compared to day 3 embryo biopsy for preimplantation genetic testing for monogenic/single gene defects
Population: people having preimplantation genetic testing for monogenic/single gene defects
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth Day 5 vs day 3 embryo biopsy | OR 1.5 [0.26, 8.82] | 1 study · 20 participants | Very low Downgraded: risk of bias, imprecision |
Miscarriage Day 5 vs day 3 embryo biopsy | OR 1 [0.05, 18.57] | 1 study · 20 participants | Very low Downgraded: risk of bias, imprecision |
Viable intrauterine pregnancy Day 5 vs day 3 embryo biopsy | OR 2.25 [0.38, 13.47] | 1 study · 20 participants | Very low Downgraded: risk of bias, imprecision |
Ectopic pregnancy Day 5 vs day 3 embryo biopsy | OR 0.16 [0.01, 3.85] | 1 study · 20 participants | Very low Downgraded: risk of bias, imprecision |
Stillbirth Day 5 vs day 3 embryo biopsy | no estimate extracted | 1 study · 20 participants | Very low Downgraded: risk of bias, imprecision |
Termination of pregnancy Day 5 vs day 3 embryo biopsy | OR 3.32 [0.12, 91.6] | 1 study · 20 participants | Very low Downgraded: risk of bias, imprecision |