Cochrane · systematic review · CD006586
Oral contraceptives containing drospirenone for premenstrual syndrome
Ma, S, Song, SJ · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 7 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Drospirenone plus ethinylestradiol compared to placebo for premenstrual syndrome – primary outcomes
Population: women with premenstrual syndrome (most met DSM‐V criteria for premenstrual dysphoric disorder (PMDD))
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mean daily rating of problem severity (lower score is better) Drospirenone plus ethinylestradiol vs placebo | no estimate extracted | 2 studies · 513 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Mean change in daily rating of functional impairment: reduction of productivity (lower score is better) Drospirenone plus ethinylestradiol vs placebo | no estimate extracted | 2 studies · 432 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Mean change in daily rating of functional impairment: social activities (lower score is better) Drospirenone plus ethinylestradiol vs placebo | no estimate extracted | 2 studies · 432 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Mean change in daily rating of functional impairment: relationship interference (lower score is better) Drospirenone plus ethinylestradiol vs placebo | no estimate extracted | 2 studies · 432 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Changes in Premenstrual Tension Scale scores (observer‐rated; lower score is better) Drospirenone plus ethinylestradiol vs placebo | no estimate extracted | 1 study · 387 participants | Low Downgraded: risk of bias, imprecision |
Changes in Premenstrual Tension Scale scores (self‐rated; lower score is better) Drospirenone plus ethinylestradiol vs placebo | no estimate extracted | 2 studies · 438 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Withdrawal due to adverse events Drospirenone plus ethinylestradiol vs placebo | OR 3.41 [2.01, 5.78] | 4 studies · 776 participants | Low Downgraded: risk of bias, imprecision |