Cochrane · systematic review · CD013875
Autologous platelet‐rich plasma for assisted reproduction
Vaidakis, D, Papapanou, M, Siristatidis, CS · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
18
current version
GRADE rated
15
No studies
3
Included studies
NR
No studies 3 · 16.7%Ungraded 0 · 0%Very low 14 · 77.8%Low 1 · 5.6%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Intrauterine injection of autologous platelet‐rich plasma versus no intervention in women undergoing assisted reproduction (studies judged at low risk of bias)
Population: women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth (or ongoing pregnancy) Intrauterine injection of autologous platelet‐rich plasma vs no intervention | OR 1.1 [0.38, 3.14] | 1 study · 94 participants | Very low Downgraded: imprecision, indirectness |
Miscarriage Intrauterine injection of autologous platelet‐rich plasma vs no intervention | OR 0.96 [0.13, 7.09] | 1 study · 94 participants | Very low Downgraded: imprecision, indirectness |
Clinical pregnancy Intrauterine injection of autologous platelet‐rich plasma vs no intervention | OR 1.55 [0.64, 3.76] | 1 study · 94 participants | Very low Downgraded: imprecision, indirectness |
Adverse events: ectopic pregnancy Intrauterine injection of autologous platelet‐rich plasma vs no intervention | OR 2.94 [0.12, 73.95] | 1 study · 94 participants | Very low Downgraded: imprecision, indirectness |
Intrauterine infusion/injection of autologous platelet‐rich plasma compared to no intervention or placebo in women undergoing assisted reproduction (all studies)
Population: women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth (or ongoing pregnancy) Intrauterine infusion/injection of autologous platelet‐rich plasma vs no intervention or placebo | OR 2.38 [1.16, 4.86] | 6 studies · 564 participants | Very low Downgraded: risk of bias, inconsistency, indirectness |
Miscarriage Intrauterine infusion/injection of autologous platelet‐rich plasma vs no intervention or placebo | OR 1.54 [0.59, 4.01] | 5 studies · 504 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Clinical pregnancy Intrauterine infusion/injection of autologous platelet‐rich plasma vs no intervention or placebo | OR 2.22 [1.5, 3.27] | 9 studies · 824 participants | Very low Downgraded: risk of bias, indirectness |
Adverse events: multiple pregnancy Intrauterine infusion/injection of autologous platelet‐rich plasma vs no intervention or placebo | OR 2.68 [0.81, 8.88] | 2 studies · 240 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Adverse events: ectopic pregnancy Intrauterine infusion/injection of autologous platelet‐rich plasma vs no intervention or placebo | OR 2.94 [0.12, 73.95] | 1 study · 94 participants | Very low Downgraded: imprecision, indirectness |
Adverse events: preterm delivery Intrauterine infusion/injection of autologous platelet‐rich plasma vs no intervention or placebo | OR 8.02 [1.72, 37.33] | 1 study · 120 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Intrauterine infusion of autologous platelet‐rich plasma compared to intrauterine infusion of granulocyte colony‐stimulating factor in women undergoing assisted reproduction (all studies)
Population: women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth (or ongoing pregnancy Intrauterine infusion of autologous platelet‐rich plasma vs intrauterine infusion of granulocyte colony‐stimulating factor | OR 0.88 [0.43, 1.81] | 1 study · 132 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Miscarriage Intrauterine infusion of autologous platelet‐rich plasma vs intrauterine infusion of granulocyte colony‐stimulating factor | OR 1.94 [0.63, 5.96] | 1 study · 132 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Clinical pregnancy Intrauterine infusion of autologous platelet‐rich plasma vs intrauterine infusion of granulocyte colony‐stimulating factor | OR 1.24 [0.66, 2.35] | 2 studies · 172 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Adverse events Intrauterine infusion of autologous platelet‐rich plasma vs intrauterine infusion of granulocyte colony‐stimulating factor | no estimate extracted | NR | No studies |
Intraovarian injection of autologous platelet‐rich plasma compared to no intervention in women undergoing assisted reproduction (all studies)
Population: women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Ongoing pregnancy Intraovarian injection of autologous platelet‐rich plasma vs no intervention | OR 1.09 [0.33, 3.63] | 1 study · 73 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Miscarriage Intraovarian injection of autologous platelet‐rich plasma vs no intervention | no estimate extracted | NR | No studies |
Clinical pregnancy Intraovarian injection of autologous platelet‐rich plasma vs no intervention | OR 0.9 [0.31, 2.6] | 1 study · 73 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Adverse events Intraovarian injection of autologous platelet‐rich plasma vs no intervention | no estimate extracted | NR | No studies |